The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours.

2.50
Hdl Handle:
http://hdl.handle.net/10541/77927
Title:
The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours.
Authors:
Gleeson, Helena K; Shalet, Stephen M
Abstract:
Survival rates are improving following cancer therapy for childhood brain tumours. There is therefore a growing cohort of survivors at risk of late effects of cancer therapy. Endocrine problems are very common in these patients. The recognition and prompt management of these are essential to prevent further morbidity and impairment of quality of life. Cranial radiation can damage hypothalamic-pituitary function, most frequently affecting GH status; however, higher radiation doses may cause more widespread hypothalamic-pituitary damage. Early puberty secondary to cranial irradiation is now being managed with gonadotrophin-releasing hormone analogues to improve final height. Prompt diagnosis and management of GH deficiency may improve final height outcome; continued GH therapy beyond final height aids the achievement of adult body composition (lean body mass and bone mass) and GH therapy in adulthood improves quality of life. Both cranial irradiation alone and with spinal irradiation can result in radiation damage to the thyroid resulting in hypothyroidism and thyroid nodules, a high proportion of which are malignant. Gonadal damage secondary to spinal irradiation and adjuvant chemotherapy may have long-term consequences including infertility.
Affiliation:
Department of Endocrinology, Christie Hospital, Manchester M20 4BX, UK. Helena.Gleeson@christie-tr.nwest.nhs.uk
Citation:
The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. 2004, 11 (4):589-602 Endocr. Relat. Cancer
Journal:
Endocrine-Related Cancer
Issue Date:
Dec-2004
URI:
http://hdl.handle.net/10541/77927
DOI:
10.1677/erc.1.00779
PubMed ID:
15613441
Type:
Article
Language:
en
ISSN:
1351-0088
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGleeson, Helena K-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-08-19T16:17:16Z-
dc.date.available2009-08-19T16:17:16Z-
dc.date.issued2004-12-
dc.identifier.citationThe impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. 2004, 11 (4):589-602 Endocr. Relat. Canceren
dc.identifier.issn1351-0088-
dc.identifier.pmid15613441-
dc.identifier.doi10.1677/erc.1.00779-
dc.identifier.urihttp://hdl.handle.net/10541/77927-
dc.description.abstractSurvival rates are improving following cancer therapy for childhood brain tumours. There is therefore a growing cohort of survivors at risk of late effects of cancer therapy. Endocrine problems are very common in these patients. The recognition and prompt management of these are essential to prevent further morbidity and impairment of quality of life. Cranial radiation can damage hypothalamic-pituitary function, most frequently affecting GH status; however, higher radiation doses may cause more widespread hypothalamic-pituitary damage. Early puberty secondary to cranial irradiation is now being managed with gonadotrophin-releasing hormone analogues to improve final height. Prompt diagnosis and management of GH deficiency may improve final height outcome; continued GH therapy beyond final height aids the achievement of adult body composition (lean body mass and bone mass) and GH therapy in adulthood improves quality of life. Both cranial irradiation alone and with spinal irradiation can result in radiation damage to the thyroid resulting in hypothyroidism and thyroid nodules, a high proportion of which are malignant. Gonadal damage secondary to spinal irradiation and adjuvant chemotherapy may have long-term consequences including infertility.en
dc.language.isoenen
dc.subjectBrain Canceren
dc.subject.meshAdult-
dc.subject.meshBrain Neoplasms-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshChild-
dc.subject.meshChild Development-
dc.subject.meshChild, Preschool-
dc.subject.meshGonads-
dc.subject.meshHormones-
dc.subject.meshHumans-
dc.subject.meshHypothalamo-Hypophyseal System-
dc.subject.meshInfant-
dc.subject.meshObesity-
dc.subject.meshPituitary-Adrenal System-
dc.subject.meshPuberty, Precocious-
dc.subject.meshRisk Factors-
dc.subject.meshSurvivors-
dc.subject.meshThyroid Gland-
dc.titleThe impact of cancer therapy on the endocrine system in survivors of childhood brain tumours.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester M20 4BX, UK. Helena.Gleeson@christie-tr.nwest.nhs.uken
dc.identifier.journalEndocrine-Related Canceren

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.