The level of haemoglobin in anaemic cancer patients correlates positively with quality of life.

2.50
Hdl Handle:
http://hdl.handle.net/10541/80238
Title:
The level of haemoglobin in anaemic cancer patients correlates positively with quality of life.
Authors:
Lind, Michael J; Vernon, C; Cruickshank, D; Wilkinson, Peter M; Littlewood, Timothy; Stuart, N; Jenkinson, C; Grey-Amante, P; Doll, H; Wild, D
Abstract:
The aim of this study was to assess the relationship between haemoglobin level and quality-of-life in anaemic cancer patients. Patients, diagnosed with one of four cancers, were recruited if their haemoglobin level was <12 g dl(-1) (female) or <13 g dl(-1) (male). The condition-specific Functional Assessment of Cancer Therapy-Anaemia and the generic SF-36 were used to assess quality-of-life. Thirty-six per cent of the 179 recruited patients had breast cancer, 28% ovarian cancer, 25% lung cancer, and 11% multiple myeloma. Their mean (s.d.) haemoglobin level was 10.66 (1.04) g dl(-1). Partial correlations controlling for the potentially confounding effects of age, gender, and time since diagnosis found significant positive relationships between haemoglobin and all domains of the Functional Assessment of Cancer Therapy-Anaemia, and with all but two of the SF-36 domains. On linear regression controlling for the same factors, each unit haemoglobin rise equalled an average 8.19 Functional Assessment of Cancer Therapy-Anaemia, and an average 6.88 Functional Assessment of Cancer Therapy-Fatigue, increase. Haemoglobin accounted for a similar amount of variability (8%) in SF-36 scores. In conclusion, quality-of-life has been found to be significantly positively related to haemoglobin level in anaemic cancer patients. This suggests that normalisation of haemoglobin in cancer patients is likely to increase their quality-of-life. The greater sensitivity of the condition-specific Functional Assessment of Cancer Therapy-Anaemia compared with the generic SF-36 suggests that the Functional Assessment of Cancer Therapy-Anaemia can be used alone to assess quality-of life in this patient group.
Affiliation:
Princess Royal Hospital, Salthouse Road, Hull HU8 9HE, UK.
Citation:
The level of haemoglobin in anaemic cancer patients correlates positively with quality of life. 2002, 86 (8):1243-9 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
22-Apr-2002
URI:
http://hdl.handle.net/10541/80238
DOI:
10.1038/sj.bjc.6600247
PubMed ID:
11953880
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLind, Michael J-
dc.contributor.authorVernon, C-
dc.contributor.authorCruickshank, D-
dc.contributor.authorWilkinson, Peter M-
dc.contributor.authorLittlewood, Timothy-
dc.contributor.authorStuart, N-
dc.contributor.authorJenkinson, C-
dc.contributor.authorGrey-Amante, P-
dc.contributor.authorDoll, H-
dc.contributor.authorWild, D-
dc.date.accessioned2009-09-08T10:21:02Z-
dc.date.available2009-09-08T10:21:02Z-
dc.date.issued2002-04-22-
dc.identifier.citationThe level of haemoglobin in anaemic cancer patients correlates positively with quality of life. 2002, 86 (8):1243-9 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid11953880-
dc.identifier.doi10.1038/sj.bjc.6600247-
dc.identifier.urihttp://hdl.handle.net/10541/80238-
dc.description.abstractThe aim of this study was to assess the relationship between haemoglobin level and quality-of-life in anaemic cancer patients. Patients, diagnosed with one of four cancers, were recruited if their haemoglobin level was <12 g dl(-1) (female) or <13 g dl(-1) (male). The condition-specific Functional Assessment of Cancer Therapy-Anaemia and the generic SF-36 were used to assess quality-of-life. Thirty-six per cent of the 179 recruited patients had breast cancer, 28% ovarian cancer, 25% lung cancer, and 11% multiple myeloma. Their mean (s.d.) haemoglobin level was 10.66 (1.04) g dl(-1). Partial correlations controlling for the potentially confounding effects of age, gender, and time since diagnosis found significant positive relationships between haemoglobin and all domains of the Functional Assessment of Cancer Therapy-Anaemia, and with all but two of the SF-36 domains. On linear regression controlling for the same factors, each unit haemoglobin rise equalled an average 8.19 Functional Assessment of Cancer Therapy-Anaemia, and an average 6.88 Functional Assessment of Cancer Therapy-Fatigue, increase. Haemoglobin accounted for a similar amount of variability (8%) in SF-36 scores. In conclusion, quality-of-life has been found to be significantly positively related to haemoglobin level in anaemic cancer patients. This suggests that normalisation of haemoglobin in cancer patients is likely to increase their quality-of-life. The greater sensitivity of the condition-specific Functional Assessment of Cancer Therapy-Anaemia compared with the generic SF-36 suggests that the Functional Assessment of Cancer Therapy-Anaemia can be used alone to assess quality-of life in this patient group.en
dc.language.isoenen
dc.subjectAnaemiaen
dc.subjectHaemoglobinsen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAnemia-
dc.subject.meshFemale-
dc.subject.meshGreat Britain-
dc.subject.meshHemoglobins-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshQuality of Life-
dc.subject.meshQuestionnaires-
dc.subject.meshRegression Analysis-
dc.titleThe level of haemoglobin in anaemic cancer patients correlates positively with quality of life.en
dc.typeArticleen
dc.contributor.departmentPrincess Royal Hospital, Salthouse Road, Hull HU8 9HE, UK.en
dc.identifier.journalBritish Journal of Canceren

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