Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes.

2.50
Hdl Handle:
http://hdl.handle.net/10541/75838
Title:
Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes.
Authors:
Le Chevalier, Thierry; Scagliotti, Giorgio V; Natale, Ronald B; Danson, Sarah; Rosell, Rafael; Stahel, R; Thomas, P; Rudd, R M; Vansteenkiste, Johan; Thatcher, Nick; Manegold, Christian; Pujol, J L; Van Zandwijk, N; Gridelli, Cesare; Van Meerbeeck, Jan; Crino, L; Brown, A; Fitzgerald, P; Aristides, M; Schiller, Joan H
Abstract:
PURPOSE: Gemcitabine-platinum combination activity has been clearly established in a number of phase II studies. It has also been compared against other combinations in many phase III trials. It is generally believed that all such regimens have an equivalent impact on survival. This meta-analysis aims to quantify the treatment effect of gemcitabine plus a platinum agent in the treatment of advanced NSCLC and compare the combination to other regimens used globally. DESIGN: Data from a total of 4556 patients from 13 randomized trials investigating gemcitabine in combination with a platinum agent versus any other platinum-containing regimen were included in a meta-analysis of time-to-event outcomes. RESULTS: A significant reduction in overall mortality in favor of gemcitabine-platinum regimens was observed, hazard ratio (HR) 0.90 (95% CI: 0.84-0.96) with an absolute benefit at 1 year of 3.9%. Median survival was 9.0 months for the gemcitabine-platinum regimens and 8.2 months for the comparator regimens. Sub-group analysis of the first- and second-generation platinum-based comparator regimens also indicated a significant benefit for gemcitabine-platinum regimens, HR 0.84 (CI: 0.71-0.9985). Analysis of third-generation agent plus platinum regimens showed a non-significant trend favoring gemcitabine-platinum regimens, HR 0.93 (CI: 0.86-1.01). There was a significant decrease in the risk of disease progression in favor of gemcitabine-platinum regimens, HR 0.88 (CI: 0.82-0.93). An absolute benefit of 4.2% at 1 year was estimated. Median progression-free survival was 5.1 months for gemcitabine-platinum regimens compared with 4.4 months for the comparator regimens. Sub-group analysis indicated a statistically significant progression-free survival benefit for patients assigned to gemcitabine-platinum treatment compared to first- and second-generation platinum regimens, HR 0.85 (CI: 0.77-0.94), and third-generation agent plus platinum regimens, HR 0.89 (CI: 0.82-0.96).
Affiliation:
Institute Gustave-Roussy, 39-53 Rue Camille Desmoulins, F-94800 Villejuif, France. tle-che@igr.fr
Citation:
Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes. 2005, 47 (1):69-80 Lung Cancer
Journal:
Lung Cancer
Issue Date:
Jan-2005
URI:
http://hdl.handle.net/10541/75838
DOI:
10.1016/j.lungcan.2004.10.014
PubMed ID:
15603856
Type:
Article
Language:
en
ISSN:
0169-5002
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLe Chevalier, Thierry-
dc.contributor.authorScagliotti, Giorgio V-
dc.contributor.authorNatale, Ronald B-
dc.contributor.authorDanson, Sarah-
dc.contributor.authorRosell, Rafael-
dc.contributor.authorStahel, R-
dc.contributor.authorThomas, P-
dc.contributor.authorRudd, R M-
dc.contributor.authorVansteenkiste, Johan-
dc.contributor.authorThatcher, Nick-
dc.contributor.authorManegold, Christian-
dc.contributor.authorPujol, J L-
dc.contributor.authorVan Zandwijk, N-
dc.contributor.authorGridelli, Cesare-
dc.contributor.authorVan Meerbeeck, Jan-
dc.contributor.authorCrino, L-
dc.contributor.authorBrown, A-
dc.contributor.authorFitzgerald, P-
dc.contributor.authorAristides, M-
dc.contributor.authorSchiller, Joan H-
dc.date.accessioned2009-07-29T12:21:10Z-
dc.date.available2009-07-29T12:21:10Z-
dc.date.issued2005-01-
dc.identifier.citationEfficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes. 2005, 47 (1):69-80 Lung Canceren
dc.identifier.issn0169-5002-
dc.identifier.pmid15603856-
dc.identifier.doi10.1016/j.lungcan.2004.10.014-
dc.identifier.urihttp://hdl.handle.net/10541/75838-
dc.description.abstractPURPOSE: Gemcitabine-platinum combination activity has been clearly established in a number of phase II studies. It has also been compared against other combinations in many phase III trials. It is generally believed that all such regimens have an equivalent impact on survival. This meta-analysis aims to quantify the treatment effect of gemcitabine plus a platinum agent in the treatment of advanced NSCLC and compare the combination to other regimens used globally. DESIGN: Data from a total of 4556 patients from 13 randomized trials investigating gemcitabine in combination with a platinum agent versus any other platinum-containing regimen were included in a meta-analysis of time-to-event outcomes. RESULTS: A significant reduction in overall mortality in favor of gemcitabine-platinum regimens was observed, hazard ratio (HR) 0.90 (95% CI: 0.84-0.96) with an absolute benefit at 1 year of 3.9%. Median survival was 9.0 months for the gemcitabine-platinum regimens and 8.2 months for the comparator regimens. Sub-group analysis of the first- and second-generation platinum-based comparator regimens also indicated a significant benefit for gemcitabine-platinum regimens, HR 0.84 (CI: 0.71-0.9985). Analysis of third-generation agent plus platinum regimens showed a non-significant trend favoring gemcitabine-platinum regimens, HR 0.93 (CI: 0.86-1.01). There was a significant decrease in the risk of disease progression in favor of gemcitabine-platinum regimens, HR 0.88 (CI: 0.82-0.93). An absolute benefit of 4.2% at 1 year was estimated. Median progression-free survival was 5.1 months for gemcitabine-platinum regimens compared with 4.4 months for the comparator regimens. Sub-group analysis indicated a statistically significant progression-free survival benefit for patients assigned to gemcitabine-platinum treatment compared to first- and second-generation platinum regimens, HR 0.85 (CI: 0.77-0.94), and third-generation agent plus platinum regimens, HR 0.89 (CI: 0.82-0.96).en
dc.language.isoenen
dc.subjectLung Canceren
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshCarboplatin-
dc.subject.meshCarcinoma, Non-Small-Cell Lung-
dc.subject.meshCisplatin-
dc.subject.meshDeoxycytidine-
dc.subject.meshDisease Progression-
dc.subject.meshDisease-Free Survival-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshRandomized Controlled Trials as Topic-
dc.subject.meshRisk Factors-
dc.subject.meshSurvival Analysis-
dc.subject.meshTreatment Outcome-
dc.titleEfficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes.en
dc.typeArticleen
dc.contributor.departmentInstitute Gustave-Roussy, 39-53 Rue Camille Desmoulins, F-94800 Villejuif, France. tle-che@igr.fren
dc.identifier.journalLung Canceren
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