Low-grade malignant Triton tumor of the oral cavity: a case report.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78227
Title:
Low-grade malignant Triton tumor of the oral cavity: a case report.
Authors:
James, Jacqueline A; Bali, Navjit S; Sloan, Philip; Shanks, Jonathan H
Abstract:
Malignant Triton tumor (MTT) is a malignant peripheral nerve sheath tumor showing rhabdomyoblastic differentiation. It is considered a high-grade neoplasm with poor outcome. This report describes an MTT appearing in the oral cavity. On histologic examination the encapsulated lesion was composed of interlacing fascicles of spindle cells and scattered, large, strap-like pleomorphic cells with abundant eosinophilic cytoplasm. No cross striations were seen. Examination of levels through the tissue showed a total of only 4 normal mitoses and no necrosis. Immunohistochemistry demonstrated diffuse S100 positivity in the spindle cells. The large pleomorphic cells were weakly positive for alpha-sarcomeric actin and myoglobin, although variably but strongly positive for desmin. Management involved a small en bloc resection of the maxilla. After 33 months there was no sign of recurrence or distant metastasis. It was concluded that low-grade variants of MTT occur that do not have an aggressive clinical course.
Affiliation:
University Dental Hospital of Manchester, Manchester, United Kingdom. jamesj@fsl.den.man.ac.uk
Citation:
Low-grade malignant Triton tumor of the oral cavity: a case report. 2003, 95 (6):699-704 Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Journal:
Oral surgery, Oral medicine, Oral pathology, Oral radiology, and Endodontics
Issue Date:
Jun-2003
URI:
http://hdl.handle.net/10541/78227
DOI:
10.1067/moe.2003.140
PubMed ID:
12789151
Type:
Article
Language:
en
ISSN:
1079-2104
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJames, Jacqueline A-
dc.contributor.authorBali, Navjit S-
dc.contributor.authorSloan, Philip-
dc.contributor.authorShanks, Jonathan H-
dc.date.accessioned2009-08-21T14:31:58Z-
dc.date.available2009-08-21T14:31:58Z-
dc.date.issued2003-06-
dc.identifier.citationLow-grade malignant Triton tumor of the oral cavity: a case report. 2003, 95 (6):699-704 Oral Surg Oral Med Oral Pathol Oral Radiol Endoden
dc.identifier.issn1079-2104-
dc.identifier.pmid12789151-
dc.identifier.doi10.1067/moe.2003.140-
dc.identifier.urihttp://hdl.handle.net/10541/78227-
dc.description.abstractMalignant Triton tumor (MTT) is a malignant peripheral nerve sheath tumor showing rhabdomyoblastic differentiation. It is considered a high-grade neoplasm with poor outcome. This report describes an MTT appearing in the oral cavity. On histologic examination the encapsulated lesion was composed of interlacing fascicles of spindle cells and scattered, large, strap-like pleomorphic cells with abundant eosinophilic cytoplasm. No cross striations were seen. Examination of levels through the tissue showed a total of only 4 normal mitoses and no necrosis. Immunohistochemistry demonstrated diffuse S100 positivity in the spindle cells. The large pleomorphic cells were weakly positive for alpha-sarcomeric actin and myoglobin, although variably but strongly positive for desmin. Management involved a small en bloc resection of the maxilla. After 33 months there was no sign of recurrence or distant metastasis. It was concluded that low-grade variants of MTT occur that do not have an aggressive clinical course.en
dc.language.isoenen
dc.subjectGingival Canceren
dc.subject.meshActins-
dc.subject.meshAdult-
dc.subject.meshCytoplasm-
dc.subject.meshDesmin-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshFemale-
dc.subject.meshGingival Neoplasms-
dc.subject.meshHumans-
dc.subject.meshMitosis-
dc.subject.meshMyoglobin-
dc.subject.meshNeurilemmoma-
dc.subject.meshS100 Proteins-
dc.titleLow-grade malignant Triton tumor of the oral cavity: a case report.en
dc.typeArticleen
dc.contributor.departmentUniversity Dental Hospital of Manchester, Manchester, United Kingdom. jamesj@fsl.den.man.ac.uken
dc.identifier.journalOral surgery, Oral medicine, Oral pathology, Oral radiology, and Endodonticsen

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