Geographical and ecological analyses of childhood Wilms' tumours and soft-tissue sarcomas in North West England.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78981
Title:
Geographical and ecological analyses of childhood Wilms' tumours and soft-tissue sarcomas in North West England.
Authors:
McNally, Richard J Q; Alston, Robert D; Cairns, Donal P; Eden, Tim O B; Kelsey, Anna M; Birch, Jillian M
Abstract:
The aim of this paper was to study the geographical distribution of Wilms' tumours (WT) and soft-tissue sarcomas (STS) for 0-14 year olds included in a population-based registry from North West England during 1976-2000. Standardised morbidity ratios (SMRs) were calculated. Relationships between incidence rates and small area (ward) population density, ethnic composition, deprivation index and urban-rural status were examined using Poisson regression. There was a non-linear relationship between WT incidence and population density (P=0.008), with a higher incidence associated with wards with low deprivation scores (P=0.02); and which included a greater proportion of whites (P=0.01). For STS, a higher incidence was associated with wards with low deprivation scores (P=0.04); and which were 'more rural/less urban' (P=0.03). These results are consistent with a role for localised environmental exposures, in combination with lifestyle factors, in the aetiology of WT. For STS, there is some evidence for the involvement of environmental and/or lifestyle factors.
Affiliation:
Cancer Research UK Paediatric and Familial Cancer Research Group, Central Manchester and Manchester Children's University Hospitals NHS Trust, Manchester, UK. richard.mcnally@man.ac.uk
Citation:
Geographical and ecological analyses of childhood Wilms' tumours and soft-tissue sarcomas in North West England. 2003, 39 (11):1586-93 Eur. J. Cancer
Journal:
European Journal of Cancer
Issue Date:
Jul-2003
URI:
http://hdl.handle.net/10541/78981
DOI:
10.1016/S0959-8049(03)00357-5
PubMed ID:
12855266
Type:
Article
Language:
en
ISSN:
0959-8049
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMcNally, Richard J Q-
dc.contributor.authorAlston, Robert D-
dc.contributor.authorCairns, Donal P-
dc.contributor.authorEden, Tim O B-
dc.contributor.authorKelsey, Anna M-
dc.contributor.authorBirch, Jillian M-
dc.date.accessioned2009-08-27T16:00:34Z-
dc.date.available2009-08-27T16:00:34Z-
dc.date.issued2003-07-
dc.identifier.citationGeographical and ecological analyses of childhood Wilms' tumours and soft-tissue sarcomas in North West England. 2003, 39 (11):1586-93 Eur. J. Canceren
dc.identifier.issn0959-8049-
dc.identifier.pmid12855266-
dc.identifier.doi10.1016/S0959-8049(03)00357-5-
dc.identifier.urihttp://hdl.handle.net/10541/78981-
dc.description.abstractThe aim of this paper was to study the geographical distribution of Wilms' tumours (WT) and soft-tissue sarcomas (STS) for 0-14 year olds included in a population-based registry from North West England during 1976-2000. Standardised morbidity ratios (SMRs) were calculated. Relationships between incidence rates and small area (ward) population density, ethnic composition, deprivation index and urban-rural status were examined using Poisson regression. There was a non-linear relationship between WT incidence and population density (P=0.008), with a higher incidence associated with wards with low deprivation scores (P=0.02); and which included a greater proportion of whites (P=0.01). For STS, a higher incidence was associated with wards with low deprivation scores (P=0.04); and which were 'more rural/less urban' (P=0.03). These results are consistent with a role for localised environmental exposures, in combination with lifestyle factors, in the aetiology of WT. For STS, there is some evidence for the involvement of environmental and/or lifestyle factors.en
dc.language.isoenen
dc.subjectWilms Tumouren
dc.subject.meshAdolescent-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshEngland-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshInfant-
dc.subject.meshInfant, Newborn-
dc.subject.meshMale-
dc.subject.meshPoisson Distribution-
dc.subject.meshRegression Analysis-
dc.subject.meshResidence Characteristics-
dc.subject.meshRhabdomyosarcoma-
dc.subject.meshRural Health-
dc.subject.meshSarcoma-
dc.subject.meshSocioeconomic Factors-
dc.subject.meshUrban Health-
dc.subject.meshWilms Tumor-
dc.titleGeographical and ecological analyses of childhood Wilms' tumours and soft-tissue sarcomas in North West England.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Paediatric and Familial Cancer Research Group, Central Manchester and Manchester Children's University Hospitals NHS Trust, Manchester, UK. richard.mcnally@man.ac.uken
dc.identifier.journalEuropean Journal of Canceren

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