Rotavirus as a significant cause of prolonged diarrhoeal illness and morbidity following allogeneic bone marrow transplantation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/75823
Title:
Rotavirus as a significant cause of prolonged diarrhoeal illness and morbidity following allogeneic bone marrow transplantation.
Authors:
Liakopoulou, Effie F; Mutton, K J; Carrington, D; Robinson, Stephen P; Steward, C G; Goulden, N J; Cornish, J M; Marks, David I
Abstract:
Infective diarrhoea is common among allogeneic stem cell transplant (SCT) recipients, frequently caused by viruses and may be difficult to differentiate from acute graft-versus-host disease (GVHD). Viral pathogens may directly or indirectly impact upon transplant-related mortality. Rotavirus is one of the most common causes of diarrhoea worldwide, but one of the least studied causes of diarrhoea post SCT. In this retrospective study we describe 21 cases of confirmed rotavirus infection in allogeneic SCT recipients. Most of these cases may occur in clusters during the winter and spring period. Symptoms of rotaviral infection were diarrhoea (95%), vomiting (62%), abdominal pain (38%), weight loss and loss of appetite in 38 and 29% of the cases, respectively. Possible extraintestinal manifestations of rotavirus infection were observed. The duration of the symptoms in this series ranged from 4 days to 4 months with median of 15 days. Patients with rotavirus infection were invariably lymphopenic and/or on immunosuppression for GVHD. Of the patients diagnosed with rotavirus, 86% required hospitalisation. In 57% of the cases, other viral pathogens were isolated near to the rotavirus infection period. Rotavirus infection is an important cause of prolonged diarrhoea post SCT, causing significant morbidity and frequently requiring hospitalisation.
Affiliation:
Bone Marrow Transplant Unit, Christie Hospital NHS Trust, Manchester, UK. Effie.Liakopoulou@christie-tr.nwest.nhs.uk
Citation:
Rotavirus as a significant cause of prolonged diarrhoeal illness and morbidity following allogeneic bone marrow transplantation. 2005, 36 (8):691-4 Bone Marrow Transplant.
Journal:
Bone Marrow Transplantation
Issue Date:
Oct-2005
URI:
http://hdl.handle.net/10541/75823
DOI:
10.1038/sj.bmt.1705127
PubMed ID:
16113671
Type:
Article
Language:
en
ISSN:
0268-3369
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLiakopoulou, Effie F-
dc.contributor.authorMutton, K J-
dc.contributor.authorCarrington, D-
dc.contributor.authorRobinson, Stephen P-
dc.contributor.authorSteward, C G-
dc.contributor.authorGoulden, N J-
dc.contributor.authorCornish, J M-
dc.contributor.authorMarks, David I-
dc.date.accessioned2009-07-29T12:00:15Z-
dc.date.available2009-07-29T12:00:15Z-
dc.date.issued2005-10-
dc.identifier.citationRotavirus as a significant cause of prolonged diarrhoeal illness and morbidity following allogeneic bone marrow transplantation. 2005, 36 (8):691-4 Bone Marrow Transplant.en
dc.identifier.issn0268-3369-
dc.identifier.pmid16113671-
dc.identifier.doi10.1038/sj.bmt.1705127-
dc.identifier.urihttp://hdl.handle.net/10541/75823-
dc.description.abstractInfective diarrhoea is common among allogeneic stem cell transplant (SCT) recipients, frequently caused by viruses and may be difficult to differentiate from acute graft-versus-host disease (GVHD). Viral pathogens may directly or indirectly impact upon transplant-related mortality. Rotavirus is one of the most common causes of diarrhoea worldwide, but one of the least studied causes of diarrhoea post SCT. In this retrospective study we describe 21 cases of confirmed rotavirus infection in allogeneic SCT recipients. Most of these cases may occur in clusters during the winter and spring period. Symptoms of rotaviral infection were diarrhoea (95%), vomiting (62%), abdominal pain (38%), weight loss and loss of appetite in 38 and 29% of the cases, respectively. Possible extraintestinal manifestations of rotavirus infection were observed. The duration of the symptoms in this series ranged from 4 days to 4 months with median of 15 days. Patients with rotavirus infection were invariably lymphopenic and/or on immunosuppression for GVHD. Of the patients diagnosed with rotavirus, 86% required hospitalisation. In 57% of the cases, other viral pathogens were isolated near to the rotavirus infection period. Rotavirus infection is an important cause of prolonged diarrhoea post SCT, causing significant morbidity and frequently requiring hospitalisation.en
dc.language.isoenen
dc.subjectLeukaemiaen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshBone Marrow Transplantation-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshDiarrhea-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshLeukemia-
dc.subject.meshLymphocyte Depletion-
dc.subject.meshMorbidity-
dc.subject.meshRotavirus-
dc.subject.meshRotavirus Infections-
dc.subject.meshT-Lymphocytes-
dc.subject.meshTransplantation, Homologous-
dc.titleRotavirus as a significant cause of prolonged diarrhoeal illness and morbidity following allogeneic bone marrow transplantation.en
dc.typeArticleen
dc.contributor.departmentBone Marrow Transplant Unit, Christie Hospital NHS Trust, Manchester, UK. Effie.Liakopoulou@christie-tr.nwest.nhs.uken
dc.identifier.journalBone Marrow Transplantationen

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