2.50
Hdl Handle:
http://hdl.handle.net/10541/78442
Title:
Protection and selection for gene therapy in the hematopoietic system.
Authors:
Milsom, Michael D; Fairbairn, Leslie J
Abstract:
Hematopoietic stem cell gene therapy is potentially curative for a number of inherited and acquired disorders. However, poor gene transfer and expression in repopulating hematopoietic stem cells attenuate this potential. Here we review potential means of conferring a selective advantage to hematopoietic stem cells and their progeny, and discuss the issues that surround the use of selective advantages in vivo.
Affiliation:
Cancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.
Citation:
Protection and selection for gene therapy in the hematopoietic system. 2004, 6 (2):133-46 J Gene Med
Journal:
The Journal of Gene Medicine
Issue Date:
Feb-2004
URI:
http://hdl.handle.net/10541/78442
DOI:
10.1002/jgm.533
PubMed ID:
14978767
Type:
Article
Language:
en
ISSN:
1099-498X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMilsom, Michael D-
dc.contributor.authorFairbairn, Leslie J-
dc.date.accessioned2009-08-25T11:04:22Z-
dc.date.available2009-08-25T11:04:22Z-
dc.date.issued2004-02-
dc.identifier.citationProtection and selection for gene therapy in the hematopoietic system. 2004, 6 (2):133-46 J Gene Meden
dc.identifier.issn1099-498X-
dc.identifier.pmid14978767-
dc.identifier.doi10.1002/jgm.533-
dc.identifier.urihttp://hdl.handle.net/10541/78442-
dc.description.abstractHematopoietic stem cell gene therapy is potentially curative for a number of inherited and acquired disorders. However, poor gene transfer and expression in repopulating hematopoietic stem cells attenuate this potential. Here we review potential means of conferring a selective advantage to hematopoietic stem cells and their progeny, and discuss the issues that surround the use of selective advantages in vivo.en
dc.language.isoenen
dc.subjectHaematopoietic Systemen
dc.subject.meshATP-Binding Cassette Transporters-
dc.subject.meshAnimals-
dc.subject.meshDNA Modification Methylases-
dc.subject.meshDNA Repair-
dc.subject.meshDrug Resistance-
dc.subject.meshGene Therapy-
dc.subject.meshHematopoietic System-
dc.subject.meshHomeodomain Proteins-
dc.subject.meshHumans-
dc.subject.meshTetrahydrofolate Dehydrogenase-
dc.subject.meshTranscription Factors-
dc.titleProtection and selection for gene therapy in the hematopoietic system.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.en
dc.identifier.journalThe Journal of Gene Medicineen

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