Recurrent or residual pelvic bowel cancer: accuracy of MRI local extent before salvage surgery.

2.50
Hdl Handle:
http://hdl.handle.net/10541/80133
Title:
Recurrent or residual pelvic bowel cancer: accuracy of MRI local extent before salvage surgery.
Authors:
Robinson, Philip; Carrington, Bernadette M; Swindell, Ric; Shanks, Jonathan H; O'Dwyer, Sarah T
Abstract:
PURPOSE: To determine pre-operative MRI accuracy in assessing local disease extent in recurrent/residual pelvic bowel cancer by comparing MRI assessment and staging examination under anaesthesia (EUA), with laparotomy/histopathological findings. MATERIALS AND METHODS: Twenty-seven consecutive patients with recurrent (n = 21) or residual (n = 6) pelvic bowel cancer (13 of the rectum, eleven of the anus and three of the colon) underwent EUA and pelvic MRI (1T) using a phased array pelvic coil. Retrospective analysis of eight specific anatomical regions for tumour involvement on MRI was performed. Findings at EUA and biopsy were recorded. The MRI and EUA findings were correlated with findings at surgery and histopathology. Statistical comparison between MRI and EUA results was performed using the chi-squared test. RESULTS: Overall MRI accuracy in determining tumour invasion for all sites assessed was 452/499 (91%), sensitivity was 95/109 (87%), specificity was 357/390 (92%), positive predictive value (PPV) was 95/128 (74%) and negative predictive value (NPV) was 357/371 (96%). PPV and NPV for specific areas were 21/38 (55%) and 134/136 (99%) for genitourinary tract, 4/6 (67%) and 61/65 (94%) for pelvic side wall, 21/26 (81%) and 40/41 (98%) for pelvic floor, 1/6 (17%) and 40/43 (93%) for the posterior pelvis pre-sacrum/sacrum. For those anatomical sites evaluated by both EUA and MRI, MRI was superior to EUA, with an accuracy of 89% vs 73% (P < 0.05). CONCLUSION: MRI is an accurate technique for assessing disease extent in recurrent/residual pelvic bowel cancer.
Affiliation:
Departments of Diagnostic Radiology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Recurrent or residual pelvic bowel cancer: accuracy of MRI local extent before salvage surgery. 2002, 57 (6):514-22 Clin Radiol
Journal:
Clinical Radiology
Issue Date:
Jun-2002
URI:
http://hdl.handle.net/10541/80133
DOI:
10.1053/crad.2002.0933
PubMed ID:
12069470
Type:
Article
Language:
en
ISSN:
0009-9260
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRobinson, Philip-
dc.contributor.authorCarrington, Bernadette M-
dc.contributor.authorSwindell, Ric-
dc.contributor.authorShanks, Jonathan H-
dc.contributor.authorO'Dwyer, Sarah T-
dc.date.accessioned2009-09-07T15:01:25Z-
dc.date.available2009-09-07T15:01:25Z-
dc.date.issued2002-06-
dc.identifier.citationRecurrent or residual pelvic bowel cancer: accuracy of MRI local extent before salvage surgery. 2002, 57 (6):514-22 Clin Radiolen
dc.identifier.issn0009-9260-
dc.identifier.pmid12069470-
dc.identifier.doi10.1053/crad.2002.0933-
dc.identifier.urihttp://hdl.handle.net/10541/80133-
dc.description.abstractPURPOSE: To determine pre-operative MRI accuracy in assessing local disease extent in recurrent/residual pelvic bowel cancer by comparing MRI assessment and staging examination under anaesthesia (EUA), with laparotomy/histopathological findings. MATERIALS AND METHODS: Twenty-seven consecutive patients with recurrent (n = 21) or residual (n = 6) pelvic bowel cancer (13 of the rectum, eleven of the anus and three of the colon) underwent EUA and pelvic MRI (1T) using a phased array pelvic coil. Retrospective analysis of eight specific anatomical regions for tumour involvement on MRI was performed. Findings at EUA and biopsy were recorded. The MRI and EUA findings were correlated with findings at surgery and histopathology. Statistical comparison between MRI and EUA results was performed using the chi-squared test. RESULTS: Overall MRI accuracy in determining tumour invasion for all sites assessed was 452/499 (91%), sensitivity was 95/109 (87%), specificity was 357/390 (92%), positive predictive value (PPV) was 95/128 (74%) and negative predictive value (NPV) was 357/371 (96%). PPV and NPV for specific areas were 21/38 (55%) and 134/136 (99%) for genitourinary tract, 4/6 (67%) and 61/65 (94%) for pelvic side wall, 21/26 (81%) and 40/41 (98%) for pelvic floor, 1/6 (17%) and 40/43 (93%) for the posterior pelvis pre-sacrum/sacrum. For those anatomical sites evaluated by both EUA and MRI, MRI was superior to EUA, with an accuracy of 89% vs 73% (P < 0.05). CONCLUSION: MRI is an accurate technique for assessing disease extent in recurrent/residual pelvic bowel cancer.en
dc.language.isoenen
dc.subjectAnus Canceren
dc.subjectCancer Invasivenessen
dc.subjectCancer Recurrenceen
dc.subjectCancer Stagingen
dc.subjectResidual Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAnus Neoplasms-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshFemale-
dc.subject.meshGenitalia, Female-
dc.subject.meshGenitalia, Male-
dc.subject.meshHumans-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshNeoplasm Staging-
dc.subject.meshNeoplasm, Residual-
dc.subject.meshPelvis-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshRetrospective Studies-
dc.subject.meshSalvage Therapy-
dc.subject.meshSensitivity and Specificity-
dc.titleRecurrent or residual pelvic bowel cancer: accuracy of MRI local extent before salvage surgery.en
dc.typeArticleen
dc.contributor.departmentDepartments of Diagnostic Radiology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalClinical Radiologyen

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