2.50
Hdl Handle:
http://hdl.handle.net/10541/78033
Title:
BRCA1/2 predictive testing: a study of uptake in two centres.
Authors:
Brooks, Lucy; Lennard, Fiona; Shenton, Andrew; Lalloo, Fiona; Ambus, Ingrid; Ardern-Jones, Audrey; Belk, Rachel; Kerr, Bronwyn; Craufurd, David; Eeles, Rosalind; Evans, D Gareth R
Abstract:
Differences in reported uptake of genetic testing for mutations in BRCA1 and BRCA2 can largely be accounted for by different methodologies and by studying research vs nonresearch families. In our joint study of 75 nonresearch families from two UK centres in which at least 3 years had elapsed since the initial proband had been informed of the availability of testing, only 45 and 34% of eligible individuals from Manchester and London, respectively, had come forward for counselling. Final uptake rates using a non-proactive approach were 53 and 29% for women and 11-12% for men, but the figure among those attending clinic was 73 and 62%, respectively. Unlike previous studies, we did not find that uptake had stabilised after a year with 25% of those being tested more than 2 years after the family was informed, and several delaying a considerable time between genetics appointments. We believe that the particularly low uptake even of counselling in men may need to be addressed by improving family communication or providing information sheets for family members to disseminate.
Affiliation:
Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Manchester M13 0JH, UK.
Citation:
BRCA1/2 predictive testing: a study of uptake in two centres. 2004, 12 (8):654-62 Eur. J. Hum. Genet.
Journal:
European Journal of Human Genetics
Issue Date:
Aug-2004
URI:
http://hdl.handle.net/10541/78033
DOI:
10.1038/sj.ejhg.5201206
PubMed ID:
15138457
Type:
Article
Language:
en
ISSN:
1018-4813
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBrooks, Lucy-
dc.contributor.authorLennard, Fiona-
dc.contributor.authorShenton, Andrew-
dc.contributor.authorLalloo, Fiona-
dc.contributor.authorAmbus, Ingrid-
dc.contributor.authorArdern-Jones, Audrey-
dc.contributor.authorBelk, Rachel-
dc.contributor.authorKerr, Bronwyn-
dc.contributor.authorCraufurd, David-
dc.contributor.authorEeles, Rosalind-
dc.contributor.authorEvans, D Gareth R-
dc.date.accessioned2009-08-20T12:57:40Z-
dc.date.available2009-08-20T12:57:40Z-
dc.date.issued2004-08-
dc.identifier.citationBRCA1/2 predictive testing: a study of uptake in two centres. 2004, 12 (8):654-62 Eur. J. Hum. Genet.en
dc.identifier.issn1018-4813-
dc.identifier.pmid15138457-
dc.identifier.doi10.1038/sj.ejhg.5201206-
dc.identifier.urihttp://hdl.handle.net/10541/78033-
dc.description.abstractDifferences in reported uptake of genetic testing for mutations in BRCA1 and BRCA2 can largely be accounted for by different methodologies and by studying research vs nonresearch families. In our joint study of 75 nonresearch families from two UK centres in which at least 3 years had elapsed since the initial proband had been informed of the availability of testing, only 45 and 34% of eligible individuals from Manchester and London, respectively, had come forward for counselling. Final uptake rates using a non-proactive approach were 53 and 29% for women and 11-12% for men, but the figure among those attending clinic was 73 and 62%, respectively. Unlike previous studies, we did not find that uptake had stabilised after a year with 25% of those being tested more than 2 years after the family was informed, and several delaying a considerable time between genetics appointments. We believe that the particularly low uptake even of counselling in men may need to be addressed by improving family communication or providing information sheets for family members to disseminate.en
dc.language.isoenen
dc.subject.meshFemale-
dc.subject.meshGenes, BRCA1-
dc.subject.meshGenes, BRCA2-
dc.subject.meshGenetic Counseling-
dc.subject.meshGenetic Screening-
dc.subject.meshGreat Britain-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMutation-
dc.subject.meshPedigree-
dc.subject.meshTime Factors-
dc.titleBRCA1/2 predictive testing: a study of uptake in two centres.en
dc.typeArticleen
dc.contributor.departmentAcademic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Manchester M13 0JH, UK.en
dc.identifier.journalEuropean Journal of Human Geneticsen

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