X-ray refraction effects: application to the imaging of biological tissues.

2.50
Hdl Handle:
http://hdl.handle.net/10541/79054
Title:
X-ray refraction effects: application to the imaging of biological tissues.
Authors:
Lewis, R A; Hall, C J; Hufton, Alan P; Evans, S; Menk, R H; Arfelli, F; Rigon, L; Tromba, G; Dance, D R; Ellis, I O; Evans, A; Jacobs, E; Pinder, S E; Rogers, K D
Abstract:
The purpose of this study was to explore the potential of refraction contrast X-ray imaging of biological tissues. Images of dissected mouse lungs, heart, liver and legs were produced using the medical beamline at the Elettra Synchrotron at Trieste, Italy. The technique used was diffraction enhanced imaging. This utilizes a silicon crystal positioned between the tissue sample and the detector to separate refracted X-rays from transmitted and scattered radiation by Bragg diffraction. The contrast in the images produced is related to changes in the X-ray refractive index of the tissues, resulting in remarkable clarity compared with conventional X-ray images based on absorption effects. These changes were greatest at the boundaries between different tissues, giving a marked edge enhancement effect and three-dimensional appearance to the images. The technique provides a way of imaging a property of biological tissues not yet exploited, and further studies are planned to identify specific applications in medical imaging.
Affiliation:
Daresbury Laboratory, Warrington WA4 4AD, UK.
Citation:
X-ray refraction effects: application to the imaging of biological tissues. 2003, 76 (905):301-8 Br J Radiol
Journal:
The British Journal of Radiology
Issue Date:
May-2003
URI:
http://hdl.handle.net/10541/79054
DOI:
10.1259/bjr/32889803
PubMed ID:
12763945
Type:
Article
Language:
en
ISSN:
0007-1285
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLewis, R A-
dc.contributor.authorHall, C J-
dc.contributor.authorHufton, Alan P-
dc.contributor.authorEvans, S-
dc.contributor.authorMenk, R H-
dc.contributor.authorArfelli, F-
dc.contributor.authorRigon, L-
dc.contributor.authorTromba, G-
dc.contributor.authorDance, D R-
dc.contributor.authorEllis, I O-
dc.contributor.authorEvans, A-
dc.contributor.authorJacobs, E-
dc.contributor.authorPinder, S E-
dc.contributor.authorRogers, K D-
dc.date.accessioned2009-08-28T08:37:09Z-
dc.date.available2009-08-28T08:37:09Z-
dc.date.issued2003-05-
dc.identifier.citationX-ray refraction effects: application to the imaging of biological tissues. 2003, 76 (905):301-8 Br J Radiolen
dc.identifier.issn0007-1285-
dc.identifier.pmid12763945-
dc.identifier.doi10.1259/bjr/32889803-
dc.identifier.urihttp://hdl.handle.net/10541/79054-
dc.description.abstractThe purpose of this study was to explore the potential of refraction contrast X-ray imaging of biological tissues. Images of dissected mouse lungs, heart, liver and legs were produced using the medical beamline at the Elettra Synchrotron at Trieste, Italy. The technique used was diffraction enhanced imaging. This utilizes a silicon crystal positioned between the tissue sample and the detector to separate refracted X-rays from transmitted and scattered radiation by Bragg diffraction. The contrast in the images produced is related to changes in the X-ray refractive index of the tissues, resulting in remarkable clarity compared with conventional X-ray images based on absorption effects. These changes were greatest at the boundaries between different tissues, giving a marked edge enhancement effect and three-dimensional appearance to the images. The technique provides a way of imaging a property of biological tissues not yet exploited, and further studies are planned to identify specific applications in medical imaging.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshExtremities-
dc.subject.meshFemale-
dc.subject.meshHeart-
dc.subject.meshLiver-
dc.subject.meshLung-
dc.subject.meshMice-
dc.subject.meshMice, Inbred BALB C-
dc.subject.meshRadiographic Image Enhancement-
dc.subject.meshScattering, Radiation-
dc.subject.meshTechnology, Radiologic-
dc.titleX-ray refraction effects: application to the imaging of biological tissues.en
dc.typeArticleen
dc.contributor.departmentDaresbury Laboratory, Warrington WA4 4AD, UK.en
dc.identifier.journalThe British Journal of Radiologyen

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