2.50
Hdl Handle:
http://hdl.handle.net/10541/76443
Title:
Hypopituitarism after cranial irradiation.
Authors:
Darzy, Ken H; Shalet, Stephen M
Abstract:
Radiation-induced damage to the hypothalamic-pituitary (h-p) axis is associated with a wide spectrum of subtle and frank abnormalities in anterior pituitary hormones secretion. While the rapidity of onset of these abnormalities is primarily radiation dose-dependent, their frequency and severity also depend on the length of follow-up. The GH axis is the most vulnerable to radiation damage, and GH deficiency is usually the only neuro-endocrine abnormality following irradiation of the h-p axis with doses <30 Gy. With higher radiation doses (30-50 Gy), the frequency of GH insufficiency can be as high as 50-100% and that of TSH and ACTH around 3-6%. Abnormalities in gonadotrophin secretion are dose-dependent; precocious puberty can occur after radiation dose <30 Gy in girls only, and in both sexes equally with a radiation dose of 30-50 Gy. Gonadotrophin deficiency occurs infrequently, and is usually a long-term complication following a minimum radiation dose of 30 Gy. Hyperprolactinemia has been described in both sexes and all ages, but is mostly seen in young women after intensive irradiation and is usually subclinical. A much higher incidence of gonadotrophin, ACTH and TSH deficiencies, (30-60% after 10 yr) occurs after more intensive irradiation (>70 Gy) used for nasopharyngeal carcinomas and tumors of the skull base, and following conventional irradiation (30-50 Gy) for pituitary tumors. Radiation-induced anterior pituitary hormone deficiencies are irreversible and progressive. Regular testing is mandatory to ensure timely diagnosis and early hormone replacement therapy, to improve linear growth and prevent short stature in children cured from cancer, to preserve sexual function, prevent ill health and osteoporosis, and improve the quality of life.
Affiliation:
Department of Endocrinology, The Christie Hospital, Manchester, UK.
Citation:
Hypopituitarism after cranial irradiation. 2005, 28 (5 Suppl):78-87 J. Endocrinol. Invest.
Journal:
Journal of Endocrinological Investigation
Issue Date:
2005
URI:
http://hdl.handle.net/10541/76443
PubMed ID:
16114281
Type:
Article
Language:
en
ISSN:
0391-4097
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDarzy, Ken H-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-08-06T10:16:08Z-
dc.date.available2009-08-06T10:16:08Z-
dc.date.issued2005-
dc.identifier.citationHypopituitarism after cranial irradiation. 2005, 28 (5 Suppl):78-87 J. Endocrinol. Invest.en
dc.identifier.issn0391-4097-
dc.identifier.pmid16114281-
dc.identifier.urihttp://hdl.handle.net/10541/76443-
dc.description.abstractRadiation-induced damage to the hypothalamic-pituitary (h-p) axis is associated with a wide spectrum of subtle and frank abnormalities in anterior pituitary hormones secretion. While the rapidity of onset of these abnormalities is primarily radiation dose-dependent, their frequency and severity also depend on the length of follow-up. The GH axis is the most vulnerable to radiation damage, and GH deficiency is usually the only neuro-endocrine abnormality following irradiation of the h-p axis with doses <30 Gy. With higher radiation doses (30-50 Gy), the frequency of GH insufficiency can be as high as 50-100% and that of TSH and ACTH around 3-6%. Abnormalities in gonadotrophin secretion are dose-dependent; precocious puberty can occur after radiation dose <30 Gy in girls only, and in both sexes equally with a radiation dose of 30-50 Gy. Gonadotrophin deficiency occurs infrequently, and is usually a long-term complication following a minimum radiation dose of 30 Gy. Hyperprolactinemia has been described in both sexes and all ages, but is mostly seen in young women after intensive irradiation and is usually subclinical. A much higher incidence of gonadotrophin, ACTH and TSH deficiencies, (30-60% after 10 yr) occurs after more intensive irradiation (>70 Gy) used for nasopharyngeal carcinomas and tumors of the skull base, and following conventional irradiation (30-50 Gy) for pituitary tumors. Radiation-induced anterior pituitary hormone deficiencies are irreversible and progressive. Regular testing is mandatory to ensure timely diagnosis and early hormone replacement therapy, to improve linear growth and prevent short stature in children cured from cancer, to preserve sexual function, prevent ill health and osteoporosis, and improve the quality of life.en
dc.language.isoenen
dc.subjectBrain Canceren
dc.subject.meshBrain Neoplasms-
dc.subject.meshHumans-
dc.subject.meshHypopituitarism-
dc.subject.meshRadiation Injuries-
dc.titleHypopituitarism after cranial irradiation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, The Christie Hospital, Manchester, UK.en
dc.identifier.journalJournal of Endocrinological Investigationen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.