A comparison of PET imaging characteristics of various copper radioisotopes.

2.50
Hdl Handle:
http://hdl.handle.net/10541/76828
Title:
A comparison of PET imaging characteristics of various copper radioisotopes.
Authors:
Williams, Heather; Robinson, Simon; Julyan, Peter J; Zweit, Jamal; Hastings, David L
Abstract:
PURPOSE: PET radiotracers which incorporate longer-lived radionuclides enable biological processes to be studied over many hours, at centres remote from a cyclotron. This paper examines the radioisotope characteristics, imaging performance, radiation dosimetry and production modes of the four copper radioisotopes, ( 60)Cu,( 61)Cu,( 62)Cu and( 64)Cu, to assess their merits for different PET imaging applications. METHODS: Spatial resolution, sensitivity, scatter fraction and noise-equivalent count rate (NEC) are predicted for( 60)Cu,( 61)Cu,( 62)Cu and( 64)Cu using a model incorporating radionuclide decay properties and scanner parameters for the GE Advance scanner. Dosimetry for( 60)Cu,( 61)Cu and( 64)Cu is performed using the MIRD model and published biodistribution data for copper(II) pyruvaldehyde bis(N(4)-methyl)thiosemicarbazone (Cu-PTSM). RESULTS: (60)Cu and( 62)Cu are characterised by shorter half-lives and higher sensitivity and NEC, making them more suitable for studying the faster kinetics of small molecules, such as Cu-PTSM.( 61)Cu and( 64)Cu have longer half-lives, enabling studies of the slower kinetics of cells and peptides and prolonged imaging to compensate for lower sensitivity, together with better spatial resolution, which partially compensates for loss of image contrast.( 61)Cu-PTSM and( 64)Cu-PTSM are associated with radiation doses similar to [(18)F]-fluorodeoxyglucose, whilst the doses for( 60)Cu-PTSM and( 62)Cu-PTSM are lower and more comparable with H(2) (15)O. CONCLUSION: The physical and radiochemical characteristics of the four copper isotopes make each more suited to some imaging tasks than others. The results presented here assist in selecting the preferred radioisotope for a given imaging application, and illustrate a strategy which can be extended to the majority of novel PET tracers.
Affiliation:
Christie Hospital NHS Trust, North Western Medical Physics, Wilmslow Road, Manchester, M20 4BX, United Kingdom. hwilliams@physics.org
Citation:
A comparison of PET imaging characteristics of various copper radioisotopes. 2005, 32 (12):1473-80 Eur. J. Nucl. Med. Mol. Imaging
Journal:
European Journal of Nuclear Medicine and Molecular Imaging
Issue Date:
Dec-2005
URI:
http://hdl.handle.net/10541/76828
DOI:
10.1007/s00259-005-1906-9
PubMed ID:
16258764
Type:
Article
Language:
en
ISSN:
1619-7070
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWilliams, Heather-
dc.contributor.authorRobinson, Simon-
dc.contributor.authorJulyan, Peter J-
dc.contributor.authorZweit, Jamal-
dc.contributor.authorHastings, David L-
dc.date.accessioned2009-08-10T17:10:07Z-
dc.date.available2009-08-10T17:10:07Z-
dc.date.issued2005-12-
dc.identifier.citationA comparison of PET imaging characteristics of various copper radioisotopes. 2005, 32 (12):1473-80 Eur. J. Nucl. Med. Mol. Imagingen
dc.identifier.issn1619-7070-
dc.identifier.pmid16258764-
dc.identifier.doi10.1007/s00259-005-1906-9-
dc.identifier.urihttp://hdl.handle.net/10541/76828-
dc.description.abstractPURPOSE: PET radiotracers which incorporate longer-lived radionuclides enable biological processes to be studied over many hours, at centres remote from a cyclotron. This paper examines the radioisotope characteristics, imaging performance, radiation dosimetry and production modes of the four copper radioisotopes, ( 60)Cu,( 61)Cu,( 62)Cu and( 64)Cu, to assess their merits for different PET imaging applications. METHODS: Spatial resolution, sensitivity, scatter fraction and noise-equivalent count rate (NEC) are predicted for( 60)Cu,( 61)Cu,( 62)Cu and( 64)Cu using a model incorporating radionuclide decay properties and scanner parameters for the GE Advance scanner. Dosimetry for( 60)Cu,( 61)Cu and( 64)Cu is performed using the MIRD model and published biodistribution data for copper(II) pyruvaldehyde bis(N(4)-methyl)thiosemicarbazone (Cu-PTSM). RESULTS: (60)Cu and( 62)Cu are characterised by shorter half-lives and higher sensitivity and NEC, making them more suitable for studying the faster kinetics of small molecules, such as Cu-PTSM.( 61)Cu and( 64)Cu have longer half-lives, enabling studies of the slower kinetics of cells and peptides and prolonged imaging to compensate for lower sensitivity, together with better spatial resolution, which partially compensates for loss of image contrast.( 61)Cu-PTSM and( 64)Cu-PTSM are associated with radiation doses similar to [(18)F]-fluorodeoxyglucose, whilst the doses for( 60)Cu-PTSM and( 62)Cu-PTSM are lower and more comparable with H(2) (15)O. CONCLUSION: The physical and radiochemical characteristics of the four copper isotopes make each more suited to some imaging tasks than others. The results presented here assist in selecting the preferred radioisotope for a given imaging application, and illustrate a strategy which can be extended to the majority of novel PET tracers.en
dc.language.isoenen
dc.subject.meshComputer Simulation-
dc.subject.meshCopper Radioisotopes-
dc.subject.meshHalf-Life-
dc.subject.meshHumans-
dc.subject.meshImage Interpretation, Computer-Assisted-
dc.subject.meshModels, Biological-
dc.subject.meshPositron-Emission Tomography-
dc.subject.meshRadiation Dosage-
dc.subject.meshRadiometry-
dc.subject.meshRadiopharmaceuticals-
dc.titleA comparison of PET imaging characteristics of various copper radioisotopes.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital NHS Trust, North Western Medical Physics, Wilmslow Road, Manchester, M20 4BX, United Kingdom. hwilliams@physics.orgen
dc.identifier.journalEuropean Journal of Nuclear Medicine and Molecular Imagingen

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