2.50
Hdl Handle:
http://hdl.handle.net/10541/78107
Title:
Steroid receptors in human breast cancer.
Authors:
Clarke, Robert B; Anderson, Elizabeth; Howell, Anthony ( 0000-0002-3879-5991 )
Abstract:
Ovarian steroids, acting through nuclear receptors, are crucial players in normal breast development and cancer. Estrogen, in particular, is the focus of breast cancer therapies because tumours are often dependent on this steroid for growth. Recently, novel genes and/or protein isoforms of receptors for both estrogen and progesterone have been discovered, leading us to reappraise their roles in breast development and cancer. Recognition of changes in estrogen receptor biology that occur in the transition from normal development to cancer has emphasized its contribution to tumorigenesis. In addition, complex interactions with other signalling pathways, particularly growth factor pathways, have recently come to the forefront. These interactions might explain resistance to endocrine treatments and offer solutions in terms of novel therapeutic targets.
Affiliation:
CR-UK Department of Medical Oncology, Christie Hospital, Manchester, UK. rclarke@picr.man.ac.uk
Citation:
Steroid receptors in human breast cancer. 2004, 15 (7):316-23 Trends Endocrinol. Metab.
Journal:
Trends in Endocrinology and Metabolism
Issue Date:
Sep-2004
URI:
http://hdl.handle.net/10541/78107
DOI:
10.1016/j.tem.2004.07.004
PubMed ID:
15350603
Type:
Article
Language:
en
ISSN:
1043-2760
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorClarke, Robert B-
dc.contributor.authorAnderson, Elizabeth-
dc.contributor.authorHowell, Anthony-
dc.date.accessioned2009-08-21T09:53:09Z-
dc.date.available2009-08-21T09:53:09Z-
dc.date.issued2004-09-
dc.identifier.citationSteroid receptors in human breast cancer. 2004, 15 (7):316-23 Trends Endocrinol. Metab.en
dc.identifier.issn1043-2760-
dc.identifier.pmid15350603-
dc.identifier.doi10.1016/j.tem.2004.07.004-
dc.identifier.urihttp://hdl.handle.net/10541/78107-
dc.description.abstractOvarian steroids, acting through nuclear receptors, are crucial players in normal breast development and cancer. Estrogen, in particular, is the focus of breast cancer therapies because tumours are often dependent on this steroid for growth. Recently, novel genes and/or protein isoforms of receptors for both estrogen and progesterone have been discovered, leading us to reappraise their roles in breast development and cancer. Recognition of changes in estrogen receptor biology that occur in the transition from normal development to cancer has emphasized its contribution to tumorigenesis. In addition, complex interactions with other signalling pathways, particularly growth factor pathways, have recently come to the forefront. These interactions might explain resistance to endocrine treatments and offer solutions in terms of novel therapeutic targets.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshBreast Neoplasms-
dc.subject.meshCues-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshOvary-
dc.subject.meshReceptors, Steroid-
dc.titleSteroid receptors in human breast cancer.en
dc.typeArticleen
dc.contributor.departmentCR-UK Department of Medical Oncology, Christie Hospital, Manchester, UK. rclarke@picr.man.ac.uken
dc.identifier.journalTrends in Endocrinology and Metabolismen
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