2.50
Hdl Handle:
http://hdl.handle.net/10541/75663
Title:
Synthesis and evaluation of double bond substituted combretastatins.
Authors:
Hadfield, John A; Gaukroger, Keira; Hirst, Nicholas; Weston, Anna P; Lawrence, Nicholas J; McGown, Alan T
Abstract:
A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.
Affiliation:
Centre for Molecular Drug Design, Cockcroft Building, University of Salford, Manchester M5 4WT, UK. j.a.hadfield@salford.ac.uk
Citation:
Synthesis and evaluation of double bond substituted combretastatins. 2005, 40 (6):529-41 Eur J Med Chem
Journal:
European Journal of Medicinal Chemistry
Issue Date:
Jun-2005
URI:
http://hdl.handle.net/10541/75663
DOI:
10.1016/j.ejmech.2004.12.008
PubMed ID:
15922837
Type:
Article
Language:
en
ISSN:
0223-5234
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHadfield, John A-
dc.contributor.authorGaukroger, Keira-
dc.contributor.authorHirst, Nicholas-
dc.contributor.authorWeston, Anna P-
dc.contributor.authorLawrence, Nicholas J-
dc.contributor.authorMcGown, Alan T-
dc.date.accessioned2009-07-24T15:38:50Z-
dc.date.available2009-07-24T15:38:50Z-
dc.date.issued2005-06-
dc.identifier.citationSynthesis and evaluation of double bond substituted combretastatins. 2005, 40 (6):529-41 Eur J Med Chemen
dc.identifier.issn0223-5234-
dc.identifier.pmid15922837-
dc.identifier.doi10.1016/j.ejmech.2004.12.008-
dc.identifier.urihttp://hdl.handle.net/10541/75663-
dc.description.abstractA series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.en
dc.language.isoenen
dc.subject.meshAmides-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshBibenzyls-
dc.subject.meshCell Cycle-
dc.subject.meshCell Survival-
dc.subject.meshEpoxy Compounds-
dc.subject.meshFormazans-
dc.subject.meshHumans-
dc.subject.meshInhibitory Concentration 50-
dc.subject.meshK562 Cells-
dc.subject.meshMagnetic Resonance Spectroscopy-
dc.subject.meshMolecular Structure-
dc.subject.meshSpectrophotometry, Ultraviolet-
dc.subject.meshStilbenes-
dc.subject.meshTetrazolium Salts-
dc.subject.meshTubulin-
dc.subject.meshTubulin Modulators-
dc.titleSynthesis and evaluation of double bond substituted combretastatins.en
dc.typeArticleen
dc.contributor.departmentCentre for Molecular Drug Design, Cockcroft Building, University of Salford, Manchester M5 4WT, UK. j.a.hadfield@salford.ac.uken
dc.identifier.journalEuropean Journal of Medicinal Chemistryen

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