Association of gain and loss of weight before and after menopause with risk of postmenopausal breast cancer in the Iowa women's health study.

2.50
Hdl Handle:
http://hdl.handle.net/10541/74924
Title:
Association of gain and loss of weight before and after menopause with risk of postmenopausal breast cancer in the Iowa women's health study.
Authors:
Harvie, Michelle N; Howell, Anthony ( 0000-0002-3879-5991 ) ; Vierkant, Robert A; Kumar, Nagi; Cerhan, James R; Kelemen, Linda E; Folsom, Aaron R; Sellers, Thomas A
Abstract:
Obesity and adult weight gain are well-established risk factors for postmenopausal breast cancer. Although there are a few studies demonstrating the contribution of adult weight gain to breast cancer risk, whether weight gain during a critical time period is specifically associated with risk, or whether subsequent weight loss among women who have gained weight will reduce the excess risk, is not firmly established. We investigated the association of changes in weight (loss or gain in excess of 5% of body weight) using two risk factor models: (a) age 18 to 30 years and age 30 years to menopause and (b) age 30 years to menopause and after the menopause to the baseline study in 1986 on risk of postmenopausal breast cancer in a prospective cohort of 33,660 postmenopausal women in Iowa. Over 15 years of follow-up, 1,987 cases of breast cancer occurred. Data were analyzed using proportional hazards regression models adjusted for established breast cancer risk factors. The most frequently observed pattern of body weight over time was a consistent increase; these women were observed to have the highest rates of breast cancer and served as the reference category for all comparisons. The lowest-risk groups were (a) women who maintained or lost weight from age 18 to 30 years and then lost weight from age 30 years to menopause [risk ratio (RR), 0.36; 95% confidence interval (95% CI), 0.22-0.60] and (b) women who maintained or lost weight from age 30 years to menopause and then lost weight after the menopause (RR, 0.48; 95% CI, 0.22-0.65). Women who gained weight from age 30 years to menopause but then lost weight after the menopause experienced risk reductions (RR, 0.77; 95% CI, 0.64-0.92) although perhaps slightly smaller in magnitude than women who maintained their weight in both time intervals (RR, 0.63; 95% CI, 0.55-0.73). Women who gained weight from age 18 to 30 years and then lost weight from age 30 years to menopause had comparable risk reductions (RR, 0.61; 95% CI, 0.46-0.8) with women who maintained their weight in both time intervals (RR, 0.73; 95% CI, 0.64-0.84). Women who gained weight during the period from age 30 years to menopause but who had stable weight after menopause had rates similar to the reference group. These data suggest prevention of weight gain between age 18 years and menopause or weight loss and maintenance during these years reduces risk of postmenopausal breast cancer.
Affiliation:
Univeristy Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom.
Citation:
Association of gain and loss of weight before and after menopause with risk of postmenopausal breast cancer in the Iowa women's health study. 2005, 14 (3):656-61 Cancer Epidemiol. Biomarkers Prev.
Journal:
Cancer Epidemiology, Biomarkers & Prevention
Issue Date:
Mar-2005
URI:
http://hdl.handle.net/10541/74924
DOI:
10.1158/1055-9965.EPI-04-0001
PubMed ID:
15767346
Type:
Article
Language:
en
ISSN:
1055-9965
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHarvie, Michelle N-
dc.contributor.authorHowell, Anthony-
dc.contributor.authorVierkant, Robert A-
dc.contributor.authorKumar, Nagi-
dc.contributor.authorCerhan, James R-
dc.contributor.authorKelemen, Linda E-
dc.contributor.authorFolsom, Aaron R-
dc.contributor.authorSellers, Thomas A-
dc.date.accessioned2009-07-22T10:33:39Z-
dc.date.available2009-07-22T10:33:39Z-
dc.date.issued2005-03-
dc.identifier.citationAssociation of gain and loss of weight before and after menopause with risk of postmenopausal breast cancer in the Iowa women's health study. 2005, 14 (3):656-61 Cancer Epidemiol. Biomarkers Prev.en
dc.identifier.issn1055-9965-
dc.identifier.pmid15767346-
dc.identifier.doi10.1158/1055-9965.EPI-04-0001-
dc.identifier.urihttp://hdl.handle.net/10541/74924-
dc.description.abstractObesity and adult weight gain are well-established risk factors for postmenopausal breast cancer. Although there are a few studies demonstrating the contribution of adult weight gain to breast cancer risk, whether weight gain during a critical time period is specifically associated with risk, or whether subsequent weight loss among women who have gained weight will reduce the excess risk, is not firmly established. We investigated the association of changes in weight (loss or gain in excess of 5% of body weight) using two risk factor models: (a) age 18 to 30 years and age 30 years to menopause and (b) age 30 years to menopause and after the menopause to the baseline study in 1986 on risk of postmenopausal breast cancer in a prospective cohort of 33,660 postmenopausal women in Iowa. Over 15 years of follow-up, 1,987 cases of breast cancer occurred. Data were analyzed using proportional hazards regression models adjusted for established breast cancer risk factors. The most frequently observed pattern of body weight over time was a consistent increase; these women were observed to have the highest rates of breast cancer and served as the reference category for all comparisons. The lowest-risk groups were (a) women who maintained or lost weight from age 18 to 30 years and then lost weight from age 30 years to menopause [risk ratio (RR), 0.36; 95% confidence interval (95% CI), 0.22-0.60] and (b) women who maintained or lost weight from age 30 years to menopause and then lost weight after the menopause (RR, 0.48; 95% CI, 0.22-0.65). Women who gained weight from age 30 years to menopause but then lost weight after the menopause experienced risk reductions (RR, 0.77; 95% CI, 0.64-0.92) although perhaps slightly smaller in magnitude than women who maintained their weight in both time intervals (RR, 0.63; 95% CI, 0.55-0.73). Women who gained weight from age 18 to 30 years and then lost weight from age 30 years to menopause had comparable risk reductions (RR, 0.61; 95% CI, 0.46-0.8) with women who maintained their weight in both time intervals (RR, 0.73; 95% CI, 0.64-0.84). Women who gained weight during the period from age 30 years to menopause but who had stable weight after menopause had rates similar to the reference group. These data suggest prevention of weight gain between age 18 years and menopause or weight loss and maintenance during these years reduces risk of postmenopausal breast cancer.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshObesity-
dc.subject.meshOdds Ratio-
dc.subject.meshPostmenopause-
dc.subject.meshRisk Factors-
dc.subject.meshWeight Gain-
dc.subject.meshWeight Loss-
dc.titleAssociation of gain and loss of weight before and after menopause with risk of postmenopausal breast cancer in the Iowa women's health study.en
dc.typeArticleen
dc.contributor.departmentUniveristy Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalCancer Epidemiology, Biomarkers & Preventionen

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