2.50
Hdl Handle:
http://hdl.handle.net/10541/77980
Title:
Pitfalls in the diagnosis of acromegaly.
Authors:
Pokrajac, Ana; Trainer, Peter J
Abstract:
Acromegaly is a disfiguring and disabling illness which, when inadequately treated, reduces life expectancy. An implication of the ability to offer effective treatment is the increased onus on physicians of all sorts to ensure acromegaly is diagnosed and treated as early as possible. To this end, criteria for the diagnosis of acromegaly have been proposed in the consensus statement of Giustina et al. However, other data suggest that the proposed criteria are not rigorous enough and strict adherence to the guidelines would result in failure to diagnose a significant number of patients. A review of published experience suggests that the combination of a GH nadir during an oral glucose tolerance test of <0.25 microg/l plus a normal age-related insulin growth factor-I level makes the diagnosis of acromegaly extremely unlikely.
Affiliation:
Department of Endocrinology, Christie Hospital, Manchester, UK.
Citation:
Pitfalls in the diagnosis of acromegaly. 2004, 62 Suppl 3:74-8 Horm. Res.
Journal:
Hormone Research
Issue Date:
2004
URI:
http://hdl.handle.net/10541/77980
DOI:
10.1159/000080504
PubMed ID:
15539804
Type:
Article
Language:
en
ISSN:
0301-0163
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPokrajac, Ana-
dc.contributor.authorTrainer, Peter J-
dc.date.accessioned2009-08-20T10:19:00Z-
dc.date.available2009-08-20T10:19:00Z-
dc.date.issued2004-
dc.identifier.citationPitfalls in the diagnosis of acromegaly. 2004, 62 Suppl 3:74-8 Horm. Res.en
dc.identifier.issn0301-0163-
dc.identifier.pmid15539804-
dc.identifier.doi10.1159/000080504-
dc.identifier.urihttp://hdl.handle.net/10541/77980-
dc.description.abstractAcromegaly is a disfiguring and disabling illness which, when inadequately treated, reduces life expectancy. An implication of the ability to offer effective treatment is the increased onus on physicians of all sorts to ensure acromegaly is diagnosed and treated as early as possible. To this end, criteria for the diagnosis of acromegaly have been proposed in the consensus statement of Giustina et al. However, other data suggest that the proposed criteria are not rigorous enough and strict adherence to the guidelines would result in failure to diagnose a significant number of patients. A review of published experience suggests that the combination of a GH nadir during an oral glucose tolerance test of <0.25 microg/l plus a normal age-related insulin growth factor-I level makes the diagnosis of acromegaly extremely unlikely.en
dc.language.isoenen
dc.subject.meshAcromegaly-
dc.subject.meshAging-
dc.subject.meshGlucose Tolerance Test-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshInsulin-Like Growth Factor I-
dc.titlePitfalls in the diagnosis of acromegaly.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester, UK.en
dc.identifier.journalHormone Researchen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.