Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78125
Title:
Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study.
Authors:
Jenkins, Valerie A; Shilling, Valerie; Fallowfield, Lesley J; Howell, Anthony ( 0000-0002-3879-5991 ) ; Hutton, Sam
Abstract:
This pilot study examines whether hormone therapy for breast cancer affects cognition. Patients participating in a randomised trial of anastrozole, tamoxifen alone or combined (ATAC) (n=94) and a group of women without breast cancer (n=35) completed a battery of neuropsychological measures. Compared with the control group, the patients were impaired on a processing speed task (p=0.032) and on a measure of immediate verbal memory (p=0.026) after controlling for the use of hormone replacement therapy in both groups. Patient group performance was not significantly related to length of treatment or measures of psychological morbidity. The results showed specific impairments in processing speed and verbal memory in women receiving hormonal therapy for the treatment of breast cancer. Verbal memory may be especially sensitive to changes in oestrogen levels, a finding commonly reported in studies of hormone replacement therapy in healthy women. In view of the increased use of hormone therapies in an adjuvant and preventative setting their impact on cognitive functioning should be investigated more thoroughly.
Affiliation:
Cancer Research UK, Brighton and Sussex Medical School, University of Sussex, Brighton, UK. v.jenkins@biols.susx.ac.uk
Citation:
Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study. 2004, 13 (1):61-6 Psychooncology
Journal:
Psycho-Oncology
Issue Date:
Jan-2004
URI:
http://hdl.handle.net/10541/78125
DOI:
10.1002/pon.709
PubMed ID:
14745746
Type:
Article
Language:
en
ISSN:
1057-9249
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJenkins, Valerie A-
dc.contributor.authorShilling, Valerie-
dc.contributor.authorFallowfield, Lesley J-
dc.contributor.authorHowell, Anthony-
dc.contributor.authorHutton, Sam-
dc.date.accessioned2009-08-21T09:39:26Z-
dc.date.available2009-08-21T09:39:26Z-
dc.date.issued2004-01-
dc.identifier.citationDoes hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study. 2004, 13 (1):61-6 Psychooncologyen
dc.identifier.issn1057-9249-
dc.identifier.pmid14745746-
dc.identifier.doi10.1002/pon.709-
dc.identifier.urihttp://hdl.handle.net/10541/78125-
dc.description.abstractThis pilot study examines whether hormone therapy for breast cancer affects cognition. Patients participating in a randomised trial of anastrozole, tamoxifen alone or combined (ATAC) (n=94) and a group of women without breast cancer (n=35) completed a battery of neuropsychological measures. Compared with the control group, the patients were impaired on a processing speed task (p=0.032) and on a measure of immediate verbal memory (p=0.026) after controlling for the use of hormone replacement therapy in both groups. Patient group performance was not significantly related to length of treatment or measures of psychological morbidity. The results showed specific impairments in processing speed and verbal memory in women receiving hormonal therapy for the treatment of breast cancer. Verbal memory may be especially sensitive to changes in oestrogen levels, a finding commonly reported in studies of hormone replacement therapy in healthy women. In view of the increased use of hormone therapies in an adjuvant and preventative setting their impact on cognitive functioning should be investigated more thoroughly.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectOestrogensen
dc.subject.meshAffect-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshAnxiety-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCognition Disorders-
dc.subject.meshDepression-
dc.subject.meshEngland-
dc.subject.meshEstrogens-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMemory Disorders-
dc.subject.meshMemory, Short-Term-
dc.subject.meshMiddle Aged-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshNitriles-
dc.subject.meshPersonality Inventory-
dc.subject.meshPilot Projects-
dc.subject.meshReaction Time-
dc.subject.meshSelf Assessment (Psychology)-
dc.subject.meshTamoxifen-
dc.subject.meshTriazoles-
dc.subject.meshVerbal Learning-
dc.titleDoes hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK, Brighton and Sussex Medical School, University of Sussex, Brighton, UK. v.jenkins@biols.susx.ac.uken
dc.identifier.journalPsycho-Oncologyen

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