Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78804
Title:
Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy.
Authors:
Duff, Sarah E; Li, Chenggang; Jeziorska, M; Kumar, Shant; Saunders, Mark P; Sherlock, D; O'Dwyer, Sarah T; Jayson, Gordon C ( 0000-0002-8515-8944 )
Abstract:
Vascular endothelial growth factor-C (VEGF-C) and VEGF-D are members of the VEGF family of cytokines and have angiogenic and lymphangiogenic actions. In gastric adenocarcinoma, VEGF-C mRNA and tissue protein expression correlate with lymphatic invasion, lymph node metastasis and in some reports, venous invasion and reduced 5-year survival. Patients with gastric adenocarcinomas containing high levels of VEGF-C expression have significantly reduced 5-year survival rates, and VEGF-C expression is an independent prognostic risk factor for death. The role of VEGF-C in oesophageal squamous and colorectal cancer and VEGF-D in colorectal cancer is not clear, with conflicting reports in the published literature. In order to exploit potential therapeutic applications, further research is necessary to define the precise roles of these cytokines in health and disease.
Affiliation:
Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. sarah.duff@christie-tr.nwest.nhs.uk
Citation:
Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy. 2003, 89 (3):426-30 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
4-Aug-2003
URI:
http://hdl.handle.net/10541/78804
DOI:
10.1038/sj.bjc.6601145
PubMed ID:
12888807
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDuff, Sarah E-
dc.contributor.authorLi, Chenggang-
dc.contributor.authorJeziorska, M-
dc.contributor.authorKumar, Shant-
dc.contributor.authorSaunders, Mark P-
dc.contributor.authorSherlock, D-
dc.contributor.authorO'Dwyer, Sarah T-
dc.contributor.authorJayson, Gordon C-
dc.date.accessioned2009-08-27T09:55:01Z-
dc.date.available2009-08-27T09:55:01Z-
dc.date.issued2003-08-04-
dc.identifier.citationVascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy. 2003, 89 (3):426-30 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid12888807-
dc.identifier.doi10.1038/sj.bjc.6601145-
dc.identifier.urihttp://hdl.handle.net/10541/78804-
dc.description.abstractVascular endothelial growth factor-C (VEGF-C) and VEGF-D are members of the VEGF family of cytokines and have angiogenic and lymphangiogenic actions. In gastric adenocarcinoma, VEGF-C mRNA and tissue protein expression correlate with lymphatic invasion, lymph node metastasis and in some reports, venous invasion and reduced 5-year survival. Patients with gastric adenocarcinomas containing high levels of VEGF-C expression have significantly reduced 5-year survival rates, and VEGF-C expression is an independent prognostic risk factor for death. The role of VEGF-C in oesophageal squamous and colorectal cancer and VEGF-D in colorectal cancer is not clear, with conflicting reports in the published literature. In order to exploit potential therapeutic applications, further research is necessary to define the precise roles of these cytokines in health and disease.en
dc.language.isoenen
dc.subjectColorectal Canceren
dc.subjectOesophageal Canceren
dc.subjectStomach Canceren
dc.subjectCancer Invasivenessen
dc.subject.meshAdenocarcinoma-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshEndothelial Growth Factors-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshHumans-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshLymphatic System-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshNeovascularization, Pathologic-
dc.subject.meshPrognosis-
dc.subject.meshStomach Neoplasms-
dc.subject.meshSurvival Analysis-
dc.subject.meshVascular Endothelial Growth Factor C-
dc.subject.meshVascular Endothelial Growth Factor D-
dc.titleVascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. sarah.duff@christie-tr.nwest.nhs.uken
dc.identifier.journalBritish Journal of Canceren

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