Toward personalized immunotherapy for non-Hodgkin lymphoma: targeting the idiotypic immunoglobulin.

2.50
Hdl Handle:
http://hdl.handle.net/10541/76273
Title:
Toward personalized immunotherapy for non-Hodgkin lymphoma: targeting the idiotypic immunoglobulin.
Authors:
Armstrong, Anne C; Cheadle, Eleanor J; Hawkins, Robert E
Abstract:
The idiotypic determinants of B-cell lymphomas, formed by cell-specific rearrangement of the immunoglobulin genes, are unique and are therefore a suitable target against which to direct immunotherapy. Recent advances in our understanding of the fundamental mechanisms behind an effective immune response, coupled with advances in genetic engineering techniques, have led to a renewed interest in immunotherapy. Early clinical studies have confirmed the immunogenicity of the idiotypic antigen in patients with lymphoma. This review discusses the different methods of idiotypic vaccination currently under investigation in the clinic, including protein, genetic, and cellular vaccines. Protein vaccines are the most clinically advanced, with phase III trials of idiotypic protein linked to GM-CSF currently underway. DNA vaccines are easier to produce but to date only appear to be weakly immunogenic in man. Dendritic cell vaccines have shown promise but their use may be limited by the complexity of this approach. This review also highlights other approaches not yet in the clinic but that have shown promise in the laboratory, such as viral vaccines and T-cell therapy.
Affiliation:
Cancer Research UK Department of Medical Oncology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Toward personalized immunotherapy for non-Hodgkin lymphoma: targeting the idiotypic immunoglobulin. 2005, 19 (5):289-97 BioDrugs
Journal:
BioDrugs
Issue Date:
2005
URI:
http://hdl.handle.net/10541/76273
PubMed ID:
16207070
Type:
Article
Language:
en
ISSN:
1173-8804
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorArmstrong, Anne C-
dc.contributor.authorCheadle, Eleanor J-
dc.contributor.authorHawkins, Robert E-
dc.date.accessioned2009-08-04T17:10:02Z-
dc.date.available2009-08-04T17:10:02Z-
dc.date.issued2005-
dc.identifier.citationToward personalized immunotherapy for non-Hodgkin lymphoma: targeting the idiotypic immunoglobulin. 2005, 19 (5):289-97 BioDrugsen
dc.identifier.issn1173-8804-
dc.identifier.pmid16207070-
dc.identifier.urihttp://hdl.handle.net/10541/76273-
dc.description.abstractThe idiotypic determinants of B-cell lymphomas, formed by cell-specific rearrangement of the immunoglobulin genes, are unique and are therefore a suitable target against which to direct immunotherapy. Recent advances in our understanding of the fundamental mechanisms behind an effective immune response, coupled with advances in genetic engineering techniques, have led to a renewed interest in immunotherapy. Early clinical studies have confirmed the immunogenicity of the idiotypic antigen in patients with lymphoma. This review discusses the different methods of idiotypic vaccination currently under investigation in the clinic, including protein, genetic, and cellular vaccines. Protein vaccines are the most clinically advanced, with phase III trials of idiotypic protein linked to GM-CSF currently underway. DNA vaccines are easier to produce but to date only appear to be weakly immunogenic in man. Dendritic cell vaccines have shown promise but their use may be limited by the complexity of this approach. This review also highlights other approaches not yet in the clinic but that have shown promise in the laboratory, such as viral vaccines and T-cell therapy.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshCancer Vaccines-
dc.subject.meshDendritic Cells-
dc.subject.meshHumans-
dc.subject.meshImmunoglobulin Idiotypes-
dc.subject.meshImmunotherapy-
dc.subject.meshLymphoma, B-Cell-
dc.subject.meshVaccines, DNA-
dc.titleToward personalized immunotherapy for non-Hodgkin lymphoma: targeting the idiotypic immunoglobulin.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Department of Medical Oncology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalBioDrugsen

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