Radical radiotherapy alone for glomus jugulare and tympanicum tumours.

2.50
Hdl Handle:
http://hdl.handle.net/10541/75847
Title:
Radical radiotherapy alone for glomus jugulare and tympanicum tumours.
Authors:
Pemberton, Laura S; Swindell, Ric; Sykes, Andrew J
Abstract:
The management of glomus jugulare and tympanicum tumours is controversial due the long natural history and morbidity associated with intervention. We report the experience of radical radiotherapy (RT) alone for these tumours. Between 1965 and 1987, 49 patients received RT. Median age at presentation was 55 years (range, 23-82). Common presentations were deafness in 27 patients, tinnitus in 25 and cranial nerve palsies in 18. RT was given as a 2D simulator-planned wedge pair in the majority with a median dose of 45 Gy (range, 37.5-50.0) in 15 or 16 fractions over 21 days (range, 20-26). Median follow-up was 7.4 years (range, 2.0-23.4). At 6 months post-RT, complete clinical response was seen in 38 patients, partial response in 4, no response in 1 and no data were available for 6. At both 5 and 10 years, 92% of patients were recurrence-free and cancer-specific survival was 96%. There were no reports of radionecrosis. Although tumour eradication is not the aim, RT can achieve good local control, survival and symptom relief without the significant morbidity that can be associated with radical surgery. Therefore, RT alone has a significant role in the management of these tumours.
Affiliation:
Department of Clinical Oncology, Christie Hospital, Manchester, UK.
Citation:
Radical radiotherapy alone for glomus jugulare and tympanicum tumours. 2005, 14 (6):1631-3 Oncol. Rep.
Journal:
Oncology Reports
Issue Date:
Dec-2005
URI:
http://hdl.handle.net/10541/75847
PubMed ID:
16273268
Type:
Article
Language:
en
ISSN:
1021-335X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPemberton, Laura S-
dc.contributor.authorSwindell, Ric-
dc.contributor.authorSykes, Andrew J-
dc.date.accessioned2009-07-29T12:41:20Z-
dc.date.available2009-07-29T12:41:20Z-
dc.date.issued2005-12-
dc.identifier.citationRadical radiotherapy alone for glomus jugulare and tympanicum tumours. 2005, 14 (6):1631-3 Oncol. Rep.en
dc.identifier.issn1021-335X-
dc.identifier.pmid16273268-
dc.identifier.urihttp://hdl.handle.net/10541/75847-
dc.description.abstractThe management of glomus jugulare and tympanicum tumours is controversial due the long natural history and morbidity associated with intervention. We report the experience of radical radiotherapy (RT) alone for these tumours. Between 1965 and 1987, 49 patients received RT. Median age at presentation was 55 years (range, 23-82). Common presentations were deafness in 27 patients, tinnitus in 25 and cranial nerve palsies in 18. RT was given as a 2D simulator-planned wedge pair in the majority with a median dose of 45 Gy (range, 37.5-50.0) in 15 or 16 fractions over 21 days (range, 20-26). Median follow-up was 7.4 years (range, 2.0-23.4). At 6 months post-RT, complete clinical response was seen in 38 patients, partial response in 4, no response in 1 and no data were available for 6. At both 5 and 10 years, 92% of patients were recurrence-free and cancer-specific survival was 96%. There were no reports of radionecrosis. Although tumour eradication is not the aim, RT can achieve good local control, survival and symptom relief without the significant morbidity that can be associated with radical surgery. Therefore, RT alone has a significant role in the management of these tumours.en
dc.language.isoenen
dc.subjectEar Canceren
dc.subjectGlomus Jugulare Tumouren
dc.subjectGlomus Tympanicum Tumouren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshEar Neoplasms-
dc.subject.meshGlomus Jugulare Tumor-
dc.subject.meshGlomus Tympanicum Tumor-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshSurvival Analysis-
dc.subject.meshTime Factors-
dc.subject.meshTreatment Outcome-
dc.titleRadical radiotherapy alone for glomus jugulare and tympanicum tumours.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Christie Hospital, Manchester, UK.en
dc.identifier.journalOncology Reportsen

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