Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?

2.50
Hdl Handle:
http://hdl.handle.net/10541/79046
Title:
Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?
Authors:
Cooper, R; Sarioğlu, S; Sökmen, S; Füzün, M; Küpelioğlu, A; Valentine, Helen R; Görken, I B; Airley, R; West, Catharine M L
Abstract:
The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. A mean of three sections per tumour (range 1-12) were examined. Each section was semiquantitatively scored; 0, no staining; 1, <10%; 2, 10-50%; 3, >50% and a score given for the whole section, the superficial (luminal) and deep (mural) part of the tumour. Staining was seen in 70% of tumours. Increased staining was noted adjacent to necrosis and ulceration. A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen. Patients with high GLUT-1-expressing tumours (score 3 vs 0-2) had a significantly poorer overall survival (P=0.041), which was associated with poorer metastasis-free survival with no difference in local control. No significant correlation was seen with other prognostic factors. There was a strong correlation between the score for the superficial and deep parts of the tumour (r=0.81), but a significant relationship with outcome was only found in the deep part (P=0.003 vs P=0.46). In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy.
Affiliation:
Department of Radiation Oncology, Dokuz Eylül University Medical School, Inciraltu, Izmir 35340, Turkey. rachel.cooper@deu.edu.tr
Citation:
Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma? 2003, 89 (5):870-6 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
1-Sep-2003
URI:
http://hdl.handle.net/10541/79046
DOI:
10.1038/sj.bjc.6601202
PubMed ID:
12942120
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCooper, R-
dc.contributor.authorSarioğlu, S-
dc.contributor.authorSökmen, S-
dc.contributor.authorFüzün, M-
dc.contributor.authorKüpelioğlu, A-
dc.contributor.authorValentine, Helen R-
dc.contributor.authorGörken, I B-
dc.contributor.authorAirley, R-
dc.contributor.authorWest, Catharine M L-
dc.date.accessioned2009-08-28T10:11:55Z-
dc.date.available2009-08-28T10:11:55Z-
dc.date.issued2003-09-01-
dc.identifier.citationGlucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma? 2003, 89 (5):870-6 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid12942120-
dc.identifier.doi10.1038/sj.bjc.6601202-
dc.identifier.urihttp://hdl.handle.net/10541/79046-
dc.description.abstractThe aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. A mean of three sections per tumour (range 1-12) were examined. Each section was semiquantitatively scored; 0, no staining; 1, <10%; 2, 10-50%; 3, >50% and a score given for the whole section, the superficial (luminal) and deep (mural) part of the tumour. Staining was seen in 70% of tumours. Increased staining was noted adjacent to necrosis and ulceration. A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen. Patients with high GLUT-1-expressing tumours (score 3 vs 0-2) had a significantly poorer overall survival (P=0.041), which was associated with poorer metastasis-free survival with no difference in local control. No significant correlation was seen with other prognostic factors. There was a strong correlation between the score for the superficial and deep parts of the tumour (r=0.81), but a significant relationship with outcome was only found in the deep part (P=0.003 vs P=0.46). In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy.en
dc.language.isoenen
dc.subjectRectal Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshCarcinoma-
dc.subject.meshCell Hypoxia-
dc.subject.meshGlucose Transporter Type 1-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMonosaccharide Transport Proteins-
dc.subject.meshNecrosis-
dc.subject.meshPrognosis-
dc.subject.meshRectal Neoplasms-
dc.subject.meshSurvival Rate-
dc.subject.meshTumor Markers, Biological-
dc.titleGlucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiation Oncology, Dokuz Eylül University Medical School, Inciraltu, Izmir 35340, Turkey. rachel.cooper@deu.edu.tren
dc.identifier.journalBritish Journal of Canceren

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