The effect of cigarette smoking use and cessation on serum insulin-like growth factors.

2.50
Hdl Handle:
http://hdl.handle.net/10541/77874
Title:
The effect of cigarette smoking use and cessation on serum insulin-like growth factors.
Authors:
Renehan, Andrew G; Atkin, W S; O'Dwyer, Sarah T; Shalet, Stephen M
Abstract:
The patterns of risk association between circulating levels of insulin-like growth factor (IGF)-I, and its main binding protein, IGFBP-3, differ between smoking and nonsmoking-related cancers. To investigate this observation further, we measured serum IGF-I, IGF-II and IGF-binding protein-3 concentrations in 232 men and 210 women (aged 55-64 years), and related peptide levels to smoking characteristics. Current smoking was associated with significant reductions in mean IGFBP-3 levels in men assessed by the number of cigarettes smoked daily (P(trend)=0.007) and pack-years smoked (P(trend)=0.03). Mean IGF-I levels decreased with increasing cigarette use in men (P(trend)=0.11). There were no patterns of association between smoking and IGF peptides in women. For male former vs never smokers, there were no differences in mean IGF-I and IGFBP-3 concentrations, suggesting that smoking cessation is associated with normalisation of peptide concentrations.
Affiliation:
Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. arenehan@picr.man.ac.uk
Citation:
The effect of cigarette smoking use and cessation on serum insulin-like growth factors. 2004, 91 (8):1525-31 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
18-Oct-2004
URI:
http://hdl.handle.net/10541/77874
DOI:
10.1038/sj.bjc.6602150
PubMed ID:
15354219
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRenehan, Andrew G-
dc.contributor.authorAtkin, W S-
dc.contributor.authorO'Dwyer, Sarah T-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-08-19T13:06:27Z-
dc.date.available2009-08-19T13:06:27Z-
dc.date.issued2004-10-18-
dc.identifier.citationThe effect of cigarette smoking use and cessation on serum insulin-like growth factors. 2004, 91 (8):1525-31 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid15354219-
dc.identifier.doi10.1038/sj.bjc.6602150-
dc.identifier.urihttp://hdl.handle.net/10541/77874-
dc.description.abstractThe patterns of risk association between circulating levels of insulin-like growth factor (IGF)-I, and its main binding protein, IGFBP-3, differ between smoking and nonsmoking-related cancers. To investigate this observation further, we measured serum IGF-I, IGF-II and IGF-binding protein-3 concentrations in 232 men and 210 women (aged 55-64 years), and related peptide levels to smoking characteristics. Current smoking was associated with significant reductions in mean IGFBP-3 levels in men assessed by the number of cigarettes smoked daily (P(trend)=0.007) and pack-years smoked (P(trend)=0.03). Mean IGF-I levels decreased with increasing cigarette use in men (P(trend)=0.11). There were no patterns of association between smoking and IGF peptides in women. For male former vs never smokers, there were no differences in mean IGF-I and IGFBP-3 concentrations, suggesting that smoking cessation is associated with normalisation of peptide concentrations.en
dc.language.isoenen
dc.subject.meshCross-Sectional Studies-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshInsulin-Like Growth Factor II-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshRisk Factors-
dc.subject.meshSmoking-
dc.subject.meshSmoking Cessation-
dc.titleThe effect of cigarette smoking use and cessation on serum insulin-like growth factors.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. arenehan@picr.man.ac.uken
dc.identifier.journalBritish Journal of Canceren

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