Voice abnormality in adults with congenital and adult-acquired growth hormone deficiency.

2.50
Hdl Handle:
http://hdl.handle.net/10541/76523
Title:
Voice abnormality in adults with congenital and adult-acquired growth hormone deficiency.
Authors:
Moore, Christopher J; Shalet, Stephen M; Manickam, Kathiresan; Willard, Terry; Maheshwari, Hiralal G; Baumann, Gerhard
Abstract:
CONTEXT: Adult males with congenital, untreated, severe GH deficiency (GHD) due to genetic GHRH receptor deficiency exhibit distinctive, high-pitched, and raspy voice characteristics. OBJECTIVE/DESIGN: To determine the physical underpinning of this phenomenon, we performed voice recordings, translarynx impedance measurements, spectral analysis, and estimates of spectral complexity [approximate entropy (ApEn)] in four affected men. Results were compared with those obtained in four men with untreated adult-onset GHD and a normal male population. RESULTS: Congenital GHD subjects had a high-pitched voice with a fundamental frequency typical of normal females (174-266 Hz). Their frequency spectra were characterized by abnormal harmonics, with reversal/interruption of the normal amplitude decay among higher-order harmonics, findings consistent with a creaky quality of the voice. Patients with adult-onset GHD, acquired at ages 31, 38, and 40 yr, had a normal male pitch (fundamental frequency, 117-154 Hz) but pathologically low ApEn values, corresponding to a breathy quality of the voice and suggesting abnormal vocal fold function. A fourth patient who acquired GHD at age 22 yr had a pitch intermediate between male and female, high ApEn, and a spectral pattern similar to the congenital GHD patients. CONCLUSIONS: This study demonstrates an effect of GH on laryngeal size and vocal fold compliance that results in a high pitch and disordered spectral quality. The time of onset of GHD determines which type of abnormality predominates.
Affiliation:
North Western Medical Physics, Christie Hospital, Manchester, United Kingdom. chris.moore@physics.cr.man.ac.uk
Citation:
Voice abnormality in adults with congenital and adult-acquired growth hormone deficiency. 2005, 90 (7):4128-32 J. Clin. Endocrinol. Metab.
Journal:
The Journal of Clinical Endocrinology and Metabolism
Issue Date:
Jul-2005
URI:
http://hdl.handle.net/10541/76523
DOI:
10.1210/jc.2004-2558
PubMed ID:
15870127
Type:
Article
Language:
en
ISSN:
0021-972X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMoore, Christopher J-
dc.contributor.authorShalet, Stephen M-
dc.contributor.authorManickam, Kathiresan-
dc.contributor.authorWillard, Terry-
dc.contributor.authorMaheshwari, Hiralal G-
dc.contributor.authorBaumann, Gerhard-
dc.date.accessioned2009-08-06T14:15:55Z-
dc.date.available2009-08-06T14:15:55Z-
dc.date.issued2005-07-
dc.identifier.citationVoice abnormality in adults with congenital and adult-acquired growth hormone deficiency. 2005, 90 (7):4128-32 J. Clin. Endocrinol. Metab.en
dc.identifier.issn0021-972X-
dc.identifier.pmid15870127-
dc.identifier.doi10.1210/jc.2004-2558-
dc.identifier.urihttp://hdl.handle.net/10541/76523-
dc.description.abstractCONTEXT: Adult males with congenital, untreated, severe GH deficiency (GHD) due to genetic GHRH receptor deficiency exhibit distinctive, high-pitched, and raspy voice characteristics. OBJECTIVE/DESIGN: To determine the physical underpinning of this phenomenon, we performed voice recordings, translarynx impedance measurements, spectral analysis, and estimates of spectral complexity [approximate entropy (ApEn)] in four affected men. Results were compared with those obtained in four men with untreated adult-onset GHD and a normal male population. RESULTS: Congenital GHD subjects had a high-pitched voice with a fundamental frequency typical of normal females (174-266 Hz). Their frequency spectra were characterized by abnormal harmonics, with reversal/interruption of the normal amplitude decay among higher-order harmonics, findings consistent with a creaky quality of the voice. Patients with adult-onset GHD, acquired at ages 31, 38, and 40 yr, had a normal male pitch (fundamental frequency, 117-154 Hz) but pathologically low ApEn values, corresponding to a breathy quality of the voice and suggesting abnormal vocal fold function. A fourth patient who acquired GHD at age 22 yr had a pitch intermediate between male and female, high ApEn, and a spectral pattern similar to the congenital GHD patients. CONCLUSIONS: This study demonstrates an effect of GH on laryngeal size and vocal fold compliance that results in a high pitch and disordered spectral quality. The time of onset of GHD determines which type of abnormality predominates.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMutation-
dc.subject.meshReceptors, Somatotropin-
dc.subject.meshVoice Disorders-
dc.titleVoice abnormality in adults with congenital and adult-acquired growth hormone deficiency.en
dc.typeArticleen
dc.contributor.departmentNorth Western Medical Physics, Christie Hospital, Manchester, United Kingdom. chris.moore@physics.cr.man.ac.uken
dc.identifier.journalThe Journal of Clinical Endocrinology and Metabolismen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.