Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth.

2.50
Hdl Handle:
http://hdl.handle.net/10541/80136
Title:
Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth.
Authors:
Robson, Helen; Siebler, Thomas; Shalet, Stephen M; Williams, Graham R
Abstract:
Linear growth occurs during development and the childhood years until epiphyseal fusion occurs. This process results from endochondral ossification in the growth plates of long bones and is regulated by systemic hormones and paracrine or autocrine factors. The major regulators of developmental and childhood growth are GH, IGF-I, glucocorticoids, and thyroid hormone. Sex steroids are responsible for the pubertal growth spurt and epiphyseal fusion. This review will consider interactions between GH, IGF-I, glucocorticoids, and thyroid hormone during linear growth. It is well known from physiologic and clinical studies that these hormones interact at the level of the hypothalamus and pituitary. Interacting effects on peripheral tissues such as liver are also well understood, but we concentrate here on the epiphyseal growth plate as an important and newly appreciated target organ for convergent hormone action.
Affiliation:
Department of Clinical Research, Christie Hospital National Health Service Trust, Manchester, UK.
Citation:
Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth. 2002, 52 (2):137-47 Pediatr. Res.
Journal:
Pediatric Research
Issue Date:
Aug-2002
URI:
http://hdl.handle.net/10541/80136
PubMed ID:
12149488
Type:
Article
Language:
en
ISSN:
0031-3998
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRobson, Helen-
dc.contributor.authorSiebler, Thomas-
dc.contributor.authorShalet, Stephen M-
dc.contributor.authorWilliams, Graham R-
dc.date.accessioned2009-09-07T15:09:14Z-
dc.date.available2009-09-07T15:09:14Z-
dc.date.issued2002-08-
dc.identifier.citationInteractions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth. 2002, 52 (2):137-47 Pediatr. Res.en
dc.identifier.issn0031-3998-
dc.identifier.pmid12149488-
dc.identifier.urihttp://hdl.handle.net/10541/80136-
dc.description.abstractLinear growth occurs during development and the childhood years until epiphyseal fusion occurs. This process results from endochondral ossification in the growth plates of long bones and is regulated by systemic hormones and paracrine or autocrine factors. The major regulators of developmental and childhood growth are GH, IGF-I, glucocorticoids, and thyroid hormone. Sex steroids are responsible for the pubertal growth spurt and epiphyseal fusion. This review will consider interactions between GH, IGF-I, glucocorticoids, and thyroid hormone during linear growth. It is well known from physiologic and clinical studies that these hormones interact at the level of the hypothalamus and pituitary. Interacting effects on peripheral tissues such as liver are also well understood, but we concentrate here on the epiphyseal growth plate as an important and newly appreciated target organ for convergent hormone action.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshBone Development-
dc.subject.meshGlucocorticoids-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshThyroid Hormones-
dc.titleInteractions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Research, Christie Hospital National Health Service Trust, Manchester, UK.en
dc.identifier.journalPediatric Researchen
All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.