Are BRCA1- and BRCA2-related breast cancers associated with increased mortality?

2.50
Hdl Handle:
http://hdl.handle.net/10541/78796
Title:
Are BRCA1- and BRCA2-related breast cancers associated with increased mortality?
Authors:
Evans, D Gareth R; Howell, Anthony ( 0000-0002-3879-5991 )
Abstract:
There has been contradictory evidence as to whether BRCA1 associated breast cancers have a poorer prognosis than non-BRCA1 cancers. In this issue of Breast Cancer Research Robson and colleagues provide further evidence for poorer survival in BRCA1 carriers and show that it could be attributed to failure to treat small node-negative grade 3 breast cancers with chemotherapy. There still remains little evidence for a survival difference for BRCA2 related breast cancers. Although the high contralateral breast cancer risk is confirmed by this study there is no real evidence for an increase in ipsilateral recurrence or new primary breast cancers in mutation carriers up to the 10-year point.
Affiliation:
Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Manchester, UK. Gareth.Evans@CMMC.nhs.uk
Citation:
Are BRCA1- and BRCA2-related breast cancers associated with increased mortality? 2004, 6 (1):E7 Breast Cancer Res.
Journal:
Breast Cancer Research
Issue Date:
2004
URI:
http://hdl.handle.net/10541/78796
DOI:
10.1186/bcr748
PubMed ID:
14680492
Type:
Article
Language:
en
ISSN:
1465-542X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEvans, D Gareth R-
dc.contributor.authorHowell, Anthony-
dc.date.accessioned2009-08-27T08:27:16Z-
dc.date.available2009-08-27T08:27:16Z-
dc.date.issued2004-
dc.identifier.citationAre BRCA1- and BRCA2-related breast cancers associated with increased mortality? 2004, 6 (1):E7 Breast Cancer Res.en
dc.identifier.issn1465-542X-
dc.identifier.pmid14680492-
dc.identifier.doi10.1186/bcr748-
dc.identifier.urihttp://hdl.handle.net/10541/78796-
dc.description.abstractThere has been contradictory evidence as to whether BRCA1 associated breast cancers have a poorer prognosis than non-BRCA1 cancers. In this issue of Breast Cancer Research Robson and colleagues provide further evidence for poorer survival in BRCA1 carriers and show that it could be attributed to failure to treat small node-negative grade 3 breast cancers with chemotherapy. There still remains little evidence for a survival difference for BRCA2 related breast cancers. Although the high contralateral breast cancer risk is confirmed by this study there is no real evidence for an increase in ipsilateral recurrence or new primary breast cancers in mutation carriers up to the 10-year point.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshBRCA1 Protein-
dc.subject.meshBRCA2 Protein-
dc.subject.meshBreast Neoplasms-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGerm-Line Mutation-
dc.subject.meshHumans-
dc.subject.meshMultivariate Analysis-
dc.subject.meshRisk Factors-
dc.subject.meshSurvival Analysis-
dc.subject.meshTime Factors-
dc.titleAre BRCA1- and BRCA2-related breast cancers associated with increased mortality?en
dc.typeArticleen
dc.contributor.departmentAcademic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Manchester, UK. Gareth.Evans@CMMC.nhs.uken
dc.identifier.journalBreast Cancer Researchen

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