Anaplastic plasmacytoma with malignant pleural effusion lacking evidence of monoclonal gammopathy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/80216
Title:
Anaplastic plasmacytoma with malignant pleural effusion lacking evidence of monoclonal gammopathy.
Authors:
Aoki, Takuya; Okita, Hajime; Kayano, Hidekazu; Orikasa, Hideki; Watanabe, Kentaro; Eyden, Brian P; Yamazaki, Kazuto
Abstract:
A case of plasmacytoma of the pleural cavity is reported with massive malignant pleural effusion, which, most unusually, lacked monoclonal gammopathy, thereby making it difficult to distinguish from lymphoma. The pleural tumor and pleural effusion contained large mononuclear lymphoma-like cells with distinct nucleoli. Immunohistochemistry revealed neither lymphoma markers nor clonal cytoplasmic nor cell surface immunoglobulins. Tumor cells were stained with vimentin and the plasma cell markers, VS38c, CD138 (syndecan-1), and MUM1 antibodies. Bone marrow contained small amounts of tumor consisting of similar cells. Electron microscopy showed well developed rough endoplasmic reticulum and peripherally positioned nuclei with euchromatin. Flow cytometry of bone marrow revealed a minimal involvement of CD38-positive cells. Chromosomal analysis of marrow cells revealed a complex abnormal karyotype. A polymerase chain reaction demonstrated clonal re-arrangement of the immunoglobulin heavy-chain gene. The overall results indicate a clonal expansion of tumor cells with primitive plasma cell differentiation with the highly unusual feature of absent monotypic immunoglobulin. The study illustrates the need for a comprehensive array of techniques to distinguish such rare non-synthesizing and non-secretory plasmacytomas from lymphoma.
Affiliation:
Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan.
Citation:
Anaplastic plasmacytoma with malignant pleural effusion lacking evidence of monoclonal gammopathy. 2002, 441 (2):154-8 Virchows Arch.
Journal:
Virchows Archiv
Issue Date:
Aug-2002
URI:
http://hdl.handle.net/10541/80216
DOI:
10.1007/s00428-001-0579-4
PubMed ID:
12189505
Type:
Article
Language:
en
ISSN:
0945-6317
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorAoki, Takuya-
dc.contributor.authorOkita, Hajime-
dc.contributor.authorKayano, Hidekazu-
dc.contributor.authorOrikasa, Hideki-
dc.contributor.authorWatanabe, Kentaro-
dc.contributor.authorEyden, Brian P-
dc.contributor.authorYamazaki, Kazuto-
dc.date.accessioned2009-09-08T09:01:18Z-
dc.date.available2009-09-08T09:01:18Z-
dc.date.issued2002-08-
dc.identifier.citationAnaplastic plasmacytoma with malignant pleural effusion lacking evidence of monoclonal gammopathy. 2002, 441 (2):154-8 Virchows Arch.en
dc.identifier.issn0945-6317-
dc.identifier.pmid12189505-
dc.identifier.doi10.1007/s00428-001-0579-4-
dc.identifier.urihttp://hdl.handle.net/10541/80216-
dc.description.abstractA case of plasmacytoma of the pleural cavity is reported with massive malignant pleural effusion, which, most unusually, lacked monoclonal gammopathy, thereby making it difficult to distinguish from lymphoma. The pleural tumor and pleural effusion contained large mononuclear lymphoma-like cells with distinct nucleoli. Immunohistochemistry revealed neither lymphoma markers nor clonal cytoplasmic nor cell surface immunoglobulins. Tumor cells were stained with vimentin and the plasma cell markers, VS38c, CD138 (syndecan-1), and MUM1 antibodies. Bone marrow contained small amounts of tumor consisting of similar cells. Electron microscopy showed well developed rough endoplasmic reticulum and peripherally positioned nuclei with euchromatin. Flow cytometry of bone marrow revealed a minimal involvement of CD38-positive cells. Chromosomal analysis of marrow cells revealed a complex abnormal karyotype. A polymerase chain reaction demonstrated clonal re-arrangement of the immunoglobulin heavy-chain gene. The overall results indicate a clonal expansion of tumor cells with primitive plasma cell differentiation with the highly unusual feature of absent monotypic immunoglobulin. The study illustrates the need for a comprehensive array of techniques to distinguish such rare non-synthesizing and non-secretory plasmacytomas from lymphoma.en
dc.language.isoenen
dc.subjectCancer DNAen
dc.subjectCancer Proteinsen
dc.subjectPleural Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBase Sequence-
dc.subject.meshBone Marrow Cells-
dc.subject.meshCell Nucleus-
dc.subject.meshChromosome Aberrations-
dc.subject.meshClone Cells-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLymphoma-
dc.subject.meshMale-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshOrganelles-
dc.subject.meshParaproteinemias-
dc.subject.meshPlasmacytoma-
dc.subject.meshPleural Cavity-
dc.subject.meshPleural Effusion, Malignant-
dc.subject.meshPleural Neoplasms-
dc.subject.meshPolymerase Chain Reaction-
dc.subject.meshTumor Markers, Biological-
dc.titleAnaplastic plasmacytoma with malignant pleural effusion lacking evidence of monoclonal gammopathy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan.en
dc.identifier.journalVirchows Archiven

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