Is there a common aetiology for certain childhood malignancies? Results of cross-space-time clustering analyses.

2.50
Hdl Handle:
http://hdl.handle.net/10541/75873
Title:
Is there a common aetiology for certain childhood malignancies? Results of cross-space-time clustering analyses.
Authors:
McNally, R J Q; Eden, Tim O B; Alexander, F E; Kelsey, Anna M; Birch, Jillian M
Abstract:
We previously demonstrated significant space-time clustering amongst cases of childhood leukaemia (in particular acute lymphoblastic leukaemia (ALL)), central nervous system (CNS) tumour (especially astrocytoma), soft tissue sarcoma and Wilms' tumour. We hypothesised that there may be common aetiological mechanisms between some of these diagnostic groups. To test this hypothesis we analysed for cross-space-time clustering between these diagnostic groups, using population-based data from north-west England. Data were examined by a second-order procedure based on K-functions. Reference points in time and space were dates and addresses at birth and diagnosis. The results showed statistically significant (P < 0.05) cross-clustering between cases of leukaemia and CNS tumour and between cases of ALL and astrocytoma. There was no statistically significant cross-clustering of Wilms' tumours and soft tissue sarcomas with any other malignancy. In conclusion, these findings are consistent with common, possibly infectious, aetiological mechanisms for childhood leukaemia (particularly ALL) and CNS tumours (particularly astrocytoma).
Affiliation:
Sir James Spence Institute, Level 4, Royal Victoria Infirmary, Queen Victoria Road, Newcastle NE1 4LP, UK. Richard.McNally@ncl.ac.uk
Citation:
Is there a common aetiology for certain childhood malignancies? Results of cross-space-time clustering analyses. 2005, 41 (18):2911-6 Eur. J. Cancer
Journal:
European Journal of Cancer
Issue Date:
Dec-2005
URI:
http://hdl.handle.net/10541/75873
DOI:
10.1016/j.ejca.2005.04.051
PubMed ID:
16243517
Type:
Article
Language:
en
ISSN:
0959-8049
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMcNally, R J Q-
dc.contributor.authorEden, Tim O B-
dc.contributor.authorAlexander, F E-
dc.contributor.authorKelsey, Anna M-
dc.contributor.authorBirch, Jillian M-
dc.date.accessioned2009-07-29T13:52:32Z-
dc.date.available2009-07-29T13:52:32Z-
dc.date.issued2005-12-
dc.identifier.citationIs there a common aetiology for certain childhood malignancies? Results of cross-space-time clustering analyses. 2005, 41 (18):2911-6 Eur. J. Canceren
dc.identifier.issn0959-8049-
dc.identifier.pmid16243517-
dc.identifier.doi10.1016/j.ejca.2005.04.051-
dc.identifier.urihttp://hdl.handle.net/10541/75873-
dc.description.abstractWe previously demonstrated significant space-time clustering amongst cases of childhood leukaemia (in particular acute lymphoblastic leukaemia (ALL)), central nervous system (CNS) tumour (especially astrocytoma), soft tissue sarcoma and Wilms' tumour. We hypothesised that there may be common aetiological mechanisms between some of these diagnostic groups. To test this hypothesis we analysed for cross-space-time clustering between these diagnostic groups, using population-based data from north-west England. Data were examined by a second-order procedure based on K-functions. Reference points in time and space were dates and addresses at birth and diagnosis. The results showed statistically significant (P < 0.05) cross-clustering between cases of leukaemia and CNS tumour and between cases of ALL and astrocytoma. There was no statistically significant cross-clustering of Wilms' tumours and soft tissue sarcomas with any other malignancy. In conclusion, these findings are consistent with common, possibly infectious, aetiological mechanisms for childhood leukaemia (particularly ALL) and CNS tumours (particularly astrocytoma).en
dc.language.isoenen
dc.subjectCentral Nervous System Canceren
dc.subjectCanceren
dc.subjectPrecursor Cell Lymphoblastic Leukaemiaen
dc.subjectWilms Tumouren
dc.subject.meshAdolescent-
dc.subject.meshAstrocytoma-
dc.subject.meshCentral Nervous System Neoplasms-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshEngland-
dc.subject.meshEnvironment-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshInfant-
dc.subject.meshInfant, Newborn-
dc.subject.meshInfection-
dc.subject.meshNeoplasms-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshResidence Characteristics-
dc.subject.meshSarcoma-
dc.subject.meshSpace-Time Clustering-
dc.subject.meshWilms Tumor-
dc.titleIs there a common aetiology for certain childhood malignancies? Results of cross-space-time clustering analyses.en
dc.typeArticleen
dc.contributor.departmentSir James Spence Institute, Level 4, Royal Victoria Infirmary, Queen Victoria Road, Newcastle NE1 4LP, UK. Richard.McNally@ncl.ac.uken
dc.identifier.journalEuropean Journal of Canceren

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.