2.50
Hdl Handle:
http://hdl.handle.net/10541/78374
Title:
Proteomics techniques and their application to hematology.
Authors:
Cristea, Ileana M; Gaskell, Simon J; Whetton, Anthony D
Abstract:
The recent sequencing of a number of genomes has raised the level of opportunities for studies on proteins. This area of research has been described with the all-embracing term, proteomics. In proteomics, the use of mass spectrometric techniques enables genomic databases to be used to establish the identity of proteins with relatively little data, compared to the era before genome sequencing. The use of related analytical techniques also offers the opportunity to gain information on regulation, via posttranslational modification, and potential new diagnostic and prognostic indicators. Relative quantification of proteins and peptides in cellular and extracellular material remains a challenge for proteomics and mass spectrometry. This review presents an analysis of the present and future impact of these proteomic technologies with emphasis on relative quantification for hematologic research giving an appraisal of their potential benefits.
Affiliation:
Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester, United Kingdom.
Citation:
Proteomics techniques and their application to hematology. 2004, 103 (10):3624-34 Blood
Journal:
Blood
Issue Date:
15-May-2004
URI:
http://hdl.handle.net/10541/78374
DOI:
10.1182/blood-2003-09-3295
PubMed ID:
14726377
Type:
Article
Language:
en
ISSN:
0006-4971
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorCristea, Ileana M-
dc.contributor.authorGaskell, Simon J-
dc.contributor.authorWhetton, Anthony D-
dc.date.accessioned2009-08-24T14:10:34Z-
dc.date.available2009-08-24T14:10:34Z-
dc.date.issued2004-05-15-
dc.identifier.citationProteomics techniques and their application to hematology. 2004, 103 (10):3624-34 Blooden
dc.identifier.issn0006-4971-
dc.identifier.pmid14726377-
dc.identifier.doi10.1182/blood-2003-09-3295-
dc.identifier.urihttp://hdl.handle.net/10541/78374-
dc.description.abstractThe recent sequencing of a number of genomes has raised the level of opportunities for studies on proteins. This area of research has been described with the all-embracing term, proteomics. In proteomics, the use of mass spectrometric techniques enables genomic databases to be used to establish the identity of proteins with relatively little data, compared to the era before genome sequencing. The use of related analytical techniques also offers the opportunity to gain information on regulation, via posttranslational modification, and potential new diagnostic and prognostic indicators. Relative quantification of proteins and peptides in cellular and extracellular material remains a challenge for proteomics and mass spectrometry. This review presents an analysis of the present and future impact of these proteomic technologies with emphasis on relative quantification for hematologic research giving an appraisal of their potential benefits.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshElectrophoresis, Gel, Two-Dimensional-
dc.subject.meshHematology-
dc.subject.meshHumans-
dc.subject.meshMass Spectrometry-
dc.subject.meshProtein Array Analysis-
dc.subject.meshProtein Processing, Post-Translational-
dc.subject.meshProteins-
dc.subject.meshProteomics-
dc.subject.meshSequence Analysis-
dc.titleProteomics techniques and their application to hematology.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester, United Kingdom.en
dc.identifier.journalBlooden

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