Post-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: a report of three cases of T-anaplastic large-cell lymphoma with cutaneous presentation and a review of the literature.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78129
Title:
Post-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: a report of three cases of T-anaplastic large-cell lymphoma with cutaneous presentation and a review of the literature.
Authors:
Coyne, John; Banerjee, Saumitra S; Bromley, Michael; Mills, S; Diss, T C; Harris, Martin
Abstract:
AIMS: To report the clinical, pathological and immunohistochemical features of three cases of post-transplant T-cell lymphoproliferative disorder (T-PTLD) T-cell lymphoma with primary cutaneous presentation. METHODS AND RESULTS: Three cases of primary cutaneous post-transplantation anaplastic large-cell lymphomas occurred in renal transplant recipients and were shown to display a T-cell immunophenotype; all were ALK 1 protein and EMA negative and two were Epstein-Barr virus positive using in-situ hybridization. Two displayed a CD4+ phenotype, two were focally CD56+ and all three were negative for the cytolytic enzyme granzyme B. In two cases monoclonality was established by T-cell receptor gene rearrangement study. All presented with nodular cutaneous involvement and all were ultimately fatal. CONCLUSION: T-PTLDs are uncommon histological subtypes both in a general context and associated with cutaneous presentation. Our findings suggest clinicopathological and immunophenotypic similarities to primary cutaneous anaplastic large-cell lymphoma but with a progressive clinical behaviour similar to previously reported T-PTLD and to systemic nodal ALK- anaplastic large-cell lymphoma.
Affiliation:
Department of Histopathology, Withenshawe Hospital, Manchester, UK.
Citation:
Post-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: a report of three cases of T-anaplastic large-cell lymphoma with cutaneous presentation and a review of the literature. 2004, 44 (4):387-93 Histopathology
Journal:
Histopathology
Issue Date:
Apr-2004
URI:
http://hdl.handle.net/10541/78129
DOI:
10.1111/j.1365-2559.2004.01847.x
PubMed ID:
15049906
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorCoyne, John-
dc.contributor.authorBanerjee, Saumitra S-
dc.contributor.authorBromley, Michael-
dc.contributor.authorMills, S-
dc.contributor.authorDiss, T C-
dc.contributor.authorHarris, Martin-
dc.date.accessioned2009-08-21T10:01:45Z-
dc.date.available2009-08-21T10:01:45Z-
dc.date.issued2004-04-
dc.identifier.citationPost-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: a report of three cases of T-anaplastic large-cell lymphoma with cutaneous presentation and a review of the literature. 2004, 44 (4):387-93 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid15049906-
dc.identifier.doi10.1111/j.1365-2559.2004.01847.x-
dc.identifier.urihttp://hdl.handle.net/10541/78129-
dc.description.abstractAIMS: To report the clinical, pathological and immunohistochemical features of three cases of post-transplant T-cell lymphoproliferative disorder (T-PTLD) T-cell lymphoma with primary cutaneous presentation. METHODS AND RESULTS: Three cases of primary cutaneous post-transplantation anaplastic large-cell lymphomas occurred in renal transplant recipients and were shown to display a T-cell immunophenotype; all were ALK 1 protein and EMA negative and two were Epstein-Barr virus positive using in-situ hybridization. Two displayed a CD4+ phenotype, two were focally CD56+ and all three were negative for the cytolytic enzyme granzyme B. In two cases monoclonality was established by T-cell receptor gene rearrangement study. All presented with nodular cutaneous involvement and all were ultimately fatal. CONCLUSION: T-PTLDs are uncommon histological subtypes both in a general context and associated with cutaneous presentation. Our findings suggest clinicopathological and immunophenotypic similarities to primary cutaneous anaplastic large-cell lymphoma but with a progressive clinical behaviour similar to previously reported T-PTLD and to systemic nodal ALK- anaplastic large-cell lymphoma.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshIn Situ Hybridization-
dc.subject.meshKidney Transplantation-
dc.subject.meshLupus Erythematosus, Systemic-
dc.subject.meshLymphoma, Large B-Cell, Diffuse-
dc.subject.meshLymphoma, T-Cell-
dc.subject.meshLymphoproliferative Disorders-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshSkin Diseases-
dc.titlePost-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: a report of three cases of T-anaplastic large-cell lymphoma with cutaneous presentation and a review of the literature.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Withenshawe Hospital, Manchester, UK.en
dc.identifier.journalHistopathologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.