Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting.

2.50
Hdl Handle:
http://hdl.handle.net/10541/76801
Title:
Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting.
Authors:
West, Catharine M L; McKay, Michael J; Hölscher, Tobias; Baumann, Michael; Stratford, Ian J; Bristow, Robert G; Iwakawa, Mayumi; Imai, Takashi; Zingde, Surekha M; Anscher, Mitchell S; Bourhis, Jean; Begg, Adrian C; Haustermans, Karin; Bentzen, Soren M; Hendry, Jolyon H
Abstract:
PURPOSE: There is increasing interest in radiogenomics and the characterization of molecular profiles that predict normal tissue and tumor radioresponse. A meeting in Amsterdam was organized by the International Atomic Energy Agency to discuss this topic on an international basis. METHODS AND MATERIALS: This report is not completely exhaustive, but highlights some of the ongoing studies and new initiatives being carried out worldwide in the banking of tumor and normal tissue samples underpinning the development of molecular marker profiles for predicting patient response to radiotherapy. It is generally considered that these profiles will more accurately define individual or group radiosensitivities compared with the nondefinitive findings from the previous era of cellular-based techniques. However, so far there are only a few robust reports of molecular markers predicting normal tissue or tumor response. RESULTS: Many centers in different countries have initiated tissue and tumor banks to store samples from clinical trials for future molecular profiling analysis, to identify profiles that predict for radiotherapy response. The European Society for Therapeutic Radiology and Oncology GENEtic pathways for the Prediction of the effects of Irradiation (GENEPI) project, to store, document, and analyze sample characteristics vs. response, is the most comprehensive in this regard. CONCLUSIONS: The next 5-10 years are likely to see the results of these and other correlative studies, and promising associations of profiles with response should be validated in larger definitive trials.
Affiliation:
Academic Department of Radiation Oncology, The University of Manchester, Christie Hospital NHS Trust, Withington, Manchester, UK.
Citation:
Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting. 2005, 62 (5):1264-73 Int. J. Radiat. Oncol. Biol. Phys.
Journal:
International Journal of Radiation Oncology, Biology, Physics
Issue Date:
1-Aug-2005
URI:
http://hdl.handle.net/10541/76801
DOI:
10.1016/j.ijrobp.2005.05.001
PubMed ID:
16029781
Type:
Article
Language:
en
ISSN:
0360-3016
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorWest, Catharine M L-
dc.contributor.authorMcKay, Michael J-
dc.contributor.authorHölscher, Tobias-
dc.contributor.authorBaumann, Michael-
dc.contributor.authorStratford, Ian J-
dc.contributor.authorBristow, Robert G-
dc.contributor.authorIwakawa, Mayumi-
dc.contributor.authorImai, Takashi-
dc.contributor.authorZingde, Surekha M-
dc.contributor.authorAnscher, Mitchell S-
dc.contributor.authorBourhis, Jean-
dc.contributor.authorBegg, Adrian C-
dc.contributor.authorHaustermans, Karin-
dc.contributor.authorBentzen, Soren M-
dc.contributor.authorHendry, Jolyon H-
dc.date.accessioned2009-08-10T10:21:17Z-
dc.date.available2009-08-10T10:21:17Z-
dc.date.issued2005-08-01-
dc.identifier.citationMolecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting. 2005, 62 (5):1264-73 Int. J. Radiat. Oncol. Biol. Phys.en
dc.identifier.issn0360-3016-
dc.identifier.pmid16029781-
dc.identifier.doi10.1016/j.ijrobp.2005.05.001-
dc.identifier.urihttp://hdl.handle.net/10541/76801-
dc.description.abstractPURPOSE: There is increasing interest in radiogenomics and the characterization of molecular profiles that predict normal tissue and tumor radioresponse. A meeting in Amsterdam was organized by the International Atomic Energy Agency to discuss this topic on an international basis. METHODS AND MATERIALS: This report is not completely exhaustive, but highlights some of the ongoing studies and new initiatives being carried out worldwide in the banking of tumor and normal tissue samples underpinning the development of molecular marker profiles for predicting patient response to radiotherapy. It is generally considered that these profiles will more accurately define individual or group radiosensitivities compared with the nondefinitive findings from the previous era of cellular-based techniques. However, so far there are only a few robust reports of molecular markers predicting normal tissue or tumor response. RESULTS: Many centers in different countries have initiated tissue and tumor banks to store samples from clinical trials for future molecular profiling analysis, to identify profiles that predict for radiotherapy response. The European Society for Therapeutic Radiology and Oncology GENEtic pathways for the Prediction of the effects of Irradiation (GENEPI) project, to store, document, and analyze sample characteristics vs. response, is the most comprehensive in this regard. CONCLUSIONS: The next 5-10 years are likely to see the results of these and other correlative studies, and promising associations of profiles with response should be validated in larger definitive trials.en
dc.language.isoenen
dc.subjectCanceren
dc.subjectTumour Markersen
dc.subject.meshDatabases, Factual-
dc.subject.meshGenetic Markers-
dc.subject.meshHealth Planning Guidelines-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshRadiation Injuries-
dc.subject.meshRadiation Tolerance-
dc.subject.meshTissue Banks-
dc.subject.meshTreatment Outcome-
dc.subject.meshTumor Markers, Biological-
dc.titleMolecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting.en
dc.typeArticleen
dc.contributor.departmentAcademic Department of Radiation Oncology, The University of Manchester, Christie Hospital NHS Trust, Withington, Manchester, UK.en
dc.identifier.journalInternational Journal of Radiation Oncology, Biology, Physicsen

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