Autotransplantation of ovarian tissue and the risk of disease transmission.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78095
Title:
Autotransplantation of ovarian tissue and the risk of disease transmission.
Authors:
Radford, John A ( 0000-0001-7898-2786 )
Abstract:
Temporary ovarian function has been reported following reimplantation of frozen/thawed cortical tissue and it is hoped that in time this technique will allow women sterilised by treatment for cancer to regain their fertility. There is however a concern, supported by animal data, that ovarian tissue may be contaminated by disease capable of causing a relapse after transplantation. One experiment, in which ovarian tissue from women with lymphoma was xenografted into immunodeficient mice, showed no evidence of transmission but these results require confirmation and no data exists for other malignancies. For the time being, therefore, it is recommended that harvesting and reimplantation of ovarian tissue should only take place within the confines of carefully designed clinical trials.
Affiliation:
Cancer Research UK Department of Medical Oncology, Christie Hospital, Manchester M20 4BX, UK. john.radford@man.ac.uk
Citation:
Autotransplantation of ovarian tissue and the risk of disease transmission. 2004, 113 Suppl 1:S48-9 Eur. J. Obstet. Gynecol. Reprod. Biol.
Journal:
European Journal of Obstetrics, Gynecology, and Reproductive Biology
Issue Date:
5-Apr-2004
URI:
http://hdl.handle.net/10541/78095
DOI:
10.1016/j.ejogrb.2003.11.011
PubMed ID:
15041131
Type:
Article
Language:
en
ISSN:
0301-2115
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRadford, John A-
dc.date.accessioned2009-08-21T08:50:06Z-
dc.date.available2009-08-21T08:50:06Z-
dc.date.issued2004-04-05-
dc.identifier.citationAutotransplantation of ovarian tissue and the risk of disease transmission. 2004, 113 Suppl 1:S48-9 Eur. J. Obstet. Gynecol. Reprod. Biol.en
dc.identifier.issn0301-2115-
dc.identifier.pmid15041131-
dc.identifier.doi10.1016/j.ejogrb.2003.11.011-
dc.identifier.urihttp://hdl.handle.net/10541/78095-
dc.description.abstractTemporary ovarian function has been reported following reimplantation of frozen/thawed cortical tissue and it is hoped that in time this technique will allow women sterilised by treatment for cancer to regain their fertility. There is however a concern, supported by animal data, that ovarian tissue may be contaminated by disease capable of causing a relapse after transplantation. One experiment, in which ovarian tissue from women with lymphoma was xenografted into immunodeficient mice, showed no evidence of transmission but these results require confirmation and no data exists for other malignancies. For the time being, therefore, it is recommended that harvesting and reimplantation of ovarian tissue should only take place within the confines of carefully designed clinical trials.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshFemale-
dc.subject.meshFertility-
dc.subject.meshHumans-
dc.subject.meshInfertility, Female-
dc.subject.meshLymphoma-
dc.subject.meshMice-
dc.subject.meshOvary-
dc.subject.meshTransplantation, Autologous-
dc.subject.meshTransplantation, Heterologous-
dc.titleAutotransplantation of ovarian tissue and the risk of disease transmission.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Department of Medical Oncology, Christie Hospital, Manchester M20 4BX, UK. john.radford@man.ac.uken
dc.identifier.journalEuropean Journal of Obstetrics, Gynecology, and Reproductive Biologyen

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