2.50
Hdl Handle:
http://hdl.handle.net/10541/77929
Title:
The insulin-like growth factor I generation test in adults.
Authors:
Lissett, Catherine A; Gleeson, Helena K; Shalet, Stephen M
Abstract:
The insulin-like growth factor I (IGF-I) generation test has the potential to assess the ability of an individual to respond to an acute bolus of growth hormone (GH), in terms of IGF-I, IGF-binding protein 3 and acid-labile subunit responses. This article will discuss something of the history of the IGF-I generation test, and review some of the major studies to date. The IGF-I generation test was first used in adults by Lieberman et al., who studied the effects of ageing and oestrogen administration, and suggested that decreased responsiveness to GH occurs with increasing age and oral oestrogen administration. Our results, however, show that, while activity of the GH/IGF-I axis declines with age, peripheral responsiveness to GH is not affected. As in the Lieberman study, we found that oral oestrogen replacement reduces responses of GH-dependent peptides to GH stimulation in healthy post-menopausal women. Transdermal oestrogen administration also reduced responsiveness to GH, although to a lesser degree than orally administered oestrogen. In addition, utilizing a non-weight-based dose of GH we have demonstrated that obese individuals produce greater increases in IGF-I following an acute bolus of GH. In GH deficiency (GHD), data suggesting enhanced peripheral responsiveness should be interpreted with caution, and with awareness of differences between these groups in terms of age and obesity. The IGF-I generation test may allow a fresh approach to unanswered questions in the field of GHD, but as the IGF-I response to GH is not strictly associated with protein anabolism or clinical benefit, the question remains whether this test will predict the effect of longer-term GH administration.
Affiliation:
Department of Endocrinology, Christie Hospital, Manchester, UK. Klissett@aol.com
Citation:
The insulin-like growth factor I generation test in adults. 2004, 62 Suppl 1:44-9 Horm. Res.
Journal:
Hormone Research
Issue Date:
2004
URI:
http://hdl.handle.net/10541/77929
DOI:
10.1159/000080758
PubMed ID:
15761232
Type:
Article
Language:
en
ISSN:
0301-0163
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLissett, Catherine A-
dc.contributor.authorGleeson, Helena K-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-08-19T16:19:37Z-
dc.date.available2009-08-19T16:19:37Z-
dc.date.issued2004-
dc.identifier.citationThe insulin-like growth factor I generation test in adults. 2004, 62 Suppl 1:44-9 Horm. Res.en
dc.identifier.issn0301-0163-
dc.identifier.pmid15761232-
dc.identifier.doi10.1159/000080758-
dc.identifier.urihttp://hdl.handle.net/10541/77929-
dc.description.abstractThe insulin-like growth factor I (IGF-I) generation test has the potential to assess the ability of an individual to respond to an acute bolus of growth hormone (GH), in terms of IGF-I, IGF-binding protein 3 and acid-labile subunit responses. This article will discuss something of the history of the IGF-I generation test, and review some of the major studies to date. The IGF-I generation test was first used in adults by Lieberman et al., who studied the effects of ageing and oestrogen administration, and suggested that decreased responsiveness to GH occurs with increasing age and oral oestrogen administration. Our results, however, show that, while activity of the GH/IGF-I axis declines with age, peripheral responsiveness to GH is not affected. As in the Lieberman study, we found that oral oestrogen replacement reduces responses of GH-dependent peptides to GH stimulation in healthy post-menopausal women. Transdermal oestrogen administration also reduced responsiveness to GH, although to a lesser degree than orally administered oestrogen. In addition, utilizing a non-weight-based dose of GH we have demonstrated that obese individuals produce greater increases in IGF-I following an acute bolus of GH. In GH deficiency (GHD), data suggesting enhanced peripheral responsiveness should be interpreted with caution, and with awareness of differences between these groups in terms of age and obesity. The IGF-I generation test may allow a fresh approach to unanswered questions in the field of GHD, but as the IGF-I response to GH is not strictly associated with protein anabolism or clinical benefit, the question remains whether this test will predict the effect of longer-term GH administration.en
dc.language.isoenen
dc.subjectOestrogensen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAging-
dc.subject.meshEstrogens-
dc.subject.meshFemale-
dc.subject.meshGrowth Hormone-
dc.subject.meshHumans-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshObesity-
dc.subject.meshSensitivity and Specificity-
dc.titleThe insulin-like growth factor I generation test in adults.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester, UK. Klissett@aol.comen
dc.identifier.journalHormone Researchen
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