Cerebral metastasis and other cerebral events in women with ovarian cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/79975
Title:
Cerebral metastasis and other cerebral events in women with ovarian cancer.
Authors:
Sanderson, A; Bonington, Suzanne C; Carrington, Bernadette M; Alison, D L; Spencer, J A
Abstract:
AIM: To determine the incidence, imaging findings and prognostic significance of cerebral metastases and other cerebral events in women with ovarian cancer. METHOD: A 5-year retrospective review of all women with ovarian cancer who had cranial imaging was undertaken at two major gynaecological oncology centers. RESULTS: Of 1222 women under clinical review, 78 underwent cranial imaging and 13 (1.1%) had cerebral metastasis. Computed tomography (CT) was diagnostic of parenchymal disease in 12 and magnetic resonance imaging (MRI) showed leptomeningeal disease in two. The women were aged between 23 and 73 years and all had stage III or IV disease at presentation. Cerebral metastasis occurred at 6-60 months from initial diagnosis, with death occurring predominantly within 12 months, but with five survivors at 4-45 months. Of the remaining 65 women, 10 had cerebrovascular disease and three had unrelated lesions. CONCLUSION: Cerebral metastasis remains a rare event in women with ovarian cancer but may be an isolated late event associated with survival beyond a year after neurosurgery and chemotherapy. CT should be the first investigation as the incidence of cerebrovascular disease is similar to that of metastatic disease.
Affiliation:
Department of Clinical Radiology and Medical Oncology, St James's University Hospital, Leeds, UK.
Citation:
Cerebral metastasis and other cerebral events in women with ovarian cancer. 2002, 57 (9):815-9 Clin Radiol
Journal:
Clinical Radiology
Issue Date:
Sep-2002
URI:
http://hdl.handle.net/10541/79975
DOI:
10.1053/crad.2001.0965
PubMed ID:
12384107
Type:
Article
Language:
en
ISSN:
0009-9260
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSanderson, A-
dc.contributor.authorBonington, Suzanne C-
dc.contributor.authorCarrington, Bernadette M-
dc.contributor.authorAlison, D L-
dc.contributor.authorSpencer, J A-
dc.date.accessioned2009-09-07T10:24:46Z-
dc.date.available2009-09-07T10:24:46Z-
dc.date.issued2002-09-
dc.identifier.citationCerebral metastasis and other cerebral events in women with ovarian cancer. 2002, 57 (9):815-9 Clin Radiolen
dc.identifier.issn0009-9260-
dc.identifier.pmid12384107-
dc.identifier.doi10.1053/crad.2001.0965-
dc.identifier.urihttp://hdl.handle.net/10541/79975-
dc.description.abstractAIM: To determine the incidence, imaging findings and prognostic significance of cerebral metastases and other cerebral events in women with ovarian cancer. METHOD: A 5-year retrospective review of all women with ovarian cancer who had cranial imaging was undertaken at two major gynaecological oncology centers. RESULTS: Of 1222 women under clinical review, 78 underwent cranial imaging and 13 (1.1%) had cerebral metastasis. Computed tomography (CT) was diagnostic of parenchymal disease in 12 and magnetic resonance imaging (MRI) showed leptomeningeal disease in two. The women were aged between 23 and 73 years and all had stage III or IV disease at presentation. Cerebral metastasis occurred at 6-60 months from initial diagnosis, with death occurring predominantly within 12 months, but with five survivors at 4-45 months. Of the remaining 65 women, 10 had cerebrovascular disease and three had unrelated lesions. CONCLUSION: Cerebral metastasis remains a rare event in women with ovarian cancer but may be an isolated late event associated with survival beyond a year after neurosurgery and chemotherapy. CT should be the first investigation as the incidence of cerebrovascular disease is similar to that of metastatic disease.en
dc.language.isoenen
dc.subjectBrain Canceren
dc.subjectOvarian Canceren
dc.subjectCancer Stagingen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBrain Neoplasms-
dc.subject.meshEngland-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Staging-
dc.subject.meshOvarian Neoplasms-
dc.subject.meshPrognosis-
dc.subject.meshRetrospective Studies-
dc.subject.meshSurvival Rate-
dc.subject.meshTomography, X-Ray Computed-
dc.subject.meshTreatment Outcome-
dc.titleCerebral metastasis and other cerebral events in women with ovarian cancer.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Radiology and Medical Oncology, St James's University Hospital, Leeds, UK.en
dc.identifier.journalClinical Radiologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.