Short course para-aortic radiation for stage I seminoma of the testis.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78895
Title:
Short course para-aortic radiation for stage I seminoma of the testis.
Authors:
Logue, John P; Harris, Maggie A; Livsey, Jacqueline E; Swindell, Ric; Mobarek, Nabil; Read, G
Abstract:
PURPOSE: To determine the outcome in men with Stage I seminoma treated with low-dose para-aortic radiation. MATERIALS AND METHODS: Between January 1988 and December 2000, 431 men with Stage I seminoma were treated with para-aortic radiation to a midplane dose of 20 Gy in 8 fractions over 10 days. RESULTS: At a median follow-up of 62 months, 15 patients (3.5%) had relapsed, with a median time to relapse of 13 months (range: 9 to 39 months). Nine patients had pelvic nodal relapse; in addition, 1 patient had para-aortic involvement, and 2 had distant disease. Four had metastatic disease only (mediastinum 2, lung 2). One patient had scrotal recurrence, and 1 was treated for progressive rise in human chorionic gonadotrophin without identifiable disease. Initial treatment at relapse was chemotherapy (12), radiation (2), and surgery (1). One patient died from progressive disease. Thirteen men (3%) have developed second malignancies, including 7 contralateral testicular tumors, 5 solid malignancies, and 1 leukemia. The overall 5-year survival was 98%, and the estimated recurrence-free survival at 5 years was 96.3%. On log-rank univariate analysis, lymphovascular invasion, involvement of the tunica, and a preoperative human chorionic gonadotrophin level of greater than 5 were found to be of prognostic significance for recurrence. CONCLUSIONS: These data support short-duration, limited-field radiation as an optimal safe and effective protocol in the management of Stage I seminoma patients.
Affiliation:
Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester, United Kingdom. johnlogue@christie-tr.nwest.nhs.uk
Citation:
Short course para-aortic radiation for stage I seminoma of the testis. 2003, 57 (5):1304-9 Int J Radiat Oncol Biol Phys
Journal:
International Journal of Radiation Oncology, Biology, Physics
Issue Date:
1-Dec-2003
URI:
http://hdl.handle.net/10541/78895
DOI:
10.1016/S0360-3016(03)00754-5
PubMed ID:
14630266
Type:
Article
Language:
en
ISSN:
0360-3016
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLogue, John P-
dc.contributor.authorHarris, Maggie A-
dc.contributor.authorLivsey, Jacqueline E-
dc.contributor.authorSwindell, Ric-
dc.contributor.authorMobarek, Nabil-
dc.contributor.authorRead, G-
dc.date.accessioned2009-08-27T13:38:29Z-
dc.date.available2009-08-27T13:38:29Z-
dc.date.issued2003-12-01-
dc.identifier.citationShort course para-aortic radiation for stage I seminoma of the testis. 2003, 57 (5):1304-9 Int J Radiat Oncol Biol Physen
dc.identifier.issn0360-3016-
dc.identifier.pmid14630266-
dc.identifier.doi10.1016/S0360-3016(03)00754-5-
dc.identifier.urihttp://hdl.handle.net/10541/78895-
dc.description.abstractPURPOSE: To determine the outcome in men with Stage I seminoma treated with low-dose para-aortic radiation. MATERIALS AND METHODS: Between January 1988 and December 2000, 431 men with Stage I seminoma were treated with para-aortic radiation to a midplane dose of 20 Gy in 8 fractions over 10 days. RESULTS: At a median follow-up of 62 months, 15 patients (3.5%) had relapsed, with a median time to relapse of 13 months (range: 9 to 39 months). Nine patients had pelvic nodal relapse; in addition, 1 patient had para-aortic involvement, and 2 had distant disease. Four had metastatic disease only (mediastinum 2, lung 2). One patient had scrotal recurrence, and 1 was treated for progressive rise in human chorionic gonadotrophin without identifiable disease. Initial treatment at relapse was chemotherapy (12), radiation (2), and surgery (1). One patient died from progressive disease. Thirteen men (3%) have developed second malignancies, including 7 contralateral testicular tumors, 5 solid malignancies, and 1 leukemia. The overall 5-year survival was 98%, and the estimated recurrence-free survival at 5 years was 96.3%. On log-rank univariate analysis, lymphovascular invasion, involvement of the tunica, and a preoperative human chorionic gonadotrophin level of greater than 5 were found to be of prognostic significance for recurrence. CONCLUSIONS: These data support short-duration, limited-field radiation as an optimal safe and effective protocol in the management of Stage I seminoma patients.en
dc.language.isoenen
dc.subjectSecond Primary Canceren
dc.subjectCancer Stagingen
dc.subjectTesticular Canceren
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAnalysis of Variance-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Staging-
dc.subject.meshNeoplasms, Second Primary-
dc.subject.meshSeminoma-
dc.subject.meshTesticular Neoplasms-
dc.titleShort course para-aortic radiation for stage I seminoma of the testis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Christie Hospital NHS Trust, Manchester, United Kingdom. johnlogue@christie-tr.nwest.nhs.uken
dc.identifier.journalInternational Journal of Radiation Oncology, Biology, Physicsen

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