Performance of a block detector PET scanner in imaging non-pure positron emitters--modelling and experimental validation with 124I.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78133
Title:
Performance of a block detector PET scanner in imaging non-pure positron emitters--modelling and experimental validation with 124I.
Authors:
Robinson, Stephen P; Julyan, Peter J; Hastings, David L; Zweit, Jamal
Abstract:
The key performance measures of resolution, count rate, sensitivity and scatter fraction are predicted for a dedicated BGO block detector patient PET scanner (GE Advance) in 2D mode for imaging with the non-pure positron-emitting radionuclides 124I, 55Co, 61Cu, 62Cu, 64Cu and 76Br. Model calculations including parameters of the scanner, decay characteristics of the radionuclides and measured parameters in imaging the pure positron-emitter 18F are used to predict performance according to the National Electrical Manufacturers Association (NEMA) NU 2-1994 criteria. Predictions are tested with measurements made using 124I and show that, in comparison with 18F, resolution degrades by 1.2 mm radially and tangentially throughout the field-of-view (prediction: 1.2 mm), count-rate performance reduces considerably and in close accordance with calculations, sensitivity decreases to 23.4% of that with 18F (prediction: 22.9%) and measured scatter fraction increases from 10.0% to 14.5% (prediction: 14.7%). Model predictions are expected to be equally accurate for other radionuclides and may be extended to similar scanners. Although performance is worse with 124I than 18F, imaging is not precluded in 2D mode. The viability of 124I imaging and performance in a clinical context compared with 18F is illustrated with images of a patient with recurrent thyroid cancer acquired using both [124I]-sodium iodide and [18F]-2-fluoro-2-deoxyglucose.
Affiliation:
North Western Medical Physics, Christie Hospital, Manchester, M20 4BX, UK.
Citation:
Performance of a block detector PET scanner in imaging non-pure positron emitters--modelling and experimental validation with 124I. 2004, 49 (24):5505-28 Phys Med Biol
Journal:
Physics in Medicine and Biology
Issue Date:
21-Dec-2004
URI:
http://hdl.handle.net/10541/78133
PubMed ID:
15724539
Type:
Article
Language:
en
ISSN:
0031-9155
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorRobinson, Stephen P-
dc.contributor.authorJulyan, Peter J-
dc.contributor.authorHastings, David L-
dc.contributor.authorZweit, Jamal-
dc.date.accessioned2009-08-21T10:06:10Z-
dc.date.available2009-08-21T10:06:10Z-
dc.date.issued2004-12-21-
dc.identifier.citationPerformance of a block detector PET scanner in imaging non-pure positron emitters--modelling and experimental validation with 124I. 2004, 49 (24):5505-28 Phys Med Biolen
dc.identifier.issn0031-9155-
dc.identifier.pmid15724539-
dc.identifier.urihttp://hdl.handle.net/10541/78133-
dc.description.abstractThe key performance measures of resolution, count rate, sensitivity and scatter fraction are predicted for a dedicated BGO block detector patient PET scanner (GE Advance) in 2D mode for imaging with the non-pure positron-emitting radionuclides 124I, 55Co, 61Cu, 62Cu, 64Cu and 76Br. Model calculations including parameters of the scanner, decay characteristics of the radionuclides and measured parameters in imaging the pure positron-emitter 18F are used to predict performance according to the National Electrical Manufacturers Association (NEMA) NU 2-1994 criteria. Predictions are tested with measurements made using 124I and show that, in comparison with 18F, resolution degrades by 1.2 mm radially and tangentially throughout the field-of-view (prediction: 1.2 mm), count-rate performance reduces considerably and in close accordance with calculations, sensitivity decreases to 23.4% of that with 18F (prediction: 22.9%) and measured scatter fraction increases from 10.0% to 14.5% (prediction: 14.7%). Model predictions are expected to be equally accurate for other radionuclides and may be extended to similar scanners. Although performance is worse with 124I than 18F, imaging is not precluded in 2D mode. The viability of 124I imaging and performance in a clinical context compared with 18F is illustrated with images of a patient with recurrent thyroid cancer acquired using both [124I]-sodium iodide and [18F]-2-fluoro-2-deoxyglucose.en
dc.language.isoenen
dc.subject.meshComputer Simulation-
dc.subject.meshEquipment Design-
dc.subject.meshEquipment Failure Analysis-
dc.subject.meshImage Enhancement-
dc.subject.meshImage Interpretation, Computer-Assisted-
dc.subject.meshIodine Radioisotopes-
dc.subject.meshModels, Biological-
dc.subject.meshPhantoms, Imaging-
dc.subject.meshPositron-Emission Tomography-
dc.subject.meshRadiation Dosage-
dc.subject.meshRadiometry-
dc.subject.meshRadiopharmaceuticals-
dc.subject.meshReproducibility of Results-
dc.subject.meshSensitivity and Specificity-
dc.subject.meshTransducers-
dc.titlePerformance of a block detector PET scanner in imaging non-pure positron emitters--modelling and experimental validation with 124I.en
dc.typeArticleen
dc.contributor.departmentNorth Western Medical Physics, Christie Hospital, Manchester, M20 4BX, UK.en
dc.identifier.journalPhysics in Medicine and Biologyen

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