The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78362
Title:
The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin.
Authors:
Verschuren, Emmy W; Jones, Nic; Evan, Gerard I
Abstract:
A timely coordination of cellular DNA synthesis and division cycles is governed by the temporal and spatial activation of cyclin-dependent kinases (Cdks). The primary regulation of Cdk activation is through binding to partner cyclin proteins. Several gammaherpesviruses encode a viral homologue of cellular cyclin D, which may function to deregulate host cell cycle progression. One of these is encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) and is called K cyclin or viral cyclin (v-cyclin). v-Cyclin is expressed in most of the malignant cells that are associated with KSHV infection in humans, labelling v-cyclin as a putative viral oncogene. Here are described some of the major structural and functional properties of mammalian cyclin/Cdk complexes, some of which are phenocopied by v-cyclin. In addition, the molecular events leading to orderly progression through the G(1)/S and G/M cell cycle phases are reviewed. This molecular picture serves as a platform on which to explain v-cyclin-specific functional properties. Interesting but largely speculative issues concern the interplay between v-cyclin-mediated cell cycle deregulation and molecular progression of KSHV-associated neoplasms.
Affiliation:
Stanford University, Pathology Department, 300 Pasteur Drive, MC 5324, Stanford, CA 94305, USA.
Citation:
The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. 2004, 85 (Pt 6):1347-61 J. Gen. Virol.
Journal:
The Journal of General Virology
Issue Date:
Jun-2004
URI:
http://hdl.handle.net/10541/78362
PubMed ID:
15166416
Type:
Article
Language:
en
ISSN:
0022-1317
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorVerschuren, Emmy W-
dc.contributor.authorJones, Nic-
dc.contributor.authorEvan, Gerard I-
dc.date.accessioned2009-08-24T15:56:03Z-
dc.date.available2009-08-24T15:56:03Z-
dc.date.issued2004-06-
dc.identifier.citationThe cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. 2004, 85 (Pt 6):1347-61 J. Gen. Virol.en
dc.identifier.issn0022-1317-
dc.identifier.pmid15166416-
dc.identifier.urihttp://hdl.handle.net/10541/78362-
dc.description.abstractA timely coordination of cellular DNA synthesis and division cycles is governed by the temporal and spatial activation of cyclin-dependent kinases (Cdks). The primary regulation of Cdk activation is through binding to partner cyclin proteins. Several gammaherpesviruses encode a viral homologue of cellular cyclin D, which may function to deregulate host cell cycle progression. One of these is encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) and is called K cyclin or viral cyclin (v-cyclin). v-Cyclin is expressed in most of the malignant cells that are associated with KSHV infection in humans, labelling v-cyclin as a putative viral oncogene. Here are described some of the major structural and functional properties of mammalian cyclin/Cdk complexes, some of which are phenocopied by v-cyclin. In addition, the molecular events leading to orderly progression through the G(1)/S and G/M cell cycle phases are reviewed. This molecular picture serves as a platform on which to explain v-cyclin-specific functional properties. Interesting but largely speculative issues concern the interplay between v-cyclin-mediated cell cycle deregulation and molecular progression of KSHV-associated neoplasms.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCatalytic Domain-
dc.subject.meshCell Cycle-
dc.subject.meshCell Cycle Proteins-
dc.subject.meshCyclin-Dependent Kinases-
dc.subject.meshCyclins-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshE2F Transcription Factors-
dc.subject.meshEnzyme Activation-
dc.subject.meshHerpesvirus 8, Human-
dc.subject.meshHumans-
dc.subject.meshMitosis-
dc.subject.meshPhosphorylation-
dc.subject.meshRetinoblastoma Protein-
dc.subject.meshTranscription Factors-
dc.subject.meshViral Proteins-
dc.titleThe cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin.en
dc.typeArticleen
dc.contributor.departmentStanford University, Pathology Department, 300 Pasteur Drive, MC 5324, Stanford, CA 94305, USA.en
dc.identifier.journalThe Journal of General Virologyen

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