Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract.

2.50
Hdl Handle:
http://hdl.handle.net/10541/75634
Title:
Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract.
Authors:
Dempsey, Clare E; Dive, Caroline ( 0000-0002-1726-8850 ) ; Fletcher, Daniel J; Barnes, Frances A; Lobo, Alan; Bingle, Colin D; Whyte, Moira K B; Renshaw, Stephen A
Abstract:
Reduced expression of pro-apoptotic Bcl-2 family proteins has been described in many gastrointestinal cancers, and may play a role in tumourigenesis. The human homologue of the pro-apoptotic Bcl-2 protein, Bfk, is predominantly expressed in tissues of the gastrointestinal tract. In colon, four alternatively spliced isoforms were identified; of which two are pro-apoptotic when overexpressed. In the transition from normal tissue to tumour, pro-apoptotic Bfk isoform expression is substantially reduced in up to 80% of tumours isolated from the human gastrointestinal tract (8/10 colonic tumours and 26/37 of all gastrointestinal tumours) compared to 3/117 tumours from outside the gastrointestinal tract. These data suggest that pro-apoptotic isoforms of Bfk may help to protect against the development of human gastrointestinal malignancy.
Affiliation:
Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, United Kingdom.
Citation:
Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. 2005, 579 (17):3646-50 FEBS Lett.
Journal:
FEBS Letters
Issue Date:
4-Jul-2005
URI:
http://hdl.handle.net/10541/75634
DOI:
10.1016/j.febslet.2005.05.050
PubMed ID:
15961081
Type:
Article
Language:
en
ISSN:
0014-5793
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDempsey, Clare E-
dc.contributor.authorDive, Caroline-
dc.contributor.authorFletcher, Daniel J-
dc.contributor.authorBarnes, Frances A-
dc.contributor.authorLobo, Alan-
dc.contributor.authorBingle, Colin D-
dc.contributor.authorWhyte, Moira K B-
dc.contributor.authorRenshaw, Stephen A-
dc.date.accessioned2009-07-24T15:18:59Z-
dc.date.available2009-07-24T15:18:59Z-
dc.date.issued2005-07-04-
dc.identifier.citationExpression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. 2005, 579 (17):3646-50 FEBS Lett.en
dc.identifier.issn0014-5793-
dc.identifier.pmid15961081-
dc.identifier.doi10.1016/j.febslet.2005.05.050-
dc.identifier.urihttp://hdl.handle.net/10541/75634-
dc.description.abstractReduced expression of pro-apoptotic Bcl-2 family proteins has been described in many gastrointestinal cancers, and may play a role in tumourigenesis. The human homologue of the pro-apoptotic Bcl-2 protein, Bfk, is predominantly expressed in tissues of the gastrointestinal tract. In colon, four alternatively spliced isoforms were identified; of which two are pro-apoptotic when overexpressed. In the transition from normal tissue to tumour, pro-apoptotic Bfk isoform expression is substantially reduced in up to 80% of tumours isolated from the human gastrointestinal tract (8/10 colonic tumours and 26/37 of all gastrointestinal tumours) compared to 3/117 tumours from outside the gastrointestinal tract. These data suggest that pro-apoptotic isoforms of Bfk may help to protect against the development of human gastrointestinal malignancy.en
dc.language.isoenen
dc.subjectGastrointestinal Canceren
dc.subject.meshAlternative Splicing-
dc.subject.meshAmino Acid Sequence-
dc.subject.meshApoptosis-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshCytoplasm-
dc.subject.meshDown-Regulation-
dc.subject.meshGastrointestinal Neoplasms-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshHumans-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshProtein Isoforms-
dc.subject.meshProto-Oncogene Proteins c-bcl-2-
dc.subject.meshRNA, Messenger-
dc.titleExpression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract.en
dc.typeArticleen
dc.contributor.departmentAcademic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, United Kingdom.en
dc.identifier.journalFEBS Lettersen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.