Relationships between perinatal and maternal characteristics and hepatoblastoma: a report from the UKCCS.

2.50
Hdl Handle:
http://hdl.handle.net/10541/75861
Title:
Relationships between perinatal and maternal characteristics and hepatoblastoma: a report from the UKCCS.
Authors:
Ansell, Pat; Mitchell, Christopher D; Roman, Eve; Simpson, Jill; Birch, Jillian M; Eden, Tim O B
Abstract:
Within the context of a national population-based case-control study--the United Kingdom Childhood Cancer Study (UKCCS)--we aimed to explore relationships between perinatal and maternal factors and childhood hepatic tumours, for participants with data available from medical records. 26/28 children with hepatic tumours (22/24 hepatoblastomas, 4/4 hepatocellular carcinomas (HCC)) and 4753 age- and sex-matched controls were included. Polyhydramnios was associated with 0.9% of control pregnancies and 13.6% of case pregnancies (Odds Ratio (OR)=28.64, 95% Confidence Interval (CI)=6.94-118.21, P<0.0001); eclampsia or severe pre-eclampsia complicated the pregnancies of 16.7% of mothers whose children developed hepatoblastoma compared with 0.5% of control pregnancies (OR=52.50, 95% CI=10.75-257.05, P<0.0001). Three children with hepatoblastoma weighed <1500 g at birth, two of whom weighed <1000 g (OR for birthweight <1500 g=69.00, 95% CI=11.98-397.17, P<0.0001). Of children with hepatoblastoma, 50% (11/22) had records of congenital anomalies, as did two of their mothers. Three mothers of children with hepatoblastoma had diagnoses of cancer--two of papillary carcinoma of the thyroid and one of acute lymphoblastic leukaemia (ALL). Paediatricians and others should be alert to the possibility of familial or genetic syndromes in children with hepatoblastomas. Potential links between maternal pre-eclampsia, low birthweight and subsequent malignancy merit further investigation. Hepatoblastoma is an extremely rare childhood tumour, but understanding the mechanism(s) underlying severe pre-eclampsia and eclampsia may also shed light on factors that contribute to the development of hepatoblastoma.
Affiliation:
Leukaemia Research Fund Epidemiology and Genetics Unit, Department of Health Sciences, Seebohm Rowntree Building, University of York, York YO10 5DD, UK. pat.ansell@egu.york.ac.uk
Citation:
Relationships between perinatal and maternal characteristics and hepatoblastoma: a report from the UKCCS. 2005, 41 (5):741-8 Eur. J. Cancer
Journal:
European Journal of Cancer
Issue Date:
Mar-2005
URI:
http://hdl.handle.net/10541/75861
DOI:
10.1016/j.ejca.2004.10.024
PubMed ID:
15763651
Type:
Article
Language:
en
ISSN:
0959-8049
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorAnsell, Pat-
dc.contributor.authorMitchell, Christopher D-
dc.contributor.authorRoman, Eve-
dc.contributor.authorSimpson, Jill-
dc.contributor.authorBirch, Jillian M-
dc.contributor.authorEden, Tim O B-
dc.date.accessioned2009-07-29T13:47:52Z-
dc.date.available2009-07-29T13:47:52Z-
dc.date.issued2005-03-
dc.identifier.citationRelationships between perinatal and maternal characteristics and hepatoblastoma: a report from the UKCCS. 2005, 41 (5):741-8 Eur. J. Canceren
dc.identifier.issn0959-8049-
dc.identifier.pmid15763651-
dc.identifier.doi10.1016/j.ejca.2004.10.024-
dc.identifier.urihttp://hdl.handle.net/10541/75861-
dc.description.abstractWithin the context of a national population-based case-control study--the United Kingdom Childhood Cancer Study (UKCCS)--we aimed to explore relationships between perinatal and maternal factors and childhood hepatic tumours, for participants with data available from medical records. 26/28 children with hepatic tumours (22/24 hepatoblastomas, 4/4 hepatocellular carcinomas (HCC)) and 4753 age- and sex-matched controls were included. Polyhydramnios was associated with 0.9% of control pregnancies and 13.6% of case pregnancies (Odds Ratio (OR)=28.64, 95% Confidence Interval (CI)=6.94-118.21, P<0.0001); eclampsia or severe pre-eclampsia complicated the pregnancies of 16.7% of mothers whose children developed hepatoblastoma compared with 0.5% of control pregnancies (OR=52.50, 95% CI=10.75-257.05, P<0.0001). Three children with hepatoblastoma weighed <1500 g at birth, two of whom weighed <1000 g (OR for birthweight <1500 g=69.00, 95% CI=11.98-397.17, P<0.0001). Of children with hepatoblastoma, 50% (11/22) had records of congenital anomalies, as did two of their mothers. Three mothers of children with hepatoblastoma had diagnoses of cancer--two of papillary carcinoma of the thyroid and one of acute lymphoblastic leukaemia (ALL). Paediatricians and others should be alert to the possibility of familial or genetic syndromes in children with hepatoblastomas. Potential links between maternal pre-eclampsia, low birthweight and subsequent malignancy merit further investigation. Hepatoblastoma is an extremely rare childhood tumour, but understanding the mechanism(s) underlying severe pre-eclampsia and eclampsia may also shed light on factors that contribute to the development of hepatoblastoma.en
dc.language.isoenen
dc.subjectLiver Canceren
dc.subjectHaepatoblastomaen
dc.subject.meshCarcinoma, Hepatocellular-
dc.subject.meshCase-Control Studies-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshConfidence Intervals-
dc.subject.meshFemale-
dc.subject.meshHepatoblastoma-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshInfant, Low Birth Weight-
dc.subject.meshInfant, Newborn-
dc.subject.meshLiver Neoplasms-
dc.subject.meshMale-
dc.subject.meshOdds Ratio-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Complications-
dc.titleRelationships between perinatal and maternal characteristics and hepatoblastoma: a report from the UKCCS.en
dc.typeArticleen
dc.contributor.departmentLeukaemia Research Fund Epidemiology and Genetics Unit, Department of Health Sciences, Seebohm Rowntree Building, University of York, York YO10 5DD, UK. pat.ansell@egu.york.ac.uken
dc.identifier.journalEuropean Journal of Canceren

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