2.50
Hdl Handle:
http://hdl.handle.net/10541/78373
Title:
A [17F]-fluoromethane PET/TMS study of effective connectivity.
Authors:
Ferrarelli, Fabio; Haraldsson, H Magnus; Barnhart, Todd E; Roberts, Andy D; Oakes, Terrence R; Massimini, Marcello; Stone, Charles K; Kalin, Ned H; Tononi, Giulio
Abstract:
We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [17F]-[CH3F] ([17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [15O]-H2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits.
Affiliation:
Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Blvd., Madison, WI 53719, USA.
Citation:
A [17F]-fluoromethane PET/TMS study of effective connectivity. 2004, 64 (2):103-13 Brain Res. Bull.
Journal:
Brain Research Bulletin
Issue Date:
30-Aug-2004
URI:
http://hdl.handle.net/10541/78373
DOI:
10.1016/j.brainresbull.2004.04.020
PubMed ID:
15342097
Type:
Article
Language:
en
ISSN:
0361-9230
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorFerrarelli, Fabio-
dc.contributor.authorHaraldsson, H Magnus-
dc.contributor.authorBarnhart, Todd E-
dc.contributor.authorRoberts, Andy D-
dc.contributor.authorOakes, Terrence R-
dc.contributor.authorMassimini, Marcello-
dc.contributor.authorStone, Charles K-
dc.contributor.authorKalin, Ned H-
dc.contributor.authorTononi, Giulio-
dc.date.accessioned2009-08-24T14:09:31Z-
dc.date.available2009-08-24T14:09:31Z-
dc.date.issued2004-08-30-
dc.identifier.citationA [17F]-fluoromethane PET/TMS study of effective connectivity. 2004, 64 (2):103-13 Brain Res. Bull.en
dc.identifier.issn0361-9230-
dc.identifier.pmid15342097-
dc.identifier.doi10.1016/j.brainresbull.2004.04.020-
dc.identifier.urihttp://hdl.handle.net/10541/78373-
dc.description.abstractWe used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [17F]-[CH3F] ([17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [15O]-H2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshBrain Mapping-
dc.subject.meshCerebral Cortex-
dc.subject.meshElectric Stimulation-
dc.subject.meshHumans-
dc.subject.meshHydrocarbons, Fluorinated-
dc.subject.meshImage Processing, Computer-Assisted-
dc.subject.meshMagnetics-
dc.subject.meshMale-
dc.subject.meshNeural Networks (Computer)-
dc.subject.meshPositron-Emission Tomography-
dc.titleA [17F]-fluoromethane PET/TMS study of effective connectivity.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Blvd., Madison, WI 53719, USA.en
dc.identifier.journalBrain Research Bulletinen

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