Surgical decisions made by 158 women with hereditary breast cancer aged <50 years.

2.50
Hdl Handle:
http://hdl.handle.net/10541/75825
Title:
Surgical decisions made by 158 women with hereditary breast cancer aged <50 years.
Authors:
Evans, D Gareth R; Lalloo, Fiona; Hopwood, Penelope; Maurice, Andrew; Baildam, Andrew D; Brain, Anne; Barr, Lester; Howell, Anthony ( 0000-0002-3879-5991 )
Abstract:
AIM: To establish the uptake of contralateral risk reducing mastectomy in women informed of their risks and options at time of diagnosis of their primary unilateral breast cancer. METHODS: We have assessed the surgical choices of 70 women diagnosed with breast cancer <50 years as part of a family history surveillance program and fully informed about their contralateral risks and surgical options. We have compared this to women from other surgical clinics who were subsequently found to harbour a pathogenic BRCA1/2 mutation. RESULTS: Sixty-five percent (13/20) of BRCA1/2 mutation carriers and 59% (n=20/34) of those at the highest level of risk pre-diagnosis (33+% lifetime risk) opted for contra-lateral mastectomy in the study sample. In contrast only 10% (n=9/88) women identified as mutation carriers from other clinics opted for such surgery. CONCLUSIONS: We would suggest that women with a significant family history and therefore a high contra-lateral breast cancer risk, should have these risks and management options discussed at the time of diagnosis of breast cancer.
Affiliation:
Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Hathersage Road, Manchester, UK. gareth.evans@cmmc.nhs.uk
Citation:
Surgical decisions made by 158 women with hereditary breast cancer aged <50 years. 2005, 31 (10):1112-8 Eur J Surg Oncol
Journal:
European Journal of Surgical Oncology
Issue Date:
Dec-2005
URI:
http://hdl.handle.net/10541/75825
DOI:
10.1016/j.ejso.2005.05.007
PubMed ID:
16005602
Type:
Article
Language:
en
ISSN:
0748-7983
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEvans, D Gareth R-
dc.contributor.authorLalloo, Fiona-
dc.contributor.authorHopwood, Penelope-
dc.contributor.authorMaurice, Andrew-
dc.contributor.authorBaildam, Andrew D-
dc.contributor.authorBrain, Anne-
dc.contributor.authorBarr, Lester-
dc.contributor.authorHowell, Anthony-
dc.date.accessioned2009-07-29T12:04:20Z-
dc.date.available2009-07-29T12:04:20Z-
dc.date.issued2005-12-
dc.identifier.citationSurgical decisions made by 158 women with hereditary breast cancer aged <50 years. 2005, 31 (10):1112-8 Eur J Surg Oncolen
dc.identifier.issn0748-7983-
dc.identifier.pmid16005602-
dc.identifier.doi10.1016/j.ejso.2005.05.007-
dc.identifier.urihttp://hdl.handle.net/10541/75825-
dc.description.abstractAIM: To establish the uptake of contralateral risk reducing mastectomy in women informed of their risks and options at time of diagnosis of their primary unilateral breast cancer. METHODS: We have assessed the surgical choices of 70 women diagnosed with breast cancer <50 years as part of a family history surveillance program and fully informed about their contralateral risks and surgical options. We have compared this to women from other surgical clinics who were subsequently found to harbour a pathogenic BRCA1/2 mutation. RESULTS: Sixty-five percent (13/20) of BRCA1/2 mutation carriers and 59% (n=20/34) of those at the highest level of risk pre-diagnosis (33+% lifetime risk) opted for contra-lateral mastectomy in the study sample. In contrast only 10% (n=9/88) women identified as mutation carriers from other clinics opted for such surgery. CONCLUSIONS: We would suggest that women with a significant family history and therefore a high contra-lateral breast cancer risk, should have these risks and management options discussed at the time of diagnosis of breast cancer.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAdult-
dc.subject.meshAge Factors-
dc.subject.meshBreast Neoplasms-
dc.subject.meshChoice Behavior-
dc.subject.meshFemale-
dc.subject.meshGenes, BRCA1-
dc.subject.meshGenes, BRCA2-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenetic Screening-
dc.subject.meshHumans-
dc.subject.meshMass Screening-
dc.subject.meshMastectomy-
dc.subject.meshMiddle Aged-
dc.subject.meshRisk Factors-
dc.titleSurgical decisions made by 158 women with hereditary breast cancer aged <50 years.en
dc.typeArticleen
dc.contributor.departmentAcademic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Hathersage Road, Manchester, UK. gareth.evans@cmmc.nhs.uken
dc.identifier.journalEuropean Journal of Surgical Oncologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.