Breast density and breast cancer risk factors in a high-risk population.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78795
Title:
Breast density and breast cancer risk factors in a high-risk population.
Authors:
Warwick, J; Pinney, E; Warren, R; Duffy, Stephen W; Howell, Anthony ( 0000-0002-3879-5991 ) ; Wilson, M; Cuzick, Jack
Abstract:
This study investigates relationships between familial and hormonal risk factors and breast density in women at high risk of developing breast cancer. The subjects are a subset of 102 women from the international breast cancer intervention study (IBIS), for whom a series of repeated measurements of breast density were available. Details of familial and hormonal risk factors for breast cancer were collected at entry and multivariate ordered logistic regression used to identify risk factors for increased breast density. Lower body mass index and nulliparity were associated with high breast density, whereas smoking was associated with lower breast density. It is not yet known whether a reduction in breast density will lead to a corresponding reduction in breast cancer risk, so we propose that changes in breast density be investigated as a potential early indicator of efficacy in chemoprevention trials for breast cancer.
Affiliation:
Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London WC2A 3PX, UK. jane.warwick@cancer.org.uk
Citation:
Breast density and breast cancer risk factors in a high-risk population. 2003, 12 (1):10-6 Breast
Journal:
Breast
Issue Date:
Feb-2003
URI:
http://hdl.handle.net/10541/78795
DOI:
10.1016/S0960-9776(02)00212-6
PubMed ID:
14659350
Type:
Article
Language:
en
ISSN:
0960-9776
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorWarwick, J-
dc.contributor.authorPinney, E-
dc.contributor.authorWarren, R-
dc.contributor.authorDuffy, Stephen W-
dc.contributor.authorHowell, Anthony-
dc.contributor.authorWilson, M-
dc.contributor.authorCuzick, Jack-
dc.date.accessioned2009-08-27T08:23:53Z-
dc.date.available2009-08-27T08:23:53Z-
dc.date.issued2003-02-
dc.identifier.citationBreast density and breast cancer risk factors in a high-risk population. 2003, 12 (1):10-6 Breasten
dc.identifier.issn0960-9776-
dc.identifier.pmid14659350-
dc.identifier.doi10.1016/S0960-9776(02)00212-6-
dc.identifier.urihttp://hdl.handle.net/10541/78795-
dc.description.abstractThis study investigates relationships between familial and hormonal risk factors and breast density in women at high risk of developing breast cancer. The subjects are a subset of 102 women from the international breast cancer intervention study (IBIS), for whom a series of repeated measurements of breast density were available. Details of familial and hormonal risk factors for breast cancer were collected at entry and multivariate ordered logistic regression used to identify risk factors for increased breast density. Lower body mass index and nulliparity were associated with high breast density, whereas smoking was associated with lower breast density. It is not yet known whether a reduction in breast density will lead to a corresponding reduction in breast cancer risk, so we propose that changes in breast density be investigated as a potential early indicator of efficacy in chemoprevention trials for breast cancer.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshBody Mass Index-
dc.subject.meshBreast-
dc.subject.meshBreast Neoplasms-
dc.subject.meshChemoprevention-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMammography-
dc.subject.meshMass Screening-
dc.subject.meshMiddle Aged-
dc.subject.meshParity-
dc.subject.meshRisk Assessment-
dc.subject.meshRisk Factors-
dc.subject.meshSmoking-
dc.subject.meshTamoxifen-
dc.subject.meshWomen-
dc.titleBreast density and breast cancer risk factors in a high-risk population.en
dc.typeArticleen
dc.contributor.departmentDepartment of Mathematics, Statistics and Epidemiology, Cancer Research UK, London WC2A 3PX, UK. jane.warwick@cancer.org.uken
dc.identifier.journalBreasten

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