Pre-operative plasma levels of vascular endothelial growth factor A, C and D in patients with colorectal cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/74896
Title:
Pre-operative plasma levels of vascular endothelial growth factor A, C and D in patients with colorectal cancer.
Authors:
Duff, Sarah E; Saunders, Mark P; McCredie, V; Kumar, Shant; O'Dwyer, Sarah T; Jayson, Gordon C ( 0000-0002-8515-8944 )
Abstract:
AIMS: Vascular endothelial growth factor (VEGF)-C and VEGF-D are angiogenic and lymphangiogenic members of the VEGF family of growth factors. Increased VEGF-C or VEGF-D expression in human tumours may be associated with lymph-node metastasis and lymphatic invasion. Circulating plasma levels of VEGF-A, VEGF-C and VEGF-D were measured in patients with colorectal cancer, and assessed for their usefulness as a diagnostic tool for determining lymph-node metastasis. MATERIALS AND METHODS: One hundred and twenty patients with colorectal cancer and 50 healthy control patients were included in the study. Plasma growth-factor levels were assessed by enzyme-linked immunosorbent assays. RESULTS: No significant differences in plasma VEGF-C or VEGF-D levels were seen between patients subgrouped by clinicopathological variables. In particular, there were no differences in median plasma VEGF-C or VEGF-D level in patients with and without lymph-node involvement (VEGF-C: 11.2 U/ml [range, 4.9-51.9] vs 9.9 U/ml [4.4-93.4 U/ml]; P = 0.90; VEGF-D: 335 pg/ml [113-1102] vs 316.5 pg/ml [0-1343]; P = 0.68). CONCLUSIONS: Circulating plasma levels of VEGF-C and VEGF-D do not allow pre-operative identification of lymph-node status in patients with colorectal cancer.
Affiliation:
Department of Surgery, Christie Hospital NHS Trust, Manchester, UK. saraheduff@aol.com
Citation:
Pre-operative plasma levels of vascular endothelial growth factor A, C and D in patients with colorectal cancer. 2005, 17 (5):367-71 Clin Oncol
Journal:
Clinical Oncology
Issue Date:
Aug-2005
URI:
http://hdl.handle.net/10541/74896
PubMed ID:
16097569
Type:
Article
Language:
en
ISSN:
0936-6555
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDuff, Sarah E-
dc.contributor.authorSaunders, Mark P-
dc.contributor.authorMcCredie, V-
dc.contributor.authorKumar, Shant-
dc.contributor.authorO'Dwyer, Sarah T-
dc.contributor.authorJayson, Gordon C-
dc.date.accessioned2009-07-22T09:20:07Z-
dc.date.available2009-07-22T09:20:07Z-
dc.date.issued2005-08-
dc.identifier.citationPre-operative plasma levels of vascular endothelial growth factor A, C and D in patients with colorectal cancer. 2005, 17 (5):367-71 Clin Oncolen
dc.identifier.issn0936-6555-
dc.identifier.pmid16097569-
dc.identifier.urihttp://hdl.handle.net/10541/74896-
dc.description.abstractAIMS: Vascular endothelial growth factor (VEGF)-C and VEGF-D are angiogenic and lymphangiogenic members of the VEGF family of growth factors. Increased VEGF-C or VEGF-D expression in human tumours may be associated with lymph-node metastasis and lymphatic invasion. Circulating plasma levels of VEGF-A, VEGF-C and VEGF-D were measured in patients with colorectal cancer, and assessed for their usefulness as a diagnostic tool for determining lymph-node metastasis. MATERIALS AND METHODS: One hundred and twenty patients with colorectal cancer and 50 healthy control patients were included in the study. Plasma growth-factor levels were assessed by enzyme-linked immunosorbent assays. RESULTS: No significant differences in plasma VEGF-C or VEGF-D levels were seen between patients subgrouped by clinicopathological variables. In particular, there were no differences in median plasma VEGF-C or VEGF-D level in patients with and without lymph-node involvement (VEGF-C: 11.2 U/ml [range, 4.9-51.9] vs 9.9 U/ml [4.4-93.4 U/ml]; P = 0.90; VEGF-D: 335 pg/ml [113-1102] vs 316.5 pg/ml [0-1343]; P = 0.68). CONCLUSIONS: Circulating plasma levels of VEGF-C and VEGF-D do not allow pre-operative identification of lymph-node status in patients with colorectal cancer.en
dc.language.isoenen
dc.subjectColorectal Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCohort Studies-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshVascular Endothelial Growth Factor A-
dc.subject.meshVascular Endothelial Growth Factor C-
dc.subject.meshVascular Endothelial Growth Factor D-
dc.subject.meshVascular Endothelial Growth Factors-
dc.titlePre-operative plasma levels of vascular endothelial growth factor A, C and D in patients with colorectal cancer.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Christie Hospital NHS Trust, Manchester, UK. saraheduff@aol.comen
dc.identifier.journalClinical Oncologyen
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