2.50
Hdl Handle:
http://hdl.handle.net/10541/78477
Title:
Pathbase: a database of mutant mouse pathology.
Authors:
Schofield, Paul N; Bard, Jonathan B L; Booth, Catherine; Boniver, Jacques; Covelli, Vincenzo; Delvenne, Philippe; Ellender, Michele; Engstrom, Wilhelm; Goessner, Wolfgang; Gruenberger, Michael; Hoefler, Heinz; Hopewell, John; Mancuso, Mariatheresa; Mothersill, Carmel; Potten, Christopher S; Quintanilla-Fend, Leticia; Rozell, Bjorn; Sariola, Hannu; Sundberg, John P; Ward, Andrew D
Abstract:
Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain-dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high-resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources.
Affiliation:
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. ps@mole.bio.cam.ac.uk
Citation:
Pathbase: a database of mutant mouse pathology. 2004, 32 (Database issue):D512-5 Nucleic Acids Res.
Journal:
Nucleic Acids Research
Issue Date:
1-Jan-2004
URI:
http://hdl.handle.net/10541/78477
DOI:
10.1093/nar/gkh124
PubMed ID:
14681470
Type:
Article
Language:
en
ISSN:
1362-4962
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSchofield, Paul N-
dc.contributor.authorBard, Jonathan B L-
dc.contributor.authorBooth, Catherine-
dc.contributor.authorBoniver, Jacques-
dc.contributor.authorCovelli, Vincenzo-
dc.contributor.authorDelvenne, Philippe-
dc.contributor.authorEllender, Michele-
dc.contributor.authorEngstrom, Wilhelm-
dc.contributor.authorGoessner, Wolfgang-
dc.contributor.authorGruenberger, Michael-
dc.contributor.authorHoefler, Heinz-
dc.contributor.authorHopewell, John-
dc.contributor.authorMancuso, Mariatheresa-
dc.contributor.authorMothersill, Carmel-
dc.contributor.authorPotten, Christopher S-
dc.contributor.authorQuintanilla-Fend, Leticia-
dc.contributor.authorRozell, Bjorn-
dc.contributor.authorSariola, Hannu-
dc.contributor.authorSundberg, John P-
dc.contributor.authorWard, Andrew D-
dc.date.accessioned2009-08-25T11:33:29Z-
dc.date.available2009-08-25T11:33:29Z-
dc.date.issued2004-01-01-
dc.identifier.citationPathbase: a database of mutant mouse pathology. 2004, 32 (Database issue):D512-5 Nucleic Acids Res.en
dc.identifier.issn1362-4962-
dc.identifier.pmid14681470-
dc.identifier.doi10.1093/nar/gkh124-
dc.identifier.urihttp://hdl.handle.net/10541/78477-
dc.description.abstractPathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain-dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high-resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshComputational Biology-
dc.subject.meshDatabases, Factual-
dc.subject.meshDisease-
dc.subject.meshGenotype-
dc.subject.meshInformation Storage and Retrieval-
dc.subject.meshInternet-
dc.subject.meshMice-
dc.subject.meshMutation-
dc.subject.meshPathology-
dc.subject.meshPhenotype-
dc.subject.meshVocabulary, Controlled-
dc.titlePathbase: a database of mutant mouse pathology.en
dc.typeArticleen
dc.contributor.departmentDepartment of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. ps@mole.bio.cam.ac.uken
dc.identifier.journalNucleic Acids Researchen

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