Adoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78365
Title:
Adoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma.
Authors:
Armstrong, Anne C; Dermime, Said; Mulryan, Kate; Stern, Peter L; Bhattacharyya, Tapan; Hawkins, Robert E
Abstract:
There is extensive interest in idiotypic vaccination as a treatment of lymphoma. An alternative approach is the adoptive transfer of in vitro generated T cells. This strategy has been used to treat posttransplantation EBV-related diseases. The ability to generate in vitro T cells to peptides derived from immunoglobulin idiotypes raises the possibility of directly using such cells as a treatment of lymphoma. Investigating the adoptive transfer of specific T cells to idiotype derived peptides in a murine lymphoma model is therefore an important part of the clinical translation of this alternative approach. We have generated an idiotype-specific T cell line, able to recognise a defined, naturally processed idiotype-derived epitope. This line has been used to successfully treat mice with disseminated lymphoma supporting the clinical use of idiotype specific T cells.
Affiliation:
Cancer Research UK Department of Medical Oncology, Paterson Institute of Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Adoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma., 27 (3):227-31 J. Immunother.
Journal:
Journal of Immunotherapy
Issue Date:
24-Aug-2009
URI:
http://hdl.handle.net/10541/78365
PubMed ID:
15076140
Language:
en
ISSN:
1524-9557
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorArmstrong, Anne C-
dc.contributor.authorDermime, Said-
dc.contributor.authorMulryan, Kate-
dc.contributor.authorStern, Peter L-
dc.contributor.authorBhattacharyya, Tapan-
dc.contributor.authorHawkins, Robert E-
dc.date.accessioned2009-08-24T16:10:55Z-
dc.date.available2009-08-24T16:10:55Z-
dc.date.issued2009-08-24T16:10:55Z-
dc.identifier.citationAdoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma., 27 (3):227-31 J. Immunother.en
dc.identifier.issn1524-9557-
dc.identifier.pmid15076140-
dc.identifier.urihttp://hdl.handle.net/10541/78365-
dc.description.abstractThere is extensive interest in idiotypic vaccination as a treatment of lymphoma. An alternative approach is the adoptive transfer of in vitro generated T cells. This strategy has been used to treat posttransplantation EBV-related diseases. The ability to generate in vitro T cells to peptides derived from immunoglobulin idiotypes raises the possibility of directly using such cells as a treatment of lymphoma. Investigating the adoptive transfer of specific T cells to idiotype derived peptides in a murine lymphoma model is therefore an important part of the clinical translation of this alternative approach. We have generated an idiotype-specific T cell line, able to recognise a defined, naturally processed idiotype-derived epitope. This line has been used to successfully treat mice with disseminated lymphoma supporting the clinical use of idiotype specific T cells.en
dc.language.isoenen
dc.subjectCell Line Tumouren
dc.subject.meshAdenoviridae-
dc.subject.meshAdoptive Transfer-
dc.subject.meshAnimals-
dc.subject.meshCell Division-
dc.subject.meshCell Line, Tumor-
dc.subject.meshChromium-
dc.subject.meshEnzyme-Linked Immunosorbent Assay-
dc.subject.meshEpitopes-
dc.subject.meshFemale-
dc.subject.meshImmunoglobulin Fragments-
dc.subject.meshImmunoglobulin Idiotypes-
dc.subject.meshImmunoglobulins-
dc.subject.meshImmunotherapy-
dc.subject.meshImmunotherapy, Adoptive-
dc.subject.meshInterferon-gamma-
dc.subject.meshLymphoma-
dc.subject.meshLymphoma, B-Cell-
dc.subject.meshMice-
dc.subject.meshMice, Inbred BALB C-
dc.subject.meshPeptides-
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction-
dc.subject.meshT-Lymphocytes-
dc.subject.meshTime Factors-
dc.titleAdoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma.en
dc.contributor.departmentCancer Research UK Department of Medical Oncology, Paterson Institute of Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalJournal of Immunotherapyen

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