Growth hormone replacement therapy (GHRT) in children and adolescents: skeletal impact.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78235
Title:
Growth hormone replacement therapy (GHRT) in children and adolescents: skeletal impact.
Authors:
Mukherjee, Annice; Shalet, Stephen M
Abstract:
In addition to its well-established effects on linear growth in childhood and adolescence, growth hormone has both direct and indirect actions on bone remodelling and homeostasis. In this review the limitations of methods of assessment of bone mineral density are highlighted. The influence of growth hormone deficiency of childhood-onset, on bone mineral accretion and, the specific skeletal implications of GHD in long-term survivors of childhood cancers, are discussed. Specific influential factors, which affect peak bone mass achievement and therefore skeletal health in later life, are evaluated.
Affiliation:
Department of Endocrinology, Christie Hospital, Withington, Manchester, United Kingdom.
Citation:
Growth hormone replacement therapy (GHRT) in children and adolescents: skeletal impact. 2003, 41 (3):235-42 Med. Pediatr. Oncol.
Journal:
Medical and Pediatric Oncology
Issue Date:
Sep-2003
URI:
http://hdl.handle.net/10541/78235
DOI:
10.1002/mpo.10343
PubMed ID:
12868125
Type:
Article
Language:
en
ISSN:
0098-1532
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMukherjee, Annice-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-08-21T14:19:22Z-
dc.date.available2009-08-21T14:19:22Z-
dc.date.issued2003-09-
dc.identifier.citationGrowth hormone replacement therapy (GHRT) in children and adolescents: skeletal impact. 2003, 41 (3):235-42 Med. Pediatr. Oncol.en
dc.identifier.issn0098-1532-
dc.identifier.pmid12868125-
dc.identifier.doi10.1002/mpo.10343-
dc.identifier.urihttp://hdl.handle.net/10541/78235-
dc.description.abstractIn addition to its well-established effects on linear growth in childhood and adolescence, growth hormone has both direct and indirect actions on bone remodelling and homeostasis. In this review the limitations of methods of assessment of bone mineral density are highlighted. The influence of growth hormone deficiency of childhood-onset, on bone mineral accretion and, the specific skeletal implications of GHD in long-term survivors of childhood cancers, are discussed. Specific influential factors, which affect peak bone mass achievement and therefore skeletal health in later life, are evaluated.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAging-
dc.subject.meshBone Density-
dc.subject.meshBone Development-
dc.subject.meshBone Remodeling-
dc.subject.meshFemale-
dc.subject.meshGrowth Disorders-
dc.subject.meshHormone Replacement Therapy-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshHypopituitarism-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms-
dc.titleGrowth hormone replacement therapy (GHRT) in children and adolescents: skeletal impact.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Withington, Manchester, United Kingdom.en
dc.identifier.journalMedical and Pediatric Oncologyen

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