Regressed cutaneous malignant melanoma mimicking lymphoma: a potential diagnostic pitfall.

2.50
Hdl Handle:
http://hdl.handle.net/10541/76780
Title:
Regressed cutaneous malignant melanoma mimicking lymphoma: a potential diagnostic pitfall.
Authors:
Menasce, Lia P; Shanks, Jonathan H; Howarth, V S; Banerjee, Saumitra S
Abstract:
We report 2 cases of partially regressed malignant melanoma in which the brisk lymphocytic response closely resembled mycosis fungoides in 1 case and nodular sclerosing Hodgkin lymphoma in the other. Striking epidermotropism was present in both cases. The lymphocytes were predominantly of T8 cytotoxic subtype, and oligoclonal T-cell expansion was detected in 1 of the cases. The scanty residual melanoma cells were highlighted with HMB45 and S100 protein. We highlight the features of regression in melanoma that may lead to an erroneous diagnosis of lymphoma and discuss the finding of oligoclonal T-cell expansion in regressed melanocytic lesions.
Affiliation:
Department of Pathology, Christie Hospital NHS Trust, Withington, Manchester, UK.
Citation:
Regressed cutaneous malignant melanoma mimicking lymphoma: a potential diagnostic pitfall. 2005, 13 (3):281-4 Int. J. Surg. Pathol.
Journal:
International Journal of Surgical Pathology
Issue Date:
Jul-2005
URI:
http://hdl.handle.net/10541/76780
PubMed ID:
16086086
Type:
Article
Language:
en
ISSN:
1066-8969
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMenasce, Lia P-
dc.contributor.authorShanks, Jonathan H-
dc.contributor.authorHowarth, V S-
dc.contributor.authorBanerjee, Saumitra S-
dc.date.accessioned2009-08-10T10:26:59Z-
dc.date.available2009-08-10T10:26:59Z-
dc.date.issued2005-07-
dc.identifier.citationRegressed cutaneous malignant melanoma mimicking lymphoma: a potential diagnostic pitfall. 2005, 13 (3):281-4 Int. J. Surg. Pathol.en
dc.identifier.issn1066-8969-
dc.identifier.pmid16086086-
dc.identifier.urihttp://hdl.handle.net/10541/76780-
dc.description.abstractWe report 2 cases of partially regressed malignant melanoma in which the brisk lymphocytic response closely resembled mycosis fungoides in 1 case and nodular sclerosing Hodgkin lymphoma in the other. Striking epidermotropism was present in both cases. The lymphocytes were predominantly of T8 cytotoxic subtype, and oligoclonal T-cell expansion was detected in 1 of the cases. The scanty residual melanoma cells were highlighted with HMB45 and S100 protein. We highlight the features of regression in melanoma that may lead to an erroneous diagnosis of lymphoma and discuss the finding of oligoclonal T-cell expansion in regressed melanocytic lesions.en
dc.language.isoenen
dc.subjectCancer Regressionen
dc.subjectSkin Canceren
dc.subjectTumour Markersen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshClone Cells-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshDiagnostic Errors-
dc.subject.meshFemale-
dc.subject.meshHodgkin Disease-
dc.subject.meshHumans-
dc.subject.meshMelanoma-
dc.subject.meshMiddle Aged-
dc.subject.meshMycosis Fungoides-
dc.subject.meshNeoplasm Regression, Spontaneous-
dc.subject.meshSkin Neoplasms-
dc.subject.meshT-Lymphocyte Subsets-
dc.subject.meshTumor Markers, Biological-
dc.titleRegressed cutaneous malignant melanoma mimicking lymphoma: a potential diagnostic pitfall.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Christie Hospital NHS Trust, Withington, Manchester, UK.en
dc.identifier.journalInternational Journal of Surgical Pathologyen

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