Positron emission tomography imaging of cell proliferation in oncology.

2.50
Hdl Handle:
http://hdl.handle.net/10541/78004
Title:
Positron emission tomography imaging of cell proliferation in oncology.
Authors:
Kenny, L M; Aboagye, E O; Price, Patricia M
Abstract:
Tumour-cell proliferation is a hallmark of the malignant phenotype. Positron emission tomography (PET) offers a unique method of imaging biological and biochemical changes in vivo. Radiolabelled thymidine and thymidine analogues are currently in development as PET tracers. By studying the uptake and kinetics of such compounds using PET, a measure of DNA synthesis and hence cell proliferation can be obtained. Molecular imaging of cellular proliferation with PET is now possible, and has the potential to play an important role in the evaluation of efficacy of new anti-cancer agents.
Affiliation:
Molecular Therapy Group and PET Oncology Group, Hammersmith Hospital, London, UK.
Citation:
Positron emission tomography imaging of cell proliferation in oncology. 2004, 16 (3):176-85 Clin Oncol
Journal:
Clinical Oncology
Issue Date:
May-2004
URI:
http://hdl.handle.net/10541/78004
PubMed ID:
15191004
Type:
Article
Language:
en
ISSN:
0936-6555
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKenny, L M-
dc.contributor.authorAboagye, E O-
dc.contributor.authorPrice, Patricia M-
dc.date.accessioned2009-08-20T11:41:50Z-
dc.date.available2009-08-20T11:41:50Z-
dc.date.issued2004-05-
dc.identifier.citationPositron emission tomography imaging of cell proliferation in oncology. 2004, 16 (3):176-85 Clin Oncolen
dc.identifier.issn0936-6555-
dc.identifier.pmid15191004-
dc.identifier.urihttp://hdl.handle.net/10541/78004-
dc.description.abstractTumour-cell proliferation is a hallmark of the malignant phenotype. Positron emission tomography (PET) offers a unique method of imaging biological and biochemical changes in vivo. Radiolabelled thymidine and thymidine analogues are currently in development as PET tracers. By studying the uptake and kinetics of such compounds using PET, a measure of DNA synthesis and hence cell proliferation can be obtained. Molecular imaging of cellular proliferation with PET is now possible, and has the potential to play an important role in the evaluation of efficacy of new anti-cancer agents.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAntiviral Agents-
dc.subject.meshCell Cycle-
dc.subject.meshCyclins-
dc.subject.meshDNA-
dc.subject.meshDideoxynucleosides-
dc.subject.meshHumans-
dc.subject.meshKinetics-
dc.subject.meshNeoplasms-
dc.subject.meshPhenotype-
dc.subject.meshThymidine-
dc.subject.meshTomography, Emission-Computed-
dc.titlePositron emission tomography imaging of cell proliferation in oncology.en
dc.typeArticleen
dc.contributor.departmentMolecular Therapy Group and PET Oncology Group, Hammersmith Hospital, London, UK.en
dc.identifier.journalClinical Oncologyen

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