Quality of life in childhood onset growth hormone-deficient patients in the transition phase from childhood to adulthood.

2.50
Hdl Handle:
http://hdl.handle.net/10541/76560
Title:
Quality of life in childhood onset growth hormone-deficient patients in the transition phase from childhood to adulthood.
Authors:
Attanasio, Andrea F; Shavrikova, Elena; Blum, Werner F; Shalet, Stephen M
Abstract:
BACKGROUND: Quality of life (QoL) has not been specifically assessed in GH-deficient (GHD) transition patients. METHODS: We assessed QoL at baseline and after 1 and 2 yr of GH treatment in severely GHD patients, using an adult GHD-specific questionnaire, QLS(M)-H. Subjects were randomized to GH, 25.0 microg/kg.d (n = 25) or 12.5 microg/kg.d (n = 28), or no treatment (n = 13). sd scores for QLS-H were calculated from normative data, specific to country of origin, gender, and age range of the patients. RESULTS: Baseline QLS-H sd scores were -0.35 +/- 1.17 in females and -0.70 +/- 1.05 in males (P = 0.280). sd scores for individual dimensions of ability to become sexually aroused, ability to tolerate stress, body shape, concentration, initiative/drive, physical stamina, and self-confidence were significantly lower than the normal average. Particularly affected were body shape (sd score, -0.80 +/- 0.99; quartile (Q)1:Q3, -1.52:-0.29) and sexual arousal (sd score, -0.41 +/- 0.88; Q1:Q3, -1.15:-0.13). Total QLS-H sd score increased slightly but not significantly for combined GH treatment groups compared with control at yr 1 (0.047 +/- 1.51 vs. -0.32 +/- 1.66; P = 0.845) but not after yr 2 (-0.00 +/- 0.80 vs. 0.12 +/- 0.89; P = 0.385); no dose effect of GH was observed. GH treatment significantly increased sd score from baseline to yr 2 for sexual arousal and body shape (0.23 +/- 0.78, P = 0.038; and 0.46 +/- 1.26, P = 0.035, respectively). CONCLUSION: Although overall baseline QoL was not compromised in severely GHD patients during the transition period, dimensions related to age-specific psychological problems were significantly worse than healthy subjects and appeared to positively respond to GH treatment.
Affiliation:
Casina del Rosone, Agliano Terme, Italy.
Citation:
Quality of life in childhood onset growth hormone-deficient patients in the transition phase from childhood to adulthood. 2005, 90 (8):4525-9 J. Clin. Endocrinol. Metab.
Journal:
The Journal of Clinical Endocrinology and Metabolism
Issue Date:
Aug-2005
URI:
http://hdl.handle.net/10541/76560
DOI:
10.1210/jc.2005-0439
PubMed ID:
15899956
Type:
Article
Language:
en
ISSN:
0021-972X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorAttanasio, Andrea F-
dc.contributor.authorShavrikova, Elena-
dc.contributor.authorBlum, Werner F-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-08-06T14:27:46Z-
dc.date.available2009-08-06T14:27:46Z-
dc.date.issued2005-08-
dc.identifier.citationQuality of life in childhood onset growth hormone-deficient patients in the transition phase from childhood to adulthood. 2005, 90 (8):4525-9 J. Clin. Endocrinol. Metab.en
dc.identifier.issn0021-972X-
dc.identifier.pmid15899956-
dc.identifier.doi10.1210/jc.2005-0439-
dc.identifier.urihttp://hdl.handle.net/10541/76560-
dc.description.abstractBACKGROUND: Quality of life (QoL) has not been specifically assessed in GH-deficient (GHD) transition patients. METHODS: We assessed QoL at baseline and after 1 and 2 yr of GH treatment in severely GHD patients, using an adult GHD-specific questionnaire, QLS(M)-H. Subjects were randomized to GH, 25.0 microg/kg.d (n = 25) or 12.5 microg/kg.d (n = 28), or no treatment (n = 13). sd scores for QLS-H were calculated from normative data, specific to country of origin, gender, and age range of the patients. RESULTS: Baseline QLS-H sd scores were -0.35 +/- 1.17 in females and -0.70 +/- 1.05 in males (P = 0.280). sd scores for individual dimensions of ability to become sexually aroused, ability to tolerate stress, body shape, concentration, initiative/drive, physical stamina, and self-confidence were significantly lower than the normal average. Particularly affected were body shape (sd score, -0.80 +/- 0.99; quartile (Q)1:Q3, -1.52:-0.29) and sexual arousal (sd score, -0.41 +/- 0.88; Q1:Q3, -1.15:-0.13). Total QLS-H sd score increased slightly but not significantly for combined GH treatment groups compared with control at yr 1 (0.047 +/- 1.51 vs. -0.32 +/- 1.66; P = 0.845) but not after yr 2 (-0.00 +/- 0.80 vs. 0.12 +/- 0.89; P = 0.385); no dose effect of GH was observed. GH treatment significantly increased sd score from baseline to yr 2 for sexual arousal and body shape (0.23 +/- 0.78, P = 0.038; and 0.46 +/- 1.26, P = 0.035, respectively). CONCLUSION: Although overall baseline QoL was not compromised in severely GHD patients during the transition period, dimensions related to age-specific psychological problems were significantly worse than healthy subjects and appeared to positively respond to GH treatment.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAge of Onset-
dc.subject.meshFemale-
dc.subject.meshGrowth Disorders-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshQuality of Life-
dc.subject.meshQuestionnaires-
dc.subject.meshStress, Psychological-
dc.titleQuality of life in childhood onset growth hormone-deficient patients in the transition phase from childhood to adulthood.en
dc.typeArticleen
dc.contributor.departmentCasina del Rosone, Agliano Terme, Italy.en
dc.identifier.journalThe Journal of Clinical Endocrinology and Metabolismen

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