Do early premalignant changes in normal breast epithelial cells predict cancer development?

2.50
Hdl Handle:
http://hdl.handle.net/10541/76284
Title:
Do early premalignant changes in normal breast epithelial cells predict cancer development?
Authors:
Clarke, Robert B; Bundred, Nigel J
Abstract:
A recent report suggests that, in an in vitro model of premalignant breast cells (vHMECs), silencing of INK4A gene is accompanied by over-expression of cyclo-oxygenase (COX)-2. This suggests that COX-2 over-expression may be an early event in breast cancer aetiology permitting clones within the normal epithelium to evade apoptosis, to increase their numbers and perhaps acquire further changes that promote the formation of hyperplasias, and eventually carcinomas. While COX-2 expression in normal breast epithelium in vivo has not been proven to be linked to an increased risk of breast cancer, its over-expression in the premalignant model in vitro does provide preliminary evidence that COX-2 inhibition may be a useful chemoprevention strategy.
Affiliation:
CR-UK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Do early premalignant changes in normal breast epithelial cells predict cancer development? 2005, 7 (1):18-20 Breast Cancer Res.
Journal:
Breast Cancer Research
Issue Date:
2005
URI:
http://hdl.handle.net/10541/76284
DOI:
10.1186/bcr967
PubMed ID:
15642177
Type:
Article
Language:
en
ISSN:
1465-542X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorClarke, Robert B-
dc.contributor.authorBundred, Nigel J-
dc.date.accessioned2009-08-04T17:31:13Z-
dc.date.available2009-08-04T17:31:13Z-
dc.date.issued2005-
dc.identifier.citationDo early premalignant changes in normal breast epithelial cells predict cancer development? 2005, 7 (1):18-20 Breast Cancer Res.en
dc.identifier.issn1465-542X-
dc.identifier.pmid15642177-
dc.identifier.doi10.1186/bcr967-
dc.identifier.urihttp://hdl.handle.net/10541/76284-
dc.description.abstractA recent report suggests that, in an in vitro model of premalignant breast cells (vHMECs), silencing of INK4A gene is accompanied by over-expression of cyclo-oxygenase (COX)-2. This suggests that COX-2 over-expression may be an early event in breast cancer aetiology permitting clones within the normal epithelium to evade apoptosis, to increase their numbers and perhaps acquire further changes that promote the formation of hyperplasias, and eventually carcinomas. While COX-2 expression in normal breast epithelium in vivo has not been proven to be linked to an increased risk of breast cancer, its over-expression in the premalignant model in vitro does provide preliminary evidence that COX-2 inhibition may be a useful chemoprevention strategy.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer Invasivenessen
dc.subject.meshApoptosis-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshCyclin-Dependent Kinase Inhibitor p16-
dc.subject.meshCyclooxygenase 2-
dc.subject.meshCyclooxygenase Inhibitors-
dc.subject.meshEpithelial Cells-
dc.subject.meshFemale-
dc.subject.meshGene Silencing-
dc.subject.meshHumans-
dc.subject.meshHyperplasia-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshPrecancerous Conditions-
dc.subject.meshRisk Factors-
dc.titleDo early premalignant changes in normal breast epithelial cells predict cancer development?en
dc.typeArticleen
dc.contributor.departmentCR-UK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalBreast Cancer Researchen

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