2.50
Hdl Handle:
http://hdl.handle.net/10541/78371
Title:
Genetic manipulation of drug sensitivity in haematopoietic cells.
Authors:
Southgate, Thomas D; Fairbairn, Leslie J
Abstract:
The haematopoietic system can be manipulated genetically to increase either its resistance to drugs or its sensitivity to certain agents. Gene transfer and expression of specific drug-resistance factors might protect haematopoietic function during antitumour chemotherapy, or allow enrichment of gene-modified cells in vivo. By contrast, gene transfer of a prodrug activator, to confer sensitivity to otherwise nontoxic prodrugs, might allow deletion of engrafted cells in the event of an adverse effect such as graft-versus-host disease or the induction of a neoplasm. In addition, expression of a prodrug activator in tumour-infiltrating haematopoietic cells could provide a means of specifically activating a cytotoxic agent within a tumour mass.
Affiliation:
Cancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK. tsouthgate@picr.man.ac.uk
Citation:
Genetic manipulation of drug sensitivity in haematopoietic cells. 2004, 6 (18):1-24 Expert Rev Mol Med
Journal:
Expert Reviews in Molecular Medicine
Issue Date:
6-Aug-2004
URI:
http://hdl.handle.net/10541/78371
DOI:
10.1017/S146239940400818X
PubMed ID:
15387894
Type:
Article
Language:
en
ISSN:
1462-3994
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSouthgate, Thomas D-
dc.contributor.authorFairbairn, Leslie J-
dc.date.accessioned2009-08-24T16:22:15Z-
dc.date.available2009-08-24T16:22:15Z-
dc.date.issued2004-08-06-
dc.identifier.citationGenetic manipulation of drug sensitivity in haematopoietic cells. 2004, 6 (18):1-24 Expert Rev Mol Meden
dc.identifier.issn1462-3994-
dc.identifier.pmid15387894-
dc.identifier.doi10.1017/S146239940400818X-
dc.identifier.urihttp://hdl.handle.net/10541/78371-
dc.description.abstractThe haematopoietic system can be manipulated genetically to increase either its resistance to drugs or its sensitivity to certain agents. Gene transfer and expression of specific drug-resistance factors might protect haematopoietic function during antitumour chemotherapy, or allow enrichment of gene-modified cells in vivo. By contrast, gene transfer of a prodrug activator, to confer sensitivity to otherwise nontoxic prodrugs, might allow deletion of engrafted cells in the event of an adverse effect such as graft-versus-host disease or the induction of a neoplasm. In addition, expression of a prodrug activator in tumour-infiltrating haematopoietic cells could provide a means of specifically activating a cytotoxic agent within a tumour mass.en
dc.language.isoenen
dc.subjectHaematopoietic Stem Cell Transplantationen
dc.subjectHaematopoietic Stem Cellsen
dc.subjectTumour Suppressor Proteinsen
dc.subject.meshAnimals-
dc.subject.meshBone Marrow Cells-
dc.subject.meshDNA Modification Methylases-
dc.subject.meshDNA Repair Enzymes-
dc.subject.meshDrug Resistance, Neoplasm-
dc.subject.meshGene Therapy-
dc.subject.meshGenes, MDR-
dc.subject.meshGenes, Transgenic, Suicide-
dc.subject.meshHematopoietic Stem Cell Transplantation-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshHumans-
dc.subject.meshMacrophages-
dc.subject.meshModels, Biological-
dc.subject.meshProtein Engineering-
dc.subject.meshTumor Suppressor Proteins-
dc.titleGenetic manipulation of drug sensitivity in haematopoietic cells.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK. tsouthgate@picr.man.ac.uken
dc.identifier.journalExpert Reviews in Molecular Medicineen

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